{"id":138,"date":"2016-10-06T14:06:34","date_gmt":"2016-10-06T18:06:34","guid":{"rendered":"http:\/\/carleton.ca\/smithlab\/?page_id=138"},"modified":"2026-09-21T14:57:46","modified_gmt":"2026-09-21T18:57:46","slug":"publications","status":"publish","type":"page","link":"https:\/\/carleton.ca\/smithlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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\n Publications\n <\/h1>\n \n \n <\/header>\n\n <\/div>\n\n <\/div>\n\n <\/div>\n<\/section>\n\n\n\n

Published Research Articles<\/h2>\n\n\n\n
    \n
  1. Menard, J.A., Roberts, J.A., Clarke, J.H., Rudd, K.E.A., Rosales, C.A., Smith, J.C.<\/strong> (2026) LC-MS FADE: Leveraging Untargeted Lipidomics Data for Fatty Acid Profiling. 98(28):20789\u201320800. doi: 10.1021\/acs.analchem.6c01325.<\/li>\n\n\n\n
  2. Menard, J.A., Zinnecker, T., Godbout, E., Roberts, J.A., Arulanandam, R., Chen, A., Landry, A., Boddy, C.N., Reichl, U., Diallo, J.-S., Genzel, Y., Smith, J.C.<\/strong> (2026) Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection. 16:882. doi: 10.1038\/s41598-025-33499-1.<\/li>\n\n\n\n
  3. Rosales, C.A., Lepinsky, N.A., Ramadan, M., Manthorpe, J.M., Jonz, M.G., Smith, J.C. <\/strong>(2025) Enhanced LC-MS Detection of \u03b3-Aminobutyric Acid via Trimethylation Enhancement Using Diazomethane. 36(12):2699\u20132706. doi: 10.1021\/jasms.5c00294.<\/li>\n\n\n\n
  4. Fulton, K.M., Mendoza-Barber\u00e0, E., Tom\u00e1s, J.M., Twine, S.M., Smith, J.C.<\/strong>, Merino, S. (2025) Polar flagellin glycan heterogeneity of Aeromonas hydrophila strain ATCC 7966T. 158:108300. doi: 10.1016\/j.bioorg.2025.108300.<\/li>\n\n\n\n
  5. Rosales, C.A., Lepinsky, N.A., Gebeyehu, W., Wasslen, K.V., Colquhoun, F., Warnes, B.B., Chihabi, J., Manthorpe, J.M., Smith, J.C.<\/strong> (2025) Improved LC-MS Detection of Opioids, Amphetamines, and Psychedelics Using TrEnDi. 36(3):514\u2013523. doi: 10.1021\/jasms.4c00382.<\/li>\n\n\n\n
  6. Roberts, J.A., Radnoff, A.S., Bushueva, A., Menard, J.A., Wasslen, K.V., Harley, M., Manthorpe, J.M., Smith, J.C.<\/strong> (2024) Mobile Phase Contaminants Affect Neutral Lipid Analysis in LC-MS-Based Lipidomics Studies. 35(12):3095\u20133106. doi: 10.1021\/jasms.4c00320.<\/li>\n\n\n\n
  7. Shields, S.W.J., Canez, C.R., Rosales, C.A., Roberts, J.A., Bourgaize, H., Pallister, P.J., Manthorpe, J.M., Smith, J.C. <\/strong>(2024) Optimized 13C TrEnDi Enhances the Sensitivity of Plasmenyl Ether Glycerophospholipids and Demonstrates Compatibility with Other Derivatization Strategies. 35(5):972\u2013981. doi: 10.1021\/jasms.4c00015.<\/li>\n\n\n\n
  8. Roberts, J.A., Godbout, E., Menard, J.A., Boddy, C.N., Diallo, J.-S., Smith, J.C. <\/strong>(2024) Comprehensive untargeted lipidomic profiling of third generation lentiviral vectors and packaging cells. 20(10):642\u2013653. doi: 10.1039\/d4mo00052h.<\/li>\n\n\n\n
  9. Rosales, C.A., Sheedy, K.L., Wasslen, K.V., Manthorpe, J.M., Smith, J.C.<\/strong> (2024) Trimethylation Enhancement Using Diazomethane (TrEnDi) Enables Enhanced Detection of Glufosinate and 3-(Methylphosphinico)propionic Acid from Complex Canola Samples. 35(1):140\u2013150. doi: 10.1021\/jasms.3c00376.<\/li>\n\n\n\n
