{"id":4234,"date":"2021-11-19T09:49:10","date_gmt":"2021-11-19T14:49:10","guid":{"rendered":"https:\/\/carleton.ca\/healthsciences\/?post_type=cu-events&#038;p=4234"},"modified":"2022-09-26T13:41:06","modified_gmt":"2022-09-26T17:41:06","slug":"utkarsh-dang","status":"publish","type":"cu-events","link":"https:\/\/carleton.ca\/healthsciences\/cu-events\/utkarsh-dang\/","title":{"rendered":"2021-22 Health Sciences Seminar Series &#8211; Dr. Utkarsh Dang"},"content":{"rendered":"<p>The Department of Health Sciences is pleased to announce the next seminar in our seminar series.<\/p>\n<p>Presenter: <strong>Dr. Utkarsh Dang<\/strong>, <span class=\"fontstyle0\">Assistant Professor, Department of Health Sciences, Carleton University<\/span><\/p>\n<p>Title: <span class=\"fontstyle0\">Serum Biomarkers and Clinical Severity in Young Steroid-Na\u00efve Duchenne Muscular Dystrophy Boys<\/span><\/p>\n<p><a href=\"https:\/\/carleton.ca\/healthsciences\/wp-content\/uploads\/figure_paper-image-for-poster.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-4256\" src=\"https:\/\/carleton.ca\/healthsciences\/wp-content\/uploads\/figure_paper-image-for-poster.png\" alt=\"\" width=\"1184\" height=\"764\" srcset=\"https:\/\/carleton.ca\/healthsciences\/wp-content\/uploads\/figure_paper-image-for-poster.png 1184w, https:\/\/carleton.ca\/healthsciences\/wp-content\/uploads\/figure_paper-image-for-poster-240x155.png 240w, https:\/\/carleton.ca\/healthsciences\/wp-content\/uploads\/figure_paper-image-for-poster-400x258.png 400w, https:\/\/carleton.ca\/healthsciences\/wp-content\/uploads\/figure_paper-image-for-poster-160x103.png 160w, https:\/\/carleton.ca\/healthsciences\/wp-content\/uploads\/figure_paper-image-for-poster-768x496.png 768w, https:\/\/carleton.ca\/healthsciences\/wp-content\/uploads\/figure_paper-image-for-poster-360x232.png 360w\" sizes=\"(max-width: 1184px) 100vw, 1184px\" \/><\/a><\/p>\n<p><\/p>\n<p><span class=\"fontstyle0\">Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin in muscle, and while all patients share the primary gene and biochemical defect, there is considerable patient\u2013patient variability in clinical symptoms. We developed multivariate models of serum protein biomarkers that explained observed variation, using functional outcome measures as proxies for severity. Serum samples from 39 steroid-na\u00efve DMD boys 4 to &lt;7 years enrolled into a clinical trial of vamorolone (NCT02760264) were studied. Weighted correlation network analysis was used<br \/>\nfor unsupervised clustering of 1305 proteins quantified using SOMAscan\u00ae aptamer profiling to define highly representative and connected proteins. Multivariate models of biomarkers were obtained for time to stand performance (strength phenotype; 17 proteins) and 6 min walk performance (endurance phenotype; 17 proteins) including some shared proteins. Identified proteins were further tested with associations of mRNA expression with histological severity of muscle from dystrophinopathy patients (n = 28) and normal controls (n = 6). We show that<br \/>\nperformance of DMD boys was effectively modeled with serum proteins, proximal strength associated with growth and remodeling pathways and muscle endurance centered on TGF<\/span><span class=\"fontstyle2\">\u03b2 <\/span><span class=\"fontstyle0\">and fibrosis pathways in muscle.<\/span><\/p>\n","protected":false},"template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","_mi_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_links_to":"","_links_to_target":""},"daevent-type":[48],"event-audience":[],"event-featured":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>2021-22 Health Sciences Seminar Series - Dr. Utkarsh Dang - Events - Health Sciences<\/title>\n<meta name=\"description\" content=\"The Department of Health Sciences is pleased to announce the next seminar in our seminar series. 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