Carole Yauk
Adjunct Research Professor, Professor in the Dept. of Biology, uOttawa
| Degrees: | B.Sc., Ph.D. (McMaster) |
| Phone: | 613-941-7376 |
| Email: | Carole.Yauk@uottawa.ca |
| Office: | Room 269 Gendron Dept of Biology, uOtttawa 30 Marie Curie Private Ottawa, ON, K1N 6N5 |
| Website: | Check Out My Website |
Current Research
The government of Canada is responsible for the evaluation of potential human health effects for all chemicals in commerce in Canada. With over 20,000 chemicals on Canada’s domestic substances list, new methods are urgently needed to rapidly and effectively evaluate their toxicity. One focus of research in my laboratory centres on the development and application of novel genomic approaches for regulatory toxicology and human health risk assessment. Within this broad theme, we are using gene expression technologies (e.g., RNA-sequencing) to study transcriptional changes that occur following exposure to chemicals. These data are used to identify alterations in pathways linked to specific toxicity outcomes, with the overall goal of developing methods to apply genomics profiles in regulatory risk assessment, and identify novel biomarkers of exposure and effect. Other research in my group focuses on the impact of exposure to toxic chemicals on gametes (sperm and egg) and their potential repercussions to the next generation. This work explores the effects of chemicals on germline DNA mutation rates and works towards the development of improved methods to identify such toxicants.
Selected Publications
Matteo* G, Leingartner K, Rowan-Carroll A, Meier M, Williams A, Beal MA, Gagné M, Farmahin R, Wickramasuriya S, Reardon AJF, Barton-Maclaren T, Corton C, Yauk CL, Atlas E. (2023) In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals. Toxicological Sciences (in press).
Johnson KJ, Auerbach S, Stevens T, Barton-Maclaren TX, Costa E, Currie RA, Wilk DD, Rager JE, Reardon AJF, Wehmas L, Williams A, O’Brien J, Yauk C, LaRocca JL, Pettit S (2022) A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm. Toxicological Sciences, Volume 190, Issue 2, December 2022, Pages 127–132, https://doi.org/10.1093/toxsci/kfac097
Buick JK, Rowan-Carroll A, Gagné R, Williams A, Chen R, Li H, Fornace AJJ, Chao, C, Engelward BP, Frötschl R, Ellinger-Ziegelbauer H, Pettit SD, Aubrecht J, Yauk CL (2022) Integrated Genotoxicity Testing of Three Anti-Infective Drugs using the TGx-DDI Transcriptomic Biomarker and High-Throughput CometChip® Assay in TK6 cells. Frontiers in Toxicology, Volume 4, online. https://doi.org/10.3389/ftox.2022.991590
Kozbenko* T., Adam N., Lai V., Sandhu S., Kuan J., Flores D., Appleby M., Parker H., Hocking R., Tsaioun K., Yauk C., Wilkins R., Chauhan V. (2022) Deploying elements of scoping review methods for Adverse Outcome Pathway development: A space travel case example, International Journal of Radiation Biology, Volume 22, Issue 1-12 (August 2022) Open Access, doi: 10.1080/09553002.2022.2110306
LeBlanc D.P.M., Meier M., Lo F.Y., Schmidt E., Valentine C., Williams A., Salk J.J., Yauk C.L., Marchetti F. (2022) Duplex Sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene- induced in vivo mutations, BMC Genomics, Volume 23, Issue 1, 542 (July 2022), doi: 10.1186/s12864-022-08752-w
Corton J.C., Liu J., Williams A., Cho* E., Yauk C.L. (2022) A Gene Expression Biomarker Identifies Inhibitors of Two Classes of Epigenome Effectors in a Human Microarray Compendium, Chemico-Biological Interactions (June 2022) Jun 28;110032. doi: 10.1016/j.cbi.2022.110032.
Huliganga E., Marchetti F., O’Brien J.M., Chauhan V., Yauk C., (2022) A case study on integrating a new key event into an existing adverse outcome pathway on oxidative DNA damage: challenges and approaches in a data-rich area, Frontiers in Toxicology Apr 28;4:827328. doi: 10.3389/ftox.2022.827328. eCollection 2022.
Cho E, Allemang A, Audebert M, Chauhan V, Dertinger S, Hendriks G, Luijten M, Marchetti M, Minocherhomji S, Pfuhler S, Roberts DJ, Trenz K, Yauk CL, (2022) AOP report: Development of an Adverse Outcome Pathway for Oxidative DNA Damage Leading to Mutations and Chromosomal Aberrations, Environmental and Molecular Mutagenesis. Mar;63(3):118-134. doi: 10.1002/em.22479. Epub 2022 May 3. PMID: 35315142. Editor’s Choice – featured on the front cover of the journal.
Kuo B., Beal M.A., Wills J.W., White P.A., Marchetti F., Nong A., Barton-Maclaren T.S., Houck K., Yauk C.L. (2022) Comprehensive interpretation of in vitro micronucleus test results for 292 chemicals: from hazard identification to risk assessment application. Archives of Toxicology. Accepted Feb 2022. PMID: 35445829. doi: 10.1007/s00204-022-03286-2.
Reardon, A.J.F., Rowan-Carroll, A., Ferguson, S.S., Leingartner, K., Gagne, R., Kuo, B., Williams, A., Lorusso, L., Bourdon-Lacombe, J.A., Carrier, R., Moffat, I., Yauk, C.L., Atlas E.* (2021) Potency ranking of per- and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids. Toxicological Sciences. 184(1); 154-169. Doi: 10.1093/toxsci/kfab102.
- Buick, J.K., Williams, A., Meier, M.J., Swartz, C.D., Recio, L., Gagné, R., Ferguson, S.S., Engelward, B.P., Yauk, C.L. (2021) A modern genotoxicity testing paradigm: Integration of the high-throughput CometChip® and the TGx-DDI transcriptomic biomarker in human HepaRG™ cell cultures. Frontiers in Public Health. Aug; 9: 1114. Doi: 10.3389/fpubh.2021.694834
- Rowan-Carroll, A., Reardon, A., Leingartner, K., Gagné, R., Williams, A., Meier, M.J., Kuo, B., Bourdon-Lacombe, J., Moffat, I., Carrier, R., Nong, A., Lorusso, L., Ferguson, S.S., Atlas, E., Yauk, C. (2021) High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and poly-fluoroalkyl substances (PFAS) as a platform for relative potency characterization. Toxicological Sciences. May 27;181(2):199-214. doiI: 10.1093/toxsci/kfab039 WINNER BEST PAPER OF THE YEAR.
- Cho, E., Rowan-Carroll, A., Williams, A., Corton, J.C., Li, H., Fornace Jr., A., Hobbs, C., Yauk, C.L. (2021) Development and Validation of the TGx-HDACi Transcriptomic Biomarker to Detect Histone Deacetylase Inhibitors in Human TK6 Cells. Archives of Toxicology. May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26. PMID: 33770205.
- Beal, M.A., Meier, M.J., LeBlanc, D.P., Maurice, C., O’Brien, J.M., Yauk, C.L., Marchetti, F. (2021) Chemically induced mutations in a MutaMouse reporter gene inform mechanisms underlying human cancer mutational signatures. Communications Biology. 3(1):438. doi: 10.1038/s42003-020-01174-y.