Dr. Bend\u2019s research investigates the molecular mechanisms by which endogenous and exogenous (xenobiotic) chemicals cause toxicity, and the mechanisms by which pre-existing pathological conditions such as oxidative stress\/infection, dramatically enhance this toxicity. His focus is on chemicals that exert their toxicity through activation of cell signaling networks (e.g. ligands for the aryl hydrocarbon receptor); to electrophilic metabolites of drugs or environmental contaminants which cause toxicity subsequent to covalent reaction with nucleophilic sites on proteins and nucleic acids; and to chemicals (bilirubin; sulfonamides, anti-epileptic drugs: POPs and heavy metals) that exert their toxicity by oxidative and\/or nitrosative stress. Studies are performed with compounds that are either of clinical (bilirubin; sulphamethoxazole) or environmental (methylmercury; polycyclic aromatic hydrocarbons; PCBs; heavy metals) significance.<\/p>\n","protected":false},"template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","_mi_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_links_to":"","_links_to_target":""},"people-type":[3],"yoast_head":"\n