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DTSTART:20141003T193000Z
DTEND:20141003T203000Z
SUMMARY:Dr. Luc Sabourin
DESCRIPTION:The Ste20-like kinase: A critical signaling hub regulating cell invasion and tumor progression



Dr. Luc Sabourin
Senior Scientist, Cancer Therapeutics, OHRI
Associate Professor, Cellular and Molecular Medicine
University of Ottawa



Host: Golshani lab



Abstract:  Cell migration and invasion are crucial for many biological processes including morphogenesis, wound repair and cancer progression. Cell motility is tightly regulated by extracellular matrix signaling that ultimately controls cytosolic remodeling and cell movement. We have shown that the Ste20-like kinase SLK is required for cell motility downstream of the focal adhesion kinase complex. In addition to haptotaxis, SLK is necessary for HER2-driven chemotaxis and invasion. SLK regulates cell migration through the phosphorylation of paxillin, an adhesion adapter required for focal adhesion breakdown and turnover. Supporting a role for SLK in cell cycle progression, deletion of SLK in murine mammary glands markedly impairs tumorigenesis and TGF beta-induced tumor cell invasion. Overall, our studies show that SLK is critical for cell invasion and breast cancer progression, making it an attractive new target for breast cancer therapy.



cell migration - cell cycle regulation - cancer - Ste20-like kinase
LOCATION:4440Q Carleton Technology and Training Centre, Carleton University, 1125 Colonel By Dr, Ottawa, ON K1S 5B6
URL:
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