Carleton Functional Proteomics Facility (CFPF)
Faculty: Science Department: Institute of Biochemistry
Overview: Using our peptide synthesis and array infrastructure, and our ability to functionally investigate protein interactions, we can synthesis custom peptide and peptide libraries, map epitopes and specificity for antibody/vaccine validation, and produce peptide arrays to accurately identify and quantify the molecular interactions.
Centre Capacity: Synthesis of custom peptides libraries and peptide arrays, biophysical/kinetic characterization of protein interactions, liquid handling infrastructure, tissue culture facilities, wet-bench sample preparation space and a fume hood.
Director: Dr. Kyle Biggar, Ph.D.
Focus: Life Sciences, Vaccine Development, Biopharmaceutical Development and Manufacturing
Project Examples: T-lymphocyte epitope mapping, Epitope selectivity and specificity of antibodies, Design and functional analysis of peptide-derived therapeutics, Synthesis of degenerate peptide libraries for inhibitor screening, Specificity and activity of kinase substrates, Characterization of protein recognition motifs by permutated/mutated peptide arrays.
Engagement types and co-funding
- R&D partnerships (up to 80% cash contributions available)
- Contract research and consulting
- Fee-for-service testing
- Industrial-partnered student internships (up to 50% cash contributions available)
- Quality control analysis
Point of Contact: Jeff Smirle, Business Manager- Faculty of Science