Adjunct Research Professor, Research Scientist
|Degrees:||BSc, PhD (McMaster)|
|Office:||Environment Health Centre|
Ottawa, ON K1A 0L2
BSc McMaster University, 1993
Ph.D. McMaster University, 1999
The government of Canada is responsible for the evaluation of potential human health effects for all chemicals in commerce in Canada. Over 20,000 chemicals are on Health Canada’s domestic substance list, and new methods are urgently needed to rapidly and effectively evaluate their toxicity. One focus of research in my laboratory centres on the development and application of novel genomic approaches for regulatory toxicology and human health risk assessment. Within this broad theme, we are using gene expression technologies (e.g., DNA microarrays and RNA-sequencing) to study gene and non-coding expression following exposure to chemicals. These data are used to identify pathways linked to specific toxicity outcomes, with the overall goal of developing a means to apply genomics profiles in regulatory risk assessment, and identify novel biomarkers of exposure and effect. Other research in my group focuses on the impact of exposure to toxic chemicals on gametes (sperm and egg) and their potential repercussions to the next generation. This work explores the effects of chemicals on germline DNA mutation and works towards the development of improved methods to identify such toxicants.
Jackson AF, Williams A, Recio L, Waters MD, Lambert IB, Yauk CL. Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan. Toxicol Appl Pharmacol. 2014 Jan 1;274(1):63-77.
Thomas RS, Philbert MA, Auerbach SS, Wetmore BA, Devito MJ, Cote I, Rowlands JC, Whelan MP, Hays SM, Andersen ME, Meek ME, Reiter LW, Lambert JC, Clewell HJ 3rd, Stephens ML, Zhao QJ, Wesselkamper SC, Flowers L, Carney EW, Pastoor TP, Petersen DD, Yauk CL, Nong A. Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework. Toxicol Sci. 2013 Nov;136(1):4-18.
Malik AI, Rowan-Carroll A, Williams A, Lemieux CL, Long AS, Arlt VM, Phillips DH, White PA, Yauk CL. Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene. Mutagenesis. 2013 Sep;28(5):543-54.
Linschooten JO, Verhofstad N, Gutzkow K, Olsen AK, Yauk C, Oligschläger Y, Brunborg G, van Schooten FJ, Godschalk RW. Paternal lifestyle as a potential source of germline mutations transmitted to offspring. FASEB J. 2013 Jul;27(7):2873-9.
Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB. Harnessing genomics to identify environmental determinants of heritable disease. Mutat Res. 2013 Jan-Mar;752(1):6-9.
Swayne BG, Kawata A, Behan NA, Williams A, Wade MG, Macfarlane AJ, Yauk CL. Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in Balb/c mice. Mutat Res. 2012 Sep 1;737(1-2):1-7.
Bourdon JA, Williams A, Kuo B, Moffat I, White PA, Halappanavar S, Vogel U, Wallin H, Yauk CL. Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure. Toxicology. 2013 Jan 7;303:83-93.