{"id":72236,"date":"2020-12-14T14:41:11","date_gmt":"2020-12-14T19:41:11","guid":{"rendered":"https:\/\/newsroom.carleton.ca\/?post_type=cu_story&#038;p=72236"},"modified":"2025-08-19T09:37:17","modified_gmt":"2025-08-19T13:37:17","slug":"hibernating-lemurs-space-travel","status":"publish","type":"cu_story","link":"https:\/\/carleton.ca\/news\/story\/hibernating-lemurs-space-travel\/","title":{"rendered":"Hibernating lemurs may be the key to cryogenic sleep for human space travel"},"content":{"rendered":"\n<section class=\"w-screen px-6 cu-section cu-section--white ml-offset-center md:px-8 lg:px-14\">\n    <div class=\"space-y-6 cu-max-w-child-max  md:space-y-10 cu-prose-first-last\">\n\n        \n                    \n                    \n            \n    <div class=\"cu-wideimage relative flex items-center justify-center mx-auto px-8 overflow-hidden md:px-16 rounded-xl not-prose  my-6 md:my-12 first:mt-0 bg-opacity-50 bg-cover bg-cu-black-50 pt-24 pb-32 md:pt-28 md:pb-44 lg:pt-36 lg:pb-60 xl:pt-48 xl:pb-72\" style=\"background-image: url(https:\/\/carleton.ca\/news\/wp-content\/uploads\/sites\/162\/hibernating-lemurs-1200w-1.jpg); background-position: 50% 50%;\">\n\n                    <div class=\"absolute top-0 w-full h-screen\" style=\"background-color:rgba(0,0,0,0.600);\"><\/div>\n        \n        <div class=\"relative z-[2] max-w-4xl w-full flex flex-col items-center gap-2 cu-wideimage-image cu-zero-first-last\">\n            <header class=\"mx-auto mb-6 text-center text-white cu-pageheader cu-component-updated cu-pageheader--center md:mb-12\">\n\n                                    <h1 class=\"cu-prose-first-last font-semibold mb-2 text-3xl md:text-4xl lg:text-5xl lg:leading-[3.5rem] cu-pageheader--center text-center mx-auto after:left-px\">\n                        Hibernating lemurs may be the key to cryogenic sleep for human space travel\n                    <\/h1>\n                \n                            <\/header>\n        <\/div>\n\n                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"absolute bottom-0 w-full z-[1]\" fill=\"none\" viewbox=\"0 0 1280 312\">\n                <path fill=\"#fff\" d=\"M26.412 315.608c-.602-.268-6.655-2.412-13.524-4.769a1943.84 1943.84 0 0 1-14.682-5.144l-2.276-.858v-5.358c0-4.876.086-5.358.773-5.09 1.674.643 21.38 5.84 34.646 9.109 14.682 3.59 28.935 6.858 45.936 10.449l9.874 2.089H57.322c-16.4 0-30.31-.16-30.91-.428ZM460.019 315.233c42.974-10.074 75.602-19.88 132.443-39.867 76.16-26.791 152.063-57.709 222.385-90.663 16.7-7.823 21.336-10.074 44.262-21.273 85.004-41.688 134.719-64.193 195.291-88.413 66.55-26.577 145.2-53.584 194.27-66.765C1258.5 5.626 1281.34 0 1282.24 0c.17 0 .34 27.596.34 61.3v61.299l-2.23.375c-84.7 13.718-165.93 35.955-310.736 84.931-46.494 15.753-65.427 22.076-96.166 32.15-9.102 3-24.814 8.198-34.989 11.574-107.543 35.954-153.008 50.422-196.626 62.639l-6.74 1.876-89.126-.054c-78.135-.054-88.782-.161-85.948-.857ZM729.628 312.875c33.229-10.985 69.248-23.523 127.506-44.207 118.705-42.223 164.596-57.709 217.446-73.302 2.62-.75 8.29-2.465 12.67-3.751 56.19-16.772 126.94-33.597 184.17-43.671 5.07-.91 9.66-1.768 10.22-1.875l.94-.161v170.236l-281.28-.054H719.968l9.66-3.215ZM246.864 313.411c-65.041-2.251-143.047-12.11-208.432-26.256-18.375-3.965-41.73-9.538-42.202-10.074-.171-.214-.257-21.38-.214-47.046l.129-46.618 6.654 3.697c57.313 32.043 118.491 56.531 197.699 79.143 40.313 11.521 83.459 18.058 138.669 21.059 15.584.857 65.685.857 81.14 0 33.744-1.876 61.306-4.93 88.396-9.806 6.396-1.126 11.634-1.983 11.722-1.929.255.375-20.48 7.769-30.999 11.038-28.592 8.948-59.288 15.646-91.873 20.147-26.36 3.59-50.015 5.627-78.35 6.698-15.584.59-55.209.59-72.339-.053Z\"><\/path>\n                <path fill=\"#fff\" d=\"M-3.066 295.067 32.06 304.1v9.033H-3.066v-18.066Z\"><\/path>\n            <\/svg>\n            <\/div>\n\n    \n\n    <\/div>\n<\/section>\n\n<p>Science