{"id":4686,"date":"2023-01-17T10:18:02","date_gmt":"2023-01-17T15:18:02","guid":{"rendered":"https:\/\/carleton.ca\/mae\/?post_type=cu_people&#038;p=4686"},"modified":"2025-08-14T13:53:31","modified_gmt":"2025-08-14T17:53:31","slug":"engkuan-moo","status":"publish","type":"cu_people","link":"https:\/\/carleton.ca\/mae\/people\/engkuan-moo\/","title":{"rendered":"Eng Kuan Moo"},"content":{"rendered":"<header class=\"mb-6 cu-pageheader cu-component-updated md:mb-12\">\n    <h1 class=\"cu-prose-first-last font-semibold !mt-2 mb-4 md:mb-6 text-3xl md:text-4xl lg:text-5xl lg:leading-[3.5rem] relative after:absolute after:h-px after:bottom-0 pb-5 after:w-10 after:bg-cu-red after:left-px\">\n                    \n             \n                \n            <\/h1>\n\n    \n    <\/header>\n\n\n\n<p><strong>Research Interests<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tissue and cell biomechanics<\/li>\n\n\n\n<li>Mechanobiology<\/li>\n\n\n\n<li>Microscopic imaging (confocal, multi-photon, atomic force, etc.)<\/li>\n\n\n\n<li>Continuum mechanics<\/li>\n\n\n\n<li>Finite element modelling<\/li>\n\n\n\n<li>Tissue engineering<\/li>\n\n\n\n<li>Fibre reinforcement of hydrogels<\/li>\n<\/ul>\n\n\n\n<p><strong>Research<\/strong><\/p>\n\n\n\n<p>I am interested in understanding the structure-composition-function relationships and cell-tissue interactions in soft connective tissues. I have worked with biological tissues such as articular cartilage and skeletal muscles. I answer my research questions through carefully designed&nbsp;<em>in vitro<\/em>,&nbsp;<em>in situ<\/em>&nbsp;and&nbsp;<em>in vivo<\/em>&nbsp;experiments and theoretical modelling. By understanding how mechanical forces are transduced through multi-scales to the cells, and how cells interact with the surrounding structural network in their native environment, I hope to apply this knowledge in the field of tissue engineering with the ultimate goal of bio-fabricating a viable and functional tissue substitute for patients who suffer from soft tissue injuries\/diseases.<\/p>\n\n\n\n<p><strong>Activities<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Adjunct Assistant Professor at the University of Calgary<\/li>\n<\/ul>\n\n\n\n<p><strong>Journal Articles<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Moo<\/strong>, E. K.; Ebrahimi, M.; Sibole, S. C.; Tanska, P.; Korhonen, R. K. The Intrinsic Quality of Proteoglycans, but Not Collagen Fibres, Degrades in Osteoarthritic Cartilage.\u00a0<em>Acta Biomaterialia<\/em>\u00a0<strong>2022<\/strong>,\u00a0<em>153<\/em>, 178\u2013189.\u00a0<a href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.actbio.2022.09.002&amp;data=05%7C01%7CMaiaGill%40cunet.carleton.ca%7Cb3dc4886d4ca4f46ba6608daf8a8bd9f%7C6ad91895de06485ebc51fce126cc8530%7C0%7C0%7C638095700858948026%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=xaXRv6I74lpIzVq1uquoTQoW8RjJSfqjUoxcSF7%2BTw8%3D&amp;reserved=0\">https:\/\/doi.org\/10.1016\/j.actbio.2022.09.002<\/a><\/li>\n\n\n\n<li>Sibole, S. C.<strong>*<\/strong>,\u00a0<strong>Moo<\/strong>, E. K.<strong>*<\/strong>,\u00a0Federico, S.,\u00a0Herzog, W. (2022)\u00a0The protective function of directed asymmetry in the pericellular matrix enveloping chondrocytes. Annals of Biomedical Engineering 50 (1): 39 \u2013 55, doi: 10.1007\/s10439-021-02900-1<\/li>\n\n\n\n<li>Karjalainen, K., Tanska, P., Sibole, S. C., Mikkonen, S., Herzog, W., Korhonen, R. K.,\u00a0<strong>Moo<\/strong>, E. K. (2022) Effect of cells on spatial quantification of proteoglycans in articular cartilage. Connective Tissue Research: 1 \u2013 12, doi: 10.1080\/03008207.2022.2048827<\/li>\n\n\n\n<li><strong>Moo<\/strong>, E. K.*, Al-Saffar, Y.*, Le, T., Seerattan, R. A., Pingguan-Murphy, B., Korhonen,\u00a0R. K.,\u00a0Herzog, W. (2021)\u00a0Deformation behaviors and mechanical impairments of tissue cracks in immature and mature cartilages.