Adjunct Research Professor, Research Scientist
|Degrees:||B.Sc., Ph.D. (McMaster)|
|Office:||Environment Health Centre|
Ottawa, ON K1A 0L2
The government of Canada is responsible for the evaluation of potential human health effects for all chemicals in commerce in Canada. With over 20,000 chemicals on Canada’s domestic substances list, new methods are urgently needed to rapidly and effectively evaluate their toxicity. One focus of research in my laboratory centres on the development and application of novel genomic approaches for regulatory toxicology and human health risk assessment. Within this broad theme, we are using gene expression technologies (e.g., RNA-sequencing) to study transcriptional changes that occur following exposure to chemicals. These data are used to identify alterations in pathways linked to specific toxicity outcomes, with the overall goal of developing methods to apply genomics profiles in regulatory risk assessment, and identify novel biomarkers of exposure and effect. Other research in my group focuses on the impact of exposure to toxic chemicals on gametes (sperm and egg) and their potential repercussions to the next generation. This work explores the effects of chemicals on germline DNA mutation rates and works towards the development of improved methods to identify such toxicants.
Farmahin R, Gannon AM, Gagné R, Rowan-Carroll A, Kuo B, Williams A, Curran I, Yauk CL. (2018) Hepatic transcriptional dose-response analysis of male and female Fischer rats exposed to hexabromocyclododecane. Food Chem Toxicol. 2018 Dec 27. pii: S0278-6915(18)30905-0. doi: 10.1016/j.fct.2018.12.032.
Philips, J., Svoboda, D., Tandon, A., Patel, S., Sedykh, A., Mav, D., Kuo, B., Yauk, C., Yang, L., Thomas, R.S., Gift, J., Davis, A., Olysyzk, L., Parham, F., Saddler, T., Shah, R., Auerbach, S.S. (2018) BMDExpress 2: Enhanced transcriptomic dose-response analysis workflow. Bioinformatics. 2018 Oct 17.
Chauhan, V., Said, Z., Daka, J., Sadi, B., Bijlani, D., Marchetti, F., Beaton, D., Gaw, A., Li, C., Burtt, J., Leblanc, J., Desoriers, M., Sutart, M., Brossard, M., Vuong, N., Wilkins, R., Qutob, S., McNamee, J., Wang, Y., Yauk, C. (2018) Is there a Role for the Adverse Outcome Pathway Framework to Support Radiation Protection? International Journal of Radiation Biology. Feb;95(2):225-232.
Maurice, C., O’Brien, J.M., Yauk, C.L., Marchetti, F. (2018) Integration of sperm DNA damage assessment into OECD test guidelines for genotoxicity testing using the MutaMouse model. Toxicology and Applied Pharmacology. Oct 15;357:10-18. doi: 10.1016/j.taap.2018.08.021.
Webster, R.J., Williams, A., Marchetti, F., Yauk, C.L. (2018) Discovering human germ cell mutagens with whole genome sequencing: insights from power calculations reveal the importance of controlling for between family variability. Mutation Research. 831:24-32. doi: 10.1016/j.mrgentox.2018.04.004.
Chepelev, N., Gagné, R., Maynor, T., Kuo, B., Hobbs, C.A., Recio, L., Yauk, C.L., (2018) Transcriptional profiling of male CD-1 mouse lungs and Harderian glands supports the involvement of calcium signaling in acrylamide induced tumors. Regulatory Toxicology and Pharmacology. Jun;95:75-90. doi: 10.1016/j.yrtph.2018.02.005
Buick, J.K., Williams, A., Kuo, B., Wills, J.W., Swartz, C.D., Recio, L., Li, H.H., Fornace, A.J., Aubrecht, J., Yauk, C.L. (2017) Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells. Mutat Res. 2017 Dec;806:51-62. doi: 10.1016/j.mrfmmm.2017.09.002.
Li, H., Chen, R., Hyduke, D., Williams, A., Frostschl, R., Ellinger-Ziegelbauer, H., O’Lone, R., Yauk, C., Aubrecht, J., Fornace, A.J. (2017) Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs. Proceedings of the National Academy of Sciences, USA. 114(51):E10881-E10889. doi: 10.1073/pnas.1714109114.
Beal, M.A., Yauk, C.L., Marchetti, F. (2017) From Sperm to Offspring: Assessing the Heritable Genetic Consequences of Paternal Smoking and Potential Public Health Impacts. Mutation Research Reviews. 773:26-50.
Halappanavar, S., Vogel, U., Wallin, H., Yauk, C.L. (2017) Promise and peril in nanomedicine: the challenges and needs for integrated systems biology approaches to define health risk. WIREs Nanomedicine & Nanobiotechnology. Mar 15. doi: 10.1002/wnan.1465.
Chauhan, V., Kuo, B., McNamee, J., Wilkins, R.C., Yauk, C.L. (2016) Transcriptional Benchmark Dose modeling: exploring how advances in chemical risk assessment may be applied to the radiation field. Environ. Mol. Mutagen. 57(8):589-604.
Farmahin, R., Williams, A., Kuo, B., Chepelev, N.L., Thomas, R.S., Barton-Maclaren, T.S., Curran, I.H., Nong, A., Wade, M.G., Yauk, C.L. (2016) Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment. Archives Tox. May;91(5):2045-2065.
O’Brien, J.M., Beal, M.A., Yauk, C.L. (2016) Marchetti, F. Next generation sequencing of benzo(a)pyrene-induced lacZ mutants identify a germ cell-specific mutation spectrum. Scientific Reports. 2016 Nov 10;6:36743. doi: 10.1038/srep36743.
Chauhan, V., Kuo, B., McNamee, J., Wilkins, R.C., Yauk, C.L. Transcriptional Benchmark Dose modeling: exploring how advances in chemical risk assessment may be applied to the radiation field. Environ. Mol. Mutagen. 57(8):589-604.