Nicolas Rodrigue
Associate Professor, Department of Biology (Cross appointment – Biology)
| Degrees: | BA (Bishop's), BSc (McGill), MSc (École de technologie supérieure), PhD (Montreal) |
| Phone: | 613-520-2600 x 4194 |
| Email: | nicolas.rodrigue@carleton.ca |
| Office: | 4610 CTTC |
| Website: | Browse |
Research
My main area of research deals with Bayesian modeling of molecular evolution, primarily focused on protein-coding genes and the various forces (e.g., mutation, selection, drift) that have shaped extant sequences. In this line, I am also interested in Markov chain Monte Carlo methods and high-performance statistical computing. Other areas that interest me include protein structure modeling, statistical protein design, and next-generation-sequencing approaches for studying viral and microbial evolution in clinical and experimental settings.
Selected Publications
Rodrigue, N. and Lartillot, N. (2014). Site-heterogeneous mutation-selection models within the PhyloBayes-MPI package. Bioinformatics, 30:1020-1021.
Dettman, J. R., Rodrigue, N., Aaron, S. D. and Kassen, R. (2013). Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U. S. A., 110:21065-21070.
Rodrigue, N. (2013). On the statistical interpretation of site-specific variables in phylogeny-based substitution models. Genetics, 193:557-564.
Dettman, J. R., Rodrigue, N., Melnyk, A. H., Wong, A., Bailey, S. F., and Kassen, R. (2012). Evolutionary insights from whole-genome sequencing of experimentally evolved microbes. Mol. Ecol. 20:2058-2077.
Rodrigue, N., Philippe, H. and Lartillot, N. (2010). Mutation-selection models of coding sequence evolution with site-heterogeneous amino acid fitness profiles. Proc. Natl. Acad. Sci. U. S. A., 107:4629-4634.