{"id":1256,"date":"2016-04-01T13:36:14","date_gmt":"2016-04-01T17:36:14","guid":{"rendered":"http:\/\/carleton.ca\/cosc\/?post_type=cu-people&#038;p=1256"},"modified":"2016-04-01T14:00:40","modified_gmt":"2016-04-01T18:00:40","slug":"alain-nepveu","status":"publish","type":"cu-people","link":"https:\/\/carleton.ca\/cosc\/people\/alain-nepveu\/","title":{"rendered":"Alain Nepveu"},"content":{"rendered":"<p><span style=\"text-decoration: underline;\">Research interests:<\/span>\u00a0Base Excision Repair of Oxidative DNA Damage: Dr. Nepveu&#8217;s\u00a0group has established that the CUX1 protein through its CUT domains functions as an accessory factor that stimulates the enzymatic activities of OGG1 and APE1, two enzymes of the base excision repair pathway that play important roles in the repair of oxidative DNA lesions. Mouse embryo fibroblasts from Cux1 knockout mice proliferate well in 3% oxygen, but immediately undergo senescence in 20% oxygen. 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