  10. Roberts, J.A., Rosales, C.A., Wasslen, K.V., Radnoff, A.S., Godbout, E., Diallo, J.-S., Manthorpe, J.M., Smith, J.C.<\/strong> (2023) An In Silico Database for Automated Feature Identification of High-Resolution Tandem Mass Spectrometry 13C-Trimethylation Enhancement Using Diazomethane (13C TrEnDi)-Modified Lipid Data. 34(12):2722\u20132730. doi: 10.1021\/jasms.3c00273.<\/li>\n\n\n\n
  11. Rosales, C.A., Shields, S.W.J., Aulenback, C.L.J., Elezi, G., Wasslen, K.V., Pallister, P.J., Faull, K.F., Manthorpe, J.M., Smith, J.C.<\/strong> (2023) Improved Chromatography and MS-Based Detection of Glyphosate and Aminomethylphosphonic Acid Using iTrEnDi. 34(5):948\u2013957. doi: 10.1021\/jasms.3c00026.<\/li>\n\n\n\n
  12. Country, M.W., Haase, K., Blank, K., Canez, C.R., Roberts, J.A., Campbell, B.F.N., Smith, J.C.<\/strong>, Pelling, A.E., Jonz, M.G. (2022) Seasonal changes in membrane structure and excitability in retinal neurons of goldfish (Carassius auratus) under constant environmental conditions. 225(10):jeb244238. doi: 10.1242\/jeb.244238.<\/li>\n\n\n\n
  13. Forn-Cun\u00ed, G., Fulton, K.M., Smith, J.C.<\/strong>, Twine, S.M., Mendoza-Barber\u00e0, E., Tom\u00e1s, J.M., Merino, S. (2021) Polar Flagella Glycosylation in Aeromonas: Genomic Characterization and Involvement of a Specific Glycosyltransferase (Fgi-1) in Heterogeneous Flagella Glycosylation. 11:595697. doi: 10.3389\/fmicb.2020.595697.<\/li>\n\n\n\n
  14. Shields, S.W.J., Rosales, C.A., Roberts, J.A., Pallister, P.J., Wasslen, K.V., Manthorpe, J.M., Smith, J.C.<\/strong> (2021) iTrEnDi: In Situ Trimethylation Enhancement Using Diazomethane: Improved and Expanded Glycerophospholipid and Sphingolipid Analyses via a Microscale Autonomous Derivatization Platform. 93(2):1084\u20131091. doi: 10.1021\/acs.analchem.0c04088.<\/li>\n\n\n\n
  15. Franklin, E.T., Shields, S.W.J., Manthorpe, J.M., Smith, J.C.<\/strong>, Xia, Y., McLuckey, S.A. (2020) Coupling Headgroup and Alkene Specific Solution Modifications with Gas-Phase Ion\/Ion Reactions for Sensitive Glycerophospholipid Identification and Characterization. 31(4):938\u2013945. doi: 10.1021\/jasms.0c00001.<\/li>\n\n\n\n
  16. Jonz, M., Country, M., Blank, K. (2020) Action Potential Activity and Membrane Structure in Neurons of the Goldfish Retina Undergo Seasonal Changes. 118:457a.<\/li>\n\n\n\n
  17. Black, C., D’Souza, T., Smith, J.C.<\/strong>, Hearns, N.G.R. (2019) Identification of post-blast explosive residues using direct-analysis-in-real-time and mass spectrometry (DART-MS). 16:100185. doi: 10.1016\/j.forc.2019.100185.<\/li>\n\n\n\n
  18. Fulton, K.M., Li, J., Tomas, J.M., Smith, J.C.<\/strong>, Twine, S.M. (2018) Characterizing bacterial glycoproteins with LC-MS. 15(3):203\u2013216. doi: 10.1080\/14789450.2018.1435276.<\/li>\n\n\n\n
  19. Betancourt, S., Canez, C., Shields, S., Manthorpe, J., Smith, J.C.<\/strong>, McLuckey, S.  (2017) Trimethylation Enhancement Using 13<\/sup>C Diazomethane (13<\/sup>C-TrEnDi):  Gas-Phase Charge Inversion of Modified Phospholipid Cations for Enhanced Structural Characterization. 89(17):9452\u20139458. doi: <\/strong>10.1021\/acs.analchem.7b02271<\/li>\n\n\n\n
  20. Tessier, S.N., Luu, B.E., Smith, J.C.<\/strong>, Storey, K.B. (2017) The role of global histone post-translational modifications during mammalian hibernation. 75: 28-36.  doi: 10.1016\/j.cryobiol.2017.02.008<\/li>\n\n\n\n
  21. Fulton, K.M., Smith, J.C.<\/strong>, Twine, S.M.\u00a0 (2016) Clinical Applications of Bacterial Glycoproteins.\u00a0 Expert Review of Proteomics.\u00a0 13(4):345-53. doi: 10.1586\/14789450.2016.1166054.<\/li>\n\n\n\n
