Adjunct Research Professor, Research Scientist
|Degrees:||B.Sc., Ph.D. (McMaster)|
|Office:||Environment Health Centre|
Ottawa, ON K1A 0L2
The government of Canada is responsible for the evaluation of potential human health effects for all chemicals in commerce in Canada. With over 20,000 chemicals on Canada’s domestic substances list, new methods are urgently needed to rapidly and effectively evaluate their toxicity. One focus of research in my laboratory centres on the development and application of novel genomic approaches for regulatory toxicology and human health risk assessment. Within this broad theme, we are using gene expression technologies (e.g., RNA-sequencing) to study transcriptional changes that occur following exposure to chemicals. These data are used to identify alterations in pathways linked to specific toxicity outcomes, with the overall goal of developing methods to apply genomics profiles in regulatory risk assessment, and identify novel biomarkers of exposure and effect. Other research in my group focuses on the impact of exposure to toxic chemicals on gametes (sperm and egg) and their potential repercussions to the next generation. This work explores the effects of chemicals on germline DNA mutation rates and works towards the development of improved methods to identify such toxicants.
Farmahin R, Williams A, Kuo B, Chepelev NL, Thomas RS, Barton-Maclaren TS, Curran IH, Nong A, Wade MG, Yauk CL. Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment. Arch Toxicol. 2016 Dec 7.
Chauhan V, Kuo B, McNamee JP, Wilkins RC, Yauk CL. Transcriptional benchmark dose modeling: Exploring how advances in chemical risk assessment may be applied to the radiation field. Environ Mol Mutagen. 2016 Oct;57(8):589-604. doi: 10.1002/em.22043.
Meier MJ, O’Brien JM, Beal MA, Allan B, Yauk CL, Marchetti F. In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice. Environ Health Perspect. 2017 Jan;125(1):82-88. doi: 10.1289/EHP211.
O’Brien JM, Beal MA, Yauk CL, Marchetti F. Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia. Toxicol Sci. 2016 Aug;152(2):363-71. doi: 10.1093/toxsci/kfw088.
Chepelev NL, Long AS, Bowers WJ, Gagné R, Williams A, Kuo B, Phillips DH, Arlt VM, White PA, Yauk CL. Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene. Environ Mol Mutagen. 2016 Jun;57(5):350-63. doi: 10.1002/em.22020.
Li HH, Hyduke DR, Chen R, Heard P, Yauk CL, Aubrecht J, Fornace AJ Jr. Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells. Environ Mol Mutagen. 2015 Jul;56(6):505-19. doi: 10.1002/em.21941.
Beal MA, Gagné R, Williams A, Marchetti F, Yauk CL. Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing.BMC Genomics. 2015 Oct 19;16:812. doi: 10.1186/s12864-015-2004-4.
Webster AF, Zumbo P, Fostel J, Gandara J, Hester SD, Recio L, Williams A, Wood CE, Yauk CL, Mason CE. Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded Tissues. Toxicol Sci. 2015 Dec;148(2):460-72. doi: 10.1093/toxsci/kfv195.
Jackson AF, Williams A, Recio L, Waters MD, Lambert IB, Yauk CL. Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan. Toxicol Appl Pharmacol. 2014 Jan 1;274(1):63-77.
Thomas RS, Philbert MA, Auerbach SS, Wetmore BA, Devito MJ, Cote I, Rowlands JC, Whelan MP, Hays SM, Andersen ME, Meek ME, Reiter LW, Lambert JC, Clewell HJ 3rd, Stephens ML, Zhao QJ, Wesselkamper SC, Flowers L, Carney EW, Pastoor TP, Petersen DD, Yauk CL, Nong A. Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework. Toxicol Sci. 2013 Nov;136(1):4-18.
Linschooten JO, Verhofstad N, Gutzkow K, Olsen AK, Yauk C, Oligschläger Y, Brunborg G, van Schooten FJ, Godschalk RW. Paternal lifestyle as a potential source of germline mutations transmitted to offspring. FASEB J. 2013 Jul;27(7):2873-9.
Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB. Harnessing genomics to identify environmental determinants of heritable disease. Mutat Res. 2013 Jan-Mar;752(1):6-9.