fiction is shifting into reality. With humanity\u2019s plans to <a href=\"https:\/\/www.nasa.gov\/topics\/moon-to-mars\/overview\" target=\"_blank\" rel=\"noopener noreferrer\">return to the moon this decade<\/a> and further ambitions to travel to Mars in the next, we need to figure out how to keep astronauts healthy for these years-long missions. One solution long championed by science fiction is suspended animation, or putting humans in a hibernation-like sleep for the duration of travel time. <\/p>\n\n\n\n<p>We can turn to nature for guidance and a potential solution to this challenge.<\/p>\n\n\n\n<figure class=\"wp-block-image align-center zoomable\"><a href=\"https:\/\/images.theconversation.com\/files\/374268\/original\/file-20201210-19-1jm1k1u.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip\"><img decoding=\"async\" src=\"https:\/\/images.theconversation.com\/files\/374268\/original\/file-20201210-19-1jm1k1u.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip\" alt=\"A squirrel monkey sits on top of a model rocket.\"\/><\/a><figcaption class=\"wp-element-caption\">\n              <span class=\"caption\">Primates have been used in space research for decades. Space pioneer Miss Baker, a squirrel monkey, rode a Jupiter IRBM into space in 1959 and returned safely.<\/span><br>\n              <span class=\"attribution\"><a class=\"source\" href=\"http:\/\/mix.msfc.nasa.gov\/abstracts.php?p=886\" target=\"_blank\" rel=\"noopener noreferrer\">(NASA\/Marshall Space Flight Center)<\/a><\/span><br>\n            <\/figcaption><\/figure>\n\n\n\n<h2 id=\"its-cold-and-dark-out-there\" class=\"wp-block-heading\">It\u2019s cold and dark out there<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p>Space is unforgiving. In this freezing void of darkness there is no oxygen, no gravity and no protection against the constant shower of cosmic radiation. Humans have <a href=\"https:\/\/doi.org\/10.1007\/978-3-642-59381-9_21\" target=\"_blank\" rel=\"noopener noreferrer\">evolved under a constant gravitational pull<\/a> \u2014 so when you put people into space, strange and dangerous things happen to their bodies. <\/p>\n\n\n\n<p>However, scientists and engineers working with astronauts on the International Space Station have innovated and continue to address these problems. For example, we know that spaceflight leads to <a href=\"https:\/\/doi.org\/10.1007\/s00421-012-2523-5\" target=\"_blank\" rel=\"noopener noreferrer\">loss of muscle and bone density<\/a>, since our bones and muscles do not need to work against the pull of gravity to move us around. <\/p>\n\n\n\n<p>But we still do not know how to address other space-related medical issues, including <a href=\"https:\/\/doi.org\/10.3389\/fimmu.2018.01437\" target=\"_blank\" rel=\"noopener noreferrer\">immune system alterations<\/a>, <a href=\"https:\/\/doi.org\/10.1016\/j.ophtha.2011.06.021\" target=\"_blank\" rel=\"noopener noreferrer\">problems with vision<\/a> and bombardment with <a href=\"https:\/\/doi.org\/10.3390\/life4030491\" target=\"_blank\" rel=\"noopener noreferrer\">hazardous cosmic radiation<\/a>. <\/p>\n\n\n\n<p>These physiological challenges are combined with the technological difficulties of sending multiple humans on these long missions where they face logistical complications of packing and allocating enough provisions and supplies, as well as social issues of coping with extreme isolation in deep space. <\/p>\n\n\n\n<h2 id=\"putting-the-body-on-pause\" class=\"wp-block-heading\">Putting the body on pause<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p>Suspended animation and <a href=\"https:\/\/doi.org\/10.1111\/febs.14683\" target=\"_blank\" rel=\"noopener noreferrer\">biostasis<\/a> may elicit science fiction images of humans in cryosleep pods. If we could put humans in a state of suspended animation by greatly slowing or even fully halting metabolic activity, we could alleviate issues surrounding space travel: time, health concerns, spacecraft size and supply allocation.