Speaker: Dr. Shan Zou, Team Leader for Nanoscale Measurement, Metrology Research Centre, National Research Council Canada
Title: Nanomechanical Measurements for Characterization and Toxicity Assessment of Nanomaterials
Date, Time and Place: Friday, Nov. 16, 2018, 10 am, TB 238
Significant advances in nanometrology, the science of measurement at the nanoscale, are crucial for the continued development of nanotechnology-based consumer products. New and integrated measurement approaches with higher spatial resolution, accuracy and sensitivity are essential to fully characterize the nanomaterials. At the same time, many questions have been raised relating to the potential impact of nanomaterials on human health and the environment.
The development of new measurement methods combined with monitoring toxic responses using cellular model and assay systems will likely provide insight in to the risk assessment of nanomaterials. An AFMbased approach to investigate compound induced ion-channel effects on spontaneous beating iPSC derived cardiomyocytes is developed for pre-screening drug development and serves as a cellular model system for nanosafety and nanomaterial toxicity evaluation. Cell assay based viability tests and the correlation to the morphology of nanomaterials, such as graphene oxide and boron nitride nanotubes, for assessing toxicity, processing and compositions will also be discussed.
References:
1. Chen A.T.; Zou S. Analyst 2016,141, 6303.
2. Coleman, B.; Knight, T.; Gies, V.; Jakubek, Z.; Zou, S. ACS Appl. Mater. Interfaces 2017, 9,
28911.
3. Gies, V.; Zou, S. Toxicol. Res., 2018, 7, 93.
4. Gies, V.; Lopinski, G.; Augustine, J.; Cheung, T.; Kodra, O.; Zou, S. Nanoscale Adv. 2018.