  22. Canez, C.R., Shields, S.W.J., Bugno, M., Wasslen, K.V., Willmore, W.G., Manthorpe, J.M., Smith, J.C.<\/strong> (2016) Trimethylation enhancement using 13C-diazomethane (13C-TrEnDi): Increased sensitivity and selectivity of phosphatidylethanolamine, phosphatidylcholine and phosphatidylserine lipids derived from complex biological samples. Analytical Chemistry. Jul 19;88(14):6996-7004. doi: 10.1021\/acs.analchem.5b04524.<\/li>\n\n\n\n
  23. Dornan, M.H., Krishnan, R., Macklin, A.M., Selman, M., El Sayes, N., Hee Son, H., Davis, C., Chen, A., Keillor, K., Le, P., Moi, C., Ou, P., Pardin, C., Canez, C.R., Le Boeuf, F., Bell, J.C., Smith, J.C.,*<\/strong> Diallo, J-S.,* Boddy, C.N.* (2016) First-in-class small molecule potentiators of cancer virotherapy. Nature Scientific Reports.  May 26;6:26786. doi: 10.1038\/srep26786. PMID: 27226390. (* – co-corresponding authorship).<\/li>\n\n\n\n
  24. Farmer, K., Smith, C., Hayley, S., Smith, J.C. <\/strong>(2015) Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson\u2019s Disease.  International journal of molecular sciences. Aug 12;16(8): 18865-18877. PMID: 26274953.<\/li>\n\n\n\n
  25. Smith, C., Farmer, K., Lee, H., Hollohan, M., Smith, J.C. <\/strong>(2015) Altered hippocampal lipid profile following acute postnatal exposure to di(2-ethylhexyl) phthalate in rats. International journal of environmental research and public health.  Oct 27;12(10): 13542-13559.  PMID: 26516880.<\/li>\n\n\n\n
  26. Bell, R., Smith, J.C.,<\/strong> Storey, K.B. (2014) Purification and properties of glyceraldehyde-3-phosphate dehydrogenase from the skeletal muscle of the hibernating ground squirrel, Ictidomys tridecemlineatus<\/em>.  Oct 28;2:e634. doi: 10.7717\/peerj.634. eCollection 2014. PMID: 25374779.<\/li>\n\n\n\n
  27. Wasslen, K.V., Canez, C.R., Lee, H., Manthorpe, J.M., Smith, J.C.<\/strong> (2014) Trimethylation Enhancement using Diazomethane (TrEnDi) II: Rapid In-Solution Concomitant Quaternization of Glycerophospholipid Amino Groups and Methylation of Phosphate Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge. Analytical Chemistry. Oct 7;86(19): 9523-9532. DOI: 10.1021\/ac501588y. PMID: 25208053.<\/li>\n\n\n\n
  28. Wasslen, K.V., Tan, L.H., Manthorpe, J.M., Smith, J.C.<\/strong> (2014) Trimethylation Enhancement using Diazomethane (TrEnDi): Rapid On-Column Quaternization of Peptide Amino Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge. Analytical Chemistry.  Apr 1;86(7):3291-9. doi:10.1021\/ac403349c. PMID: 24555738.<\/li>\n\n\n\n
  29. Chao, S., Green, J.R., Smith, J.C.<\/strong> (2014) Evaluation of a GPGPU-based de novo peptide sequencing algorithm. Journal of Medical and Biological Engineering. Jan 1; 34(5): 461-468. doi:10.5405\/jmbe.1713.<\/li>\n\n\n\n
  30. Wasslen, K., Wood, S., Manthorpe, J., Smith, J.C. <\/strong>(2013) Trimethylation enhancement using diazomethane (TrEnDi): Rapid on-column methylation of peptides and proteins to permit quantitative analysis using tandem mass spectrometry.  Rapid Communications in Mass Spectrometry.  27(22):2576.   Extended abstract from the 7th International Symposium on Enabling Technologies at the Metro Toronto Convention Centre, Toronto, ON on April 30th<\/sup>, 2013.<\/li>\n\n\n\n