<\/p>\n\n\n\n<figure>\n            <iframe loading=\"lazy\" width=\"688\" height=\"407\" src=\"https:\/\/www.youtube.com\/embed\/aGSMEhKPIeo?wmode=transparent&amp;start=0\" frameborder=\"0\" allowfullscreen=\"\"><\/iframe><figcaption><span class=\"caption\">WIRED takes a look at the science behind suspended animation.<\/span><\/figcaption><\/figure>\n\n\n\n<p>But how can we safely ease humans into hibernation and then bring them back when the time is right, without risking muscle and bone wasting, to name a few challenges? These are questions that the <a href=\"https:\/\/www.darpa.mil\/news-events\/2018-03-01\" target=\"_blank\" rel=\"noopener noreferrer\">United States Department of Defense<\/a> and other space agencies are actively exploring. <\/p>\n\n\n\n<p>Animals who spend the winter in states of suspended animation \u2014 hibernation \u2014 don\u2019t experience significant muscle and bone wasting. Their existence and ability to reversibly turn off biological processes seemingly necessary for life may well hold the key to creating the conditions required for the human hibernation strategy that could pave our way to surviving long interstellar voyages to distant stars.<\/p>\n\n\n\n<p>In fact, the use of biostasis has already been proposed for the <a href=\"https:\/\/ntrs.nasa.gov\/citations\/20180007195\" target=\"_blank\" rel=\"noopener noreferrer\">transport of large numbers of travellers to Mars<\/a>, where crew members will be sustained with specially formulated total nutrition liquids while they \u201csleep.\u201d<\/p>\n\n\n\n<h2 id=\"model-animals\" class=\"wp-block-heading\">Model animals?<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p>How do we translate hibernation in animals to hibernation in humans? Recent work has uncovered such an ability in animals that are evolutionarily similar to humans: <a href=\"https:\/\/doi.org\/10.1016\/j.gpb.2015.06.001\" target=\"_blank\" rel=\"noopener noreferrer\">hibernating primates<\/a>. What is unique about these primates is that they can enter a state of hibernation when resources are scarce and temperatures become cold, and do so without seriously dropping their body temperature.     <\/p>\n\n\n\n<p>One of the driving forces behind this extreme ability is microRNAs \u2014 short pieces of RNA that act as molecular gene silencers. MicroRNAs can regulate gene expression without altering the genetic code itself. By studying the microRNA strategy these animals use, we can exploit this genetic on\/off switch for rapid, reversible changes that could aid hibernation in humans. <\/p>\n\n\n\n<p>Our work on gray mouse lemurs (<em>Microcebus murinus<\/em>) shows how <a href=\"https:\/\/doi.org\/10.1016\/j.bbagrm.2019.194473\" target=\"_blank\" rel=\"noopener noreferrer\">microRNAs control which biological processes remain on<\/a> to protect the animal and which ones are switched off to save energy. Some of these microRNAs were found to combat muscle wasting during hibernation. Other roles seem to involve preventing cell death, slowing down or stopping unnecessary cell growth, and switching fuel stores from quickly consumed sugars to slower-burned fats.<\/p>\n\n\n\n<p>While microRNAs are a promising avenue of research, they are just one piece of the puzzle. Our lab is also looking into other aspects of how primates hibernate, such as how these lemurs <a href=\"https:\/\/doi.org\/10.1016\/j.gpb.2015.03.004\" target=\"_blank\" rel=\"noopener noreferrer\">protect their cells from stress<\/a>, <a href=\"https:\/\/doi.org\/10.1016\/j.gpb.2015.03.003\" target=\"_blank\" rel=\"noopener noreferrer\">control global gene levels<\/a> and how <a href=\"https:\/\/doi.org\/10.1016\/j.gpb.2015.03.006\" target=\"_blank\" rel=\"noopener noreferrer\">they store enough energy to survive hibernation<\/a>.