{"id":4923,"date":"2023-12-18T13:10:22","date_gmt":"2023-12-18T18:10:22","guid":{"rendered":"https:\/\/carleton.ca\/healthsciences\/?post_type=cu-people&#038;p=4923"},"modified":"2025-06-09T09:33:46","modified_gmt":"2025-06-09T13:33:46","slug":"edana-cassol-2","status":"publish","type":"cu-people","link":"https:\/\/carleton.ca\/healthsciences\/people\/edana-cassol-2\/","title":{"rendered":"Edana Cassol (Admin)"},"content":{"rendered":"<h4>Primary field of Specialization:<\/h4>\n<p>Immunology, Infectious Disease and Immunometabolism<\/p>\n<h4>Research Interests:<\/h4>\n<p>My research uses a combination of immunological and biochemical approaches, tissue engineering and optical imaging to identify novel regulators of macrophage responses to viruses and bacteria across diverse tissue microenvironments. Our aim is to better understand these interactions to develop new therapeutics that target macrophage function to fine tune inflammatory processes, clear infection and restore healing and tissue homeostasis (e.g., chronic wounds and solid tumours).<\/p>\n<p>Current projects include:<\/p>\n<p><strong>PROJECT 1:<\/strong> Evaluating the role of mitochondrial reprogramming in antimicrobial immune responses.<\/p>\n<p><strong>PROJECT 2:<\/strong> Understanding how interactions between microbial communities and tissue macrophages contribute to delayed wound healing.<\/p>\n<p><strong>PROJECT 3:<\/strong> Targeting tumour associated macrophages with oncolytic viruses to restore anti-tumour immune responses.<\/p>\n<p><strong>PROJECT 4:<\/strong> Investigating how interactions between macrophages and fibroblasts in the lung contribute to the development of fibrosis and disease.<\/p>\n<h4>Select Publications:<\/h4>\n<p><strong>Label-free two-photon imaging of mitochondrial activity in murine macrophages stimulated with bacterial and viral ligands.<\/strong> Allen CH, Ahmed D, Raiche-Tanner O, Chauhan V, Mosta\u00e7o-Guidolin L, Cassol E, Murugkar S. Sci Rep. 2021 Jul 7;11(1):14081. doi: 10.1038\/s41598-021-93043-9.<\/p>\n<p><strong>Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation.<\/strong> Versey Z, da Cruz Nizer WS, Russell E, Zigic S, DeZeeuw KG, Marek JE, Overhage J, Cassol E. Front Immunol. 2021 Apr 9;12:648554. doi: 10.3389\/fimmu.2021.648554. eCollection 2021.<\/p>\n<p><strong>HIF-1\u03b1 Regulation of Cytokine Production following TLR3 Engagement in Murine Bone Marrow-Derived Macrophages Is Dependent on Viral Nucleic Acid Length and Glucose Availability<\/strong>. Ahmed D, Humphrey A, Roy D, Sheridan ME, Versey Z, Jaworski A, Edwards A, Donner J, Abizaid A, Willmore W, Kumar A, Golshani A, Cassol E.<\/p>\n<p><strong>Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages.<\/strong> Ahmed D, Roy D, Jaworski A, Edwards A, Abizaid A, Kumar A, Golshani A, Cassol E. Sci Rep. 2019 Dec 11;9(1):18801. doi: 10.1038\/s41598-019-55295-4.<\/p>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=cassol+E+and+hiv\">Click here<\/a> to access publications<\/h4>\n<p><\/p>\n<div class=\"slideme\"><dl class=\"slideme__list\"><dt class=\"slideme__term\"><a href=\"#slideme-faculty-fun-fact\" aria-expanded=\"false\" aria-controls=\"slideme-faculty-fun-fact\" class=\"slideme__heading slideme__trigger\">Faculty Fun Fact<\/a><\/dt><dd class=\"slideme__description\" id=\"slideme-faculty-fun-fact\" aria-hidden=\"true\"><p><\/p>\n<p>Edana has a significant interest in Global Health and as an undergraduate student interned with the Enhancing Care Initiative in Durban South Africa conducting epidemiological and field research on home based care for patients living with HIV and TB in rural communities. While there, she fell in love with the country, the people and the research and after graduation returned to South Africa to complete a Masters in Medical Science at the University of KwaZulu-Natal.<br \/>\n<\/p><\/dd><dl><\/div>\n","protected":false},"template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","_mi_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_links_to":"","_links_to_target":""},"people-type":[43],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Edana Cassol (Admin) - Health Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/carleton.ca\/healthsciences\/people\/edana-cassol-2\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/carleton.ca\/healthsciences\/people\/edana-cassol-2\/\",\"url\":\"https:\/\/carleton.ca\/healthsciences\/people\/edana-cassol-2\/\",\"name\":\"Edana Cassol (Admin) - Health Sciences\",\"isPartOf\":{\"@id\":\"https:\/\/carleton.ca\/healthsciences\/#website\"},\"datePublished\":\"2023-12-18T18:10:22+00:00\",\"dateModified\":\"2025-06-09T13:33:46+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/carleton.ca\/healthsciences\/people\/edana-cassol-2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/carleton.ca\/healthsciences\/people\/edana-cassol-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/carleton.ca\/healthsciences\/people\/edana-cassol-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/carleton.ca\/healthsciences\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"People\",\"item\":\"https:\/\/carleton.ca\/healthsciences\/people\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Edana Cassol (Admin)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/carleton.ca\/healthsciences\/#website\",\"url\":\"https:\/\/carleton.ca\/healthsciences\/\",\"name\":\"Health Sciences\",\"description\":\"Carleton University\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/carleton.ca\/healthsciences\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Edana Cassol (Admin) - 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