{"id":14737,"date":"2024-02-07T10:11:02","date_gmt":"2024-02-07T15:11:02","guid":{"rendered":"https:\/\/carleton.ca\/biology\/?p=14737"},"modified":"2026-02-23T15:51:42","modified_gmt":"2026-02-23T20:51:42","slug":"feb-9-seminar-quebec-neutrophil","status":"publish","type":"post","link":"https:\/\/carleton.ca\/biology\/2024\/feb-9-seminar-quebec-neutrophil\/","title":{"rendered":"Feb 9: Seminar Quebec+ Neutrophil"},"content":{"rendered":"\n
\n
\n\n
\n
\n
\n

\n Feb 9: Seminar Quebec+ Neutrophil\n <\/h1>\n \n \n <\/header>\n\n <\/div>\n\n <\/div>\n\n <\/div>\n<\/section>\n\n

Hi everyone,  POSTER FOUND HERE<\/a><\/p>\n\n\n\n

Hope you are having a great start to 2024 so far.<\/p>\n\n\n\n

This Friday, Februa<\/strong>ry 9th<\/sup> <\/strong>at 9 AM<\/strong>, Joey Heath, postdoctoral fellow at the lab of Dr. Josie Ursini Siegel at the Lady Davis Institute for Medical Research in McGill University, will be giving a talk entitled \u201c<\/em>Directing Granulocytic Networks to Orchestrate Metabolic Sensitivity in Breast Cancer: Adjusting the Spotlight on Anti-Tumor Neutrophils<\/em><\/strong>\u201d as part of Quebec+ Neutrophil Meetings.<\/p>\n\n\n\n

Abstract of talk:<\/u> The tumor microenvironment (TME) is a complex arms race composed of host immune cells, stroma, and ever-adapting cancer cells. Comprising major components of the TME, exploiting tumor-associated inflammation has long been sought for therapeutic purposes. Our group identified inflammatory responses in breast cancer cells that elicit sensitivity to oxidative stressors, namely the complex I inhibitor, phenformin. In our immune-competent murine breast cancer models, sensitivity to phenformin was modest. However, sensitivity was largely improved when combined with TLR3\/4 agonists (the dsRNA-mimic, poly I:C; or the synthetic lipid A analog, CRX527). Given the large role of the innate immune system in the generation of this pathogen-associated inflammation, we analyzed systemic and tumor-infiltrating leukocyte diversity in our models by single- cell RNA-sequencing and flow cytometry. Combination therapy induced the expansion of specific CD11b+ Ly6G+ neutrophil populations in the blood and the TME. Using high- throughput proteomics, we highlight differential granule production and frequency which correlates with increased ROS production in cancer cells and synergizes with complex I inhibitors. The granulocyte-dependent tumoricidal synergy between oxidative stress and inflammation has not yet been described, establishing these findings as novel additions to the field of tumor-immune biology.<\/p>\n\n\n\n

Zoom Link: https:\/\/mcgill.zoom.us\/j\/8142546865?omn=83120560843&from=addon<\/a><\/p>\n\n\n\n

Meeting ID: 814 254 6865<\/p>\n\n\n\n

Hope to see you there.<\/p>\n","protected":false},"excerpt":{"rendered":"

Hi everyone,  POSTER FOUND HERE Hope you are having a great start to 2024 so far. This Friday, February 9th at 9 AM, Joey Heath, postdoctoral fellow at the lab of Dr. Josie Ursini Siegel at the Lady Davis Institute for Medical Research in McGill University, will be giving a talk entitled \u201cDirecting Granulocytic Networks to Orchestrate […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[68],"tags":[],"class_list":["post-14737","post","type-post","status-publish","format-standard","hentry","category-undergrad-opportunities"],"acf":{"cu_post_thumbnail":"event-lecture"},"_links":{"self":[{"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/posts\/14737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/comments?post=14737"}],"version-history":[{"count":2,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/posts\/14737\/revisions"}],"predecessor-version":[{"id":14789,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/posts\/14737\/revisions\/14789"}],"wp:attachment":[{"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/media?parent=14737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/categories?post=14737"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/carleton.ca\/biology\/wp-json\/wp\/v2\/tags?post=14737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}