{"id":8114,"date":"2019-09-18T14:14:32","date_gmt":"2019-09-18T18:14:32","guid":{"rendered":"https:\/\/carleton.ca\/biology\/?post_type=cu-people&p=8114"},"modified":"2020-03-04T15:56:27","modified_gmt":"2020-03-04T20:56:27","slug":"sue-twine","status":"publish","type":"cu-people","link":"https:\/\/carleton.ca\/biology\/people\/sue-twine\/","title":{"rendered":"Sue Twine"},"content":{"rendered":"

Current Research<\/h2>\n

Sue currently leads Mass Spectrometry and NMR research facilities within the National Research Council\u2019s Human Health Therapeutics Research Centre, which broadly support the development of vaccines and protein based biologics. Her research focuses upon the application of mass spectrometry and allied approaches to improve understanding of the interaction of bacterial pathogens with human hosts. This includes deciphering bacterial post translational modifications and their role in host colonization (bacterial glycobiology), and the study of the host immune response to disease (immunoproteomics).<\/p>\n

Sue is also involved in the development of student and postdoctoral training programs across the National Research Council. Prospective undergraduate and graduate students are welcome to contact Sue to learn more about opportunities within her research group.<\/p>\n

Selected Publications<\/h2>\n

Complete publication list here: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=twine_s<\/a><\/p>\n

Fulton KM, Baltat I, Twine SM<\/strong>. Immunoproteomics Methods and Techniques. Methods Mol Biol. 2019;2024:25-58. doi: 10.1007\/978-1-4939-9597-4_2. PubMed PMID:31364041.<\/p>\n

Chen R, Fauteux F, Foote S, Stupak J, Tremblay TL, Gurnani K, Fulton KM, Weeratna RD, Twine SM<\/strong>, Li J. Chemical Derivatization Strategy for Extending the\u00a0Identification of MHC Class I Immunopeptides. Anal Chem. 2018 Oct\u00a02;90(19):11409-11416. doi: 10.1021\/acs.analchem.8b02420. Epub 2018 Sep 19. PubMed PMID: 30192525.<\/p>\n

Fulton KM, Li J, Tomas JM, Smith JC, Twine SM<\/strong>. Characterizing bacterial\u00a0glycoproteins with LC-MS. Expert Rev Proteomics. 2018 Mar;15(3):203-216. doi:10.1080\/14789450.2018.1435276. Epub 2018 Feb 9. Review. PubMed PMID: 29400572.<\/p>\n

Fulton KM, Mendoza-Barber\u00e1 E, Twine SM<\/strong>, Tom\u00e1s JM, Merino S. Polar Glycosylated and Lateral Non-Glycosylated Flagella from Aeromonas hydrophila Strain AH-1\u00a0(Serotype O11). Int J Mol Sci. 2015 Nov 27;16(12):28255-69. doi:10.3390\/ijms161226097. PubMed PMID: 26633358; PubMed Central PMCID: PMC4691044.<\/p>\n

M\u00e9nard R, Schoenhofen IC, Tao L, Aubry A, Bouchard P, Reid CW, Lachance P, Twine SM<\/strong>, Fulton KM, Cui Q, Hogues H, Purisima EO, Sulea T, Logan SM.\u00a0Small-molecule inhibitors of the pseudaminic acid biosynthetic pathway: targeting\u00a0motility as a key bacterial virulence factor. Antimicrob Agents Chemother. 2014\u00a0Dec;58(12):7430-40. doi: 10.1128\/AAC.03858-14. Epub 2014 Sep 29. PubMed PMID:25267679; PubMed Central PMCID: PMC4249573.<\/p>\n

Lindgren M, Tancred L, Golovliov I, Conlan W, Twine SM<\/strong>, Sj\u00f6stedt A.\u00a0Identification of mechanisms for attenuation of the FSC043 mutant of Francisella\u00a0tularensis SCHU S4. Infect Immun. 2014 Sep;82(9):3622-35. doi:10.1128\/IAI.01406-13. Epub 2014 Jun 16. PubMed PMID: 24935978; PubMed Central\u00a0PMCID: PMC4187832.<\/p>\n

Strong PC, Fulton KM, Aubry A, Foote S, Twine SM<\/strong>, Logan SM. Identification and\u00a0characterization of glycoproteins on the spore surface of Clostridium difficile.\u00a0J Bacteriol. 2014 Jul;196(14):2627-37. doi: 10.1128\/JB.01469-14. Epub 2014 May 9.\u00a0PubMed PMID: 24816601; PubMed Central PMCID: PMC4097583.<\/p>\n

Wilhelms M, Fulton KM, Twine SM<\/strong>, Tom\u00e1s JM, Merino S. Differential\u00a0glycosylation of polar and lateral flagellins in Aeromonas hydrophila AH-3. J\u00a0Biol Chem. 2012 Aug 10;287(33):27851-62. doi: 10.1074\/jbc.M112.376525. Epub 2012\u00a0Jun 25. PubMed PMID: 22733809; PubMed Central PMCID: PMC3431630<\/p>\n

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