The Weston Brain Institute (the “Institute”) supports research that accelerates the development of therapeutics for neurodegenerative diseases of aging. To help achieve this, the Institute addresses gaps and inefficiencies in the funding market by supporting high-risk, high-reward translational projects, while leveraging world-class business and scientific expertise in a fast and flexible granting process.

Neurodegenerative diseases of aging are among the least understood and most undertreated diseases today. Diseases such as Alzheimer’s and Parkinson’s are placing a large and increasing burden on society. If ignored, the social and economic costs to manage these diseases will rise significantly within a generation.

Based on success of previous programs, the Institute is expanding our support to new formats while maintaining the same mandate of accelerating the developments of therapeutics for neurodegenerative diseases of aging through translational research.

Opportunity

One format we are considering is supporting a large-scale research effort that would provide ~$5-20m over ~5 years in support of a large project(s). With this call, the Institute aims to identify highly impactful ideas for consideration.

Projects must have a significant and sustained impact on accelerating translational research on the development of therapeutics for neurodegenerative diseases of aging. Other project aspects are flexible, e.g.: – Submissions do not need to be fully developed at this stage – Submission do not need to be hypothesis based research questions – Participants can range from individual investigators/centres to international consortiums or collaborative projects

High potential projects may also (but not necessarily): – Be “flagship” projects for Canada, – Provide a platform for Canadian researchers to be recognized internationally – Bring international resources, people or organizations into Canadian-led work – Bring additional funding or other resources if/as needed

Eligibility

Applicant Eligibility: Eligible Principal Applicants must be working in Canada at least 30% of the time at or above the level of Assistant Professor or equivalent, and be affiliated with a Canada Revenue Agency-qualified donee institution located in Canada. Co-Applicants/Collaborators must be at the post-doctoral level or above and can be working outside Canada.

Applicants may appear in any role on any number of projects.

Project Eligibility: 

Submissions must:

  • Have a significant and sustained impact on translational research to accelerate the development of therapeutics for neurodegenerative diseases of aging.
  • Be led by Canadian-based researchers.

Projects must have a significant and sustained impact on accelerating translational research on the development of therapeutics for neurodegenerative diseases of aging.  Other project aspects are flexible, e.g.:

  • Submissions do not need to be fully developed at this stage
  • Submission do not need to be hypothesis based research questions
  • Participants can range from individual investigators/centres to international consortia or collaborative projects

High potential projects may also (but not necessarily):

  • Be “flagship” projects for Canada,
  • Provide a platform for Canadian researchers to be recognized internationally
  • Bring international resources, people or organizations into Canadian-led work
  • Bring additional funding or other resources if/as needed

Available Funding

  • From $5,000,000 to $20,000,000.

Useful Links

Deadlines

Opportunity

The Weston Brain Institute Postdoctoral Scholars at Oxford program supports top-tier Canadian postdoctoral scholars by providing international training at the University of Oxford and affiliation with Merton College. Prior to submitting an application, candidates should independently identify a host lab and potential supervisor at the University of Oxford who agrees to supervise them if awarded. Awardees will receive salary support for their postdoctoral positions at Oxford.

Goal: To encourage development of the next generation of leading Canadian neuroscientists by providing postdoctoral researchers with international training to accelerate their careers in translational research for neurodegenerative disease(s) of aging. Scholars should plan to build their careers in Canada upon completion of their postdoctoral position.

Eligibility

Applicant eligibility:

Applicants must be postdoctoral fellows who are normally resident in Canada, and plan to return to Canada to live and work upon completion of their postdoctoral position. They will have demonstrated outstanding scientific contributions, and will have the potential to be competitive for faculty positions in Canada following this postdoctoral position at Oxford.

Clinicians looking to complete a research position are eligible, but may not practice concurrently during their time at Oxford. Current PhD students considering this program for their first postdoctoral position should contact the Institute directly to discuss their eligibility.

If candidates are applying with a supervisor not focused on translational research for neurodegenerative diseases of aging, they are encouraged to seek a co-supervisor in the field.

Project eligibility: Projects must meet two conditions to be eligible:

  1. Be translational research that helps accelerate the development of therapeutics for neurodegenerative diseases of aging
  2. Be the development of a therapeutic and/or tool

The Institute defines neurodegenerative diseases of aging to include: Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies, frontotemporal dementia, multiple system atrophy, progressive supranuclear palsy, vascular contributions to the listed diseases (not stroke-mediated vascular disease), and prodromes to the listed diseases (e.g., mild cognitive impairment as prodromal to Alzheimer’s disease; REM sleep behavior disorder as prodromal to Parkinson’s disease). Proposed projects may relate to any disease(s), but must have an impact on neurodegenerative diseases of aging, and will be adjudicated based on their potential impact on these diseases.

To read how the Institute defines translational research, therapeutics and tools, please see What We Fund.

Funding Available

Up to ~$95,000CAD (£57,000, i.e. £44,000 per year + benefits) per year for 2 years

Internal Contacts

For proposal development/substantive review, please contact your Research Facilitator.

Deadlines

Faculty Deadline Please contact your Research Facilitator
OVPRI Approval Form Deadline Prior to submission of application to sponsor
Submission to Sponsor No Deadline

Applications are being accepted on a rolling basis. Applicants will be notified after submission of the next steps, which may include: Submitting a full application, discuss the idea further with the Institute, refine the idea in another LOI, collaborate on a shared project with other applicant, etc.

Submitting Your Application

  • Step 1) Submit an internal Carleton Approval Form
    Submit an internal Approval Form through our central awards management database CUResearch:
    https://ovpri.research.carleton.ca/Romeo.Researcher/Administrator/Default.aspx
    For a user’s guide on submitting an Approval Form, click here.
  • Step 2) Submit an external application to the granting agency
    Submit an external application to the corresponding grant or award agency. For further details about funding categories, eligibility criteria and deadlines for this opportunity, click here.