Speaker: Prof. Lekha Sleno, UQAM.
Title: Studying Reactive Metabolites by Mass Spectrometry
Date, Time and Place: Friday March 15, 2019, TB 202
Reactive metabolites of drugs and other xenobiotics can deplete our antioxidant glutathione levels and covalently bind to proteins, which can lead to liver toxicity. This presentation will outline the different ways mass spectrometry can be used to study the formation of the reactive species, their protein targets and the related perturbations in metabolism. We use a combination of untargeted and targeted liquid chromatography-mass spectrometry workflows for the characterization and quantitation of metabolites and peptides for this work.
Biography:
2002 BSc Biochemistry (co-op) from Concordia University (Montreal)
2006 PhD Dalhousie University in Analytical Chemistry (small molecule mass
spectrometry) with Dietrich Volmer at NRC-Marine Biosciences in Halifax, NS
2006-2007 Post-Doc at the University of Geneva (Switzerland) in Pharmaceutical Mass Spectrometry with Gerard Hopfgartner (reactive drug metabolites)
2007-2008 Post-Doc at University of Toronto with Andrew Emili in Proteomics (small-molecule-protein interactions) at the Donnelly CCBR
2008-present Professor in the chemistry department at UQAM in Bioanalytical Chemistry, recently promoted to Full professor
Current UQAM Bioanalytical Strategic Research Chair
Current CSMS President
Director of CERMO-FC