{"id":3745,"date":"2014-11-03T11:09:59","date_gmt":"2014-11-03T16:09:59","guid":{"rendered":"http:\/\/carleton.ca\/biology\/?post_type=cu_event&#038;p=3745"},"modified":"2026-02-23T15:51:58","modified_gmt":"2026-02-23T20:51:58","slug":"dr-marc-ekker","status":"publish","type":"cu_event","link":"https:\/\/carleton.ca\/biology\/event\/dr-marc-ekker\/","title":{"rendered":"Dr. Marc Ekker"},"content":{"rendered":"<header class=\"mb-6 cu-pageheader cu-component-updated md:mb-12\">\n    <h1 class=\"cu-prose-first-last font-semibold !mt-2 mb-4 md:mb-6 text-3xl md:text-4xl lg:text-5xl lg:leading-[3.5rem] relative after:absolute after:h-px after:bottom-0 pb-5 after:w-10 after:bg-cu-red after:left-px\">\n        \n    <\/h1>\n    \n        <\/header>\n\n    \n    \n    \n    \n    <div class=\"cu-buttongroup cu-component-updated flex flex-wrap md:flex-1 gap-3 md:gap-5 justify-start\">\n                                                                        <\/div>\n    \n<p><strong>Enhancer-based analysis of Dlx function in the vertebrate forebrain<\/strong><\/p>\n\n\n\n<p>Marc Ekker, Professor of Biology, University of Ottawa<br>\nVertebrate <em>Dlx<\/em> genes encode homeodomain transcription factors involved in several aspects of embryonic development. In the developing forebrain, the mouse <em>Dlx<\/em> genes play crucial role in the migration and differentiation of GABAergic interneuron precursors. The Ekker laboratory has extensively studied <em>cis<\/em>-acting regulatory enhancers responsible for <em>Dlx<\/em> expression in the forebrain of mice and zebrafish. We have recently produced mice with targeted deletions of the <em>Dlx<\/em> forebrain enhancers. Characterization of the phenotype of these mice will be presented. In parallel to this work, we have used the <em>Dlx<\/em> forebrain enhancers to drive the CRE recombinase in lineage tracing studies carried out in zebrafish. Results in juvenile but also in adult zebrafish will be presented with an examination of the potential implications for adult neurogenesis and the regeneration of GABAergic neurons after injury.<\/p>\n\n\n\n<p>&nbsp;<\/p>\n","protected":false},"author":2,"featured_media":0,"template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"cu_event_type":[],"cu_event_audience":[],"class_list":["post-3745","cu_event","type-cu_event","status-publish","hentry"],"acf":{"cu_event_start_date":"2014-12-05T15:30:00","cu_event_end_date":"2014-12-05T16:30:00","cu_event_location_type":"in-person","cu_event_meeting_address_type":"on-campus","cu_building":"TT","cu_event_meeting_room":"4440Q","cu_event_meeting_address_full":null,"cu_event_virtual_type":"tbd","cu_event_virtual_meeting_link":"","cu_post_thumbnail":"null","cu_event_cost":"","cu_event_registration":"","cu_event_secondary_button":"","cu_event_contact_name":"Andrew Simons","cu_event_email":"andrew.simons@carleton.ca","cu_event_phone":""},"_links":{"self":[{"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/cu_event\/3745","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/cu_event"}],"about":[{"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/types\/cu_event"}],"author":[{"embeddable":true,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/users\/2"}],"version-history":[{"count":0,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/cu_event\/3745\/revisions"}],"wp:attachment":[{"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/media?parent=3745"}],"wp:term":[{"taxonomy":"cu_event_type","embeddable":true,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/cu_event_type?post=3745"},{"taxonomy":"cu_event_audience","embeddable":true,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/cu_event_audience?post=3745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}