  31. Smith, B.K., Perry, C.G.R., Herbst, E.A., Ritchie, I.R., Beaudoin, M-S., Smith, J.C.<\/strong>, Neufer, P.D., Wright, D.C., Holloway, G.P. (2013)  Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol.  Journal of Physiology. 591(Pt 23):6089-6101.  PMID: 24081154<\/li>\n\n\n\n
  32. Frahm, G.E., Eastwood, G., Cameron, B.E., Smith, J.C.<\/strong>, Johnston, M.J.W. (2013) Generation of fatty acids from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine\/cardiolipin liposomes that stabilize recombinant human serum albumin. Journal of Liposome Research.  23(2):101-109. PMID: 23294393.<\/em><\/li>\n\n\n\n
  33. Smith, B.K., Perry, C.G.R., Koves, T.R., Wright, D.C., Smith, J.C.<\/strong>, Neufer, P.D., Muoio, D.M., Holloway, G.P. (2012) Identification of a novel malonyl-CoA IC50 for CPT-1: implications for predicting in vivo fatty acid oxidation rates. Biochemical Journal. 448(1):13-20.  PMID: 22928974<\/em><\/li>\n\n\n\n
  34. Lummiss, J.A.M., Beach, N.J., Smith, J.C.<\/strong>, Fogg, D.E. (2012) Targeting an Achilles Heel in Olefin Metathesis: A Strategy for High-Yield Synthesis of Second-Generation Grubbs Methylidene Catalysts. Catalysis Science & Technology. 2:1630-1632.<\/li>\n\n\n\n
  35. Marquez, B.K., Koziol, A.G., Huebsch, M.P., Smith, J.C.<\/strong>, Altosaar, I. (2012) Commercially produced rice and maize starches contain non-host proteins, as shown by mass spectrometry. Cereal Chemistry. 89(5):262-264.<\/li>\n\n\n\n
  36. Jodayree, S., Smith, J.C.<\/strong>, Tsopmo, A. (2012) Use of cell wall polysaccharide degrading enzymes to enhance protein extraction efficiency and antioxidative properties of oat bran protein hydrolysates. Food Research International. 46(1): 69\u201375.<\/li>\n\n\n\n
  37. Koziol, A.G., Marquez, B.K., Huebsch, M.P., Smith, J.C.<\/strong>, Altosaar, I. (2011) The starch granule associated proteomes of commercially purified starch reference materials from rice and maize. The Journal of Proteomics. 75(3):993-1003. PMID: 22062158<\/li>\n\n\n\n
  38. Sinclair, D., Rollin, E., Smith, J.C.<\/strong>, (54 authors), Yen, Y.R. (2011) Prospects for Barium Tagging in Gaseous Xenon. Journal of Physics: Conference Series.  309(1):1-8.<\/li>\n<\/ol>\n\n\n\n

    For further publications, Click here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Published Research Articles For further publications, Click here.<\/p>\n","protected":false},"author":2,"featured_media":743,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_cu_dining_location_slug":"","footnotes":"","_links_to":"","_links_to_target":""},"cu_page_type":[],"class_list":["post-138","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":{"cu_post_thumbnail":""},"_links":{"self":[{"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/pages\/138","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/comments?post=138"}],"version-history":[{"count":4,"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/pages\/138\/revisions"}],"predecessor-version":[{"id":745,"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/pages\/138\/revisions\/745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/media\/743"}],"wp:attachment":[{"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/media?parent=138"}],"wp:term":[{"taxonomy":"cu_page_type","embeddable":true,"href":"https:\/\/carleton.ca\/smithlab\/wp-json\/wp\/v2\/cu_page_type?post=138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}