<\/p>\n\n\n\n<figure>\n            <iframe loading=\"lazy\" width=\"688\" height=\"407\" src=\"https:\/\/www.youtube.com\/embed\/h_bNO7MelXI?wmode=transparent&amp;start=0\" frameborder=\"0\" allowfullscreen=\"\"><\/iframe><figcaption><span class=\"caption\">Mouse lemurs are more closely related to humans than mice, which are more typically used for research.<\/span><\/figcaption><\/figure>\n\n\n\n<p>Our lab also looks at how <a href=\"https:\/\/doi.org\/10.1242\/jeb.104828\" target=\"_blank\" rel=\"noopener noreferrer\">microRNAs are helping animals survive other extreme environmental stresses<\/a> including freezing, oxygen-deprivation and hot, dry climates. There is no stress more extreme than the vacuum of space, and we hope our research will contribute to the new RNA-based interventions that are gaining attention and emerging as viable human therapeutics.<\/p>\n\n\n\n<p>Space is within our reach, and studying what\u2019s already on Earth will help get us there.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n\n\n\n<p>This article is republished from <a href=\"https:\/\/theconversation.com\/institutions\/carleton-university-900\" target=\"_blank\" rel=\"noopener noreferrer\">The Conversation<\/a> under a Creative Commons license. Carleton University is a member of this unique digital journalism platform that launched in June 2017 to boost visibility of Canada\u2019s academic faculty and researchers. Interested in writing a piece? Please contact <a href=\"mailto:steven.reid3@carleton.ca\">Steven Reid<\/a> or <a href=\"https:\/\/theconversation.com\/become-an-author\" target=\"_blank\" rel=\"noopener noreferrer\">sign up to become an author<\/a>.<\/p>\n\n\n\n<p><em>All photos provided by The Conversation from various sources.<\/em><\/p>\n\n\n\n<p>&#8212;<br>\n<a href=\"https:\/\/newsroom.carleton.ca\/\">Carleton Newsroom<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/counter.theconversation.com\/content\/148408\/count.gif?distributor=republish-lightbox-basic\" alt=\"The Conversation\"\/><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science fiction is shifting into reality. With humanity\u2019s plans to return to the moon this decade and further ambitions to travel to Mars in the next, we need to figure out how to keep astronauts healthy for these years-long missions. One solution long championed by science fiction is suspended animation, or putting humans in a [&hellip;]<\/p>\n","protected":false},"author":410,"featured_media":72246,"template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"cu_story_type":[1623],"cu_story_tag":[],"class_list":["post-72236","cu_story","type-cu_story","status-publish","has-post-thumbnail","hentry","cu_story_type-expert-perspectives"],"acf":{"cu_post_thumbnail":"blueprint"},"_links":{"self":[{"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/cu_story\/72236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/cu_story"}],"about":[{"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/types\/cu_story"}],"author":[{"embeddable":true,"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/users\/410"}],"version-history":[{"count":3,"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/cu_story\/72236\/revisions"}],"predecessor-version":[{"id":72248,"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/cu_story\/72236\/revisions\/72248"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/media\/72246"}],"wp:attachment":[{"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/media?parent=72236"}],"wp:term":[{"taxonomy":"cu_story_type","embeddable":true,"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/cu_story_type?post=72236"},{"taxonomy":"cu_story_tag","embeddable":true,"href":"https:\/\/carleton.ca\/news\/wp-json\/wp\/v2\/cu_story_tag?post=72236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}