\u00a0<em>Journal of Orthopaedic Research<\/em>, doi: 10.1002\/jor.25243<\/li>\n\n\n\n<li><strong>Moo,<\/strong>\u00a0E. K., Tanska, P., Federico, S., Al-Saffar, Y., Herzog, W., Korhonen, R. K. (2021) Collagen fibres determine the crack morphology in articular cartilage.\u00a0<em>Acta Biomaterialia<\/em>\u00a0126: 301\u2013314, doi:10.1016\/j.actbio.2021.03.031<\/li>\n\n\n\n<li><strong>Moo<\/strong>, E. K., Leonard, T.R., Herzog, W. (2020) The sarcomere force-length relationship in an intact muscle-tendon unit.\u00a0<em>Journal of Experimental Biology<\/em>, 223 (6): jeb215020, doi: 10.1242\/jeb.215020<\/li>\n\n\n\n<li><strong>Moo<\/strong>, E. K.<strong>*<\/strong>, Sibole, S. C.<strong>*<\/strong>, Han, S. K., Herzog, W. (2017) Three-dimensional micro-scale strain mapping in living biological soft tissues.\u00a0<em>Acta Biomaterialia,<\/em>\u00a070: 260-269, doi: 10.1016\/j.actbio.2018.01.048<\/li>\n\n\n\n<li><strong>Moo<\/strong>, E. K., Herzog, W.\u00a0(2017)\u00a0Unfolding of membrane ruffles protects chondrocytes against death.\u00a0<em>Journal of Orthopaedic Research<\/em>, 35(2), 302-310, doi: 10.1002\/jor.23260<\/li>\n\n\n\n<li><strong>Moo<\/strong>, E.K., Amrein, M., Epstein, M., Duvall, M., Abu Osman, N.A., Pingguan-Murphy, B., Herzog, W.\u00a0(2013). The properties of chondrocyte membrane reservoirs and their role in impact-induced cell death.\u00a0<em>Biophysical Journal<\/em>, 105(7), 1590-1600, doi: 10.1016\/j.bpj.2013.08.035<\/li>\n\n\n\n<li><strong>Moo<\/strong>, E. K., Herzog, W., Han, S. K., Abu Osman, N. A., Pingguan-Murphy, B., Federico, S. (2012). Mechanical behaviour of in-situ chondrocytes subjected to different loading rates: a finite element study.\u00a0<em>Biomechanics and Modeling in Mechanobiology<\/em>, 11(7), 983-93, doi: 10.1007\/s10237-011-0367-2<\/li>\n<\/ol>\n\n\n\n<p>* Authors contributed equally to the research work<\/p>\n","protected":false},"author":2,"featured_media":4688,"template":"","meta":{"_acf_changed":false,"cu_people_first_name":"Eng Kuan","cu_people_last_name":"Moo","cu_people_initials":"","footnotes":"","_links_to":"","_links_to_target":""},"cu_people_type":[13],"cu_people_expertise":[],"class_list":["post-4686","cu_people","type-cu_people","status-publish","has-post-thumbnail","hentry","cu_people_type-faculty"],"acf":{"cu_people_job_title":"Assistant Professor","cu_people_degree":"Ph.D. (University of Malaya)","cu_building":"ME","cu_people_office_num":"3250","cu_people_pronoun":"","cu_people_designation":"","cu_people_email":"EngKuanMoo@cunet.carleton.ca","cu_people_phone":"613-520-2600","cu_people_phone_ext":"1379","cu_people_linkedin":"","cu_people_bluesky":"","cu_people_twitter":"","cu_people_instagram":"","cu_people_facebook":"","cu_people_website":"https:\/\/carleton.ca\/mubest-lab\/","cu_people_orcid":""},"_links":{"self":[{"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/cu_people\/4686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/cu_people"}],"about":[{"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/types\/cu_people"}],"author":[{"embeddable":true,"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/users\/2"}],"version-history":[{"count":3,"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/cu_people\/4686\/revisions"}],"predecessor-version":[{"id":7804,"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/cu_people\/4686\/revisions\/7804"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/media\/4688"}],"wp:attachment":[{"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/media?parent=4686"}],"wp:term":[{"taxonomy":"cu_people_type","embeddable":true,"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/cu_people_type?post=4686"},{"taxonomy":"cu_people_expertise","embeddable":true,"href":"https:\/\/carleton.ca\/mae\/wp-json\/wp\/v2\/cu_people_expertise?post=4686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}