{"id":1217,"date":"2019-03-23T13:34:56","date_gmt":"2019-03-23T17:34:56","guid":{"rendered":"https:\/\/carleton.ca\/springconference\/?p=1217"},"modified":"2019-03-23T13:57:18","modified_gmt":"2019-03-23T17:57:18","slug":"novel-treatments-for-the-good-of-treating-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/","title":{"rendered":"For the good of treating Parkinson’s Disease: Learn about novel treatments"},"content":{"rendered":"

In Parkinson\u2019s disease, a key neuropathological hallmark is the aggregation of misfolded alpha-synuclein proteins that can lead to toxic outcomes. In the aging brain, accumulation of proteins can set off cell death signals due to a reduction in protective mechanisms.<\/span><\/p>\n

The ability to inhibit protein aggregation during aging would be central in staving off the neurodegenerative process. The current research project asks the question: Can a DNA aptamer targeted to bind to alpha-synuclein monomers inhibit protein aggregation and reduce Parkinson\u2019s\u2013related neurodegeneration?<\/span><\/p>\n

Professor <\/span>Matthew Holohan <\/span><\/a>(Department of Neuroscience) and <\/span>Professor Maria Derosa <\/span><\/a>(Department of Chemistry) are working collaboratively on this project and their presentation, entitled Developments of novel treatments for the good of treating Parkinson’s Disease<\/em>, will speak to their central research question.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

In Parkinson\u2019s disease, a key neuropathological hallmark is the aggregation of misfolded alpha-synuclein proteins that can lead to toxic outcomes. In the aging brain, accumulation of proteins can set off cell death signals due to a reduction in protective mechanisms. The ability to inhibit protein aggregation during aging would be central in staving off the […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","_mi_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"yoast_head":"\nFor the good of treating Parkinson's Disease: Learn about novel treatments - Spring Conference<\/title>\n<meta name=\"description\" content=\"In Parkinson\u2019s disease, a key neuropathological hallmark is the aggregation of misfolded alpha-synuclein proteins that can lead to toxic outcomes. In the\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"marthaattridgebufton\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/\",\"url\":\"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/\",\"name\":\"For the good of treating Parkinson's Disease: Learn about novel treatments - Spring Conference\",\"isPartOf\":{\"@id\":\"https:\/\/carleton.ca\/springconference\/#website\"},\"datePublished\":\"2