{"id":3840,"date":"2025-06-02T15:02:02","date_gmt":"2025-06-02T19:02:02","guid":{"rendered":"https:\/\/carleton.ca\/biochem\/?post_type=cu_people&p=3840"},"modified":"2025-06-02T15:03:36","modified_gmt":"2025-06-02T19:03:36","slug":"nicolas-rodrigue","status":"publish","type":"cu_people","link":"https:\/\/carleton.ca\/biochem\/people\/nicolas-rodrigue\/","title":{"rendered":"Nicolas Rodrigue"},"content":{"rendered":"
\n

\n \n \n \n <\/h1>\n\n \n <\/header>\n\n\n\n\n\n

Research<\/h3>\n\n\n\n

My main area of research deals with Bayesian modeling of molecular evolution, primarily focused on protein-coding genes and the various forces (e.g., mutation, selection, drift) that have shaped extant sequences. In this line, I am also interested in Markov chain Monte Carlo methods and high-performance statistical computing. Other areas that interest me include protein structure modeling, statistical protein design, and next-generation-sequencing approaches for studying viral and microbial evolution in clinical and experimental settings.<\/p>\n\n\n\n

Selected Publications<\/h3>\n\n\n\n

Rodrigue, N.<\/strong> and Lartillot, N. (2017). Detecting adaptation in protein-coding genes using a site-heterogeneous mutation-selection model. Mol. Biol. Evol., 34:204-214.<\/p>\n\n\n\n

Lee, H.-J., Kishino, H., Rodrigue, N.<\/strong> and Thorne, J. L. (2016). Grouping substitution types into different relaxed molecular clocks. Phil. Trans. R. Soc. B, 371:20150141.<\/p>\n\n\n\n

Bailey, S. F., Rodrigue, N.<\/strong> and Kassen, R. (2015). Selection environment drives the degree of parallel evolution in experimentally evolved populations of Pseudomonas fluorescens. Mol. Biol. Evol., 32:1436-1448.<\/p>\n\n\n\n

Rodrigue, N.<\/strong> and Lartillot, N. (2014). Site-heterogeneous mutation-selection models within the PhyloBayes-MPI package. Bioinformatics, 30:1020-1021.<\/p>\n\n\n\n

Dettman, J. R., Rodrigue, N.<\/strong>, Aaron, S. and Kassen, R. (2013). Evolutionary genomics of epidemic and non-epidemic strains of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A., 110:21065-21070.<\/p>\n\n\n\n

Rodrigue, N.<\/strong>\u00a0(2013). On the statistical interpretation of site-specific variables in phylogeny-based substitution models.\u00a0Genetics, 193:557-564.<\/p>\n\n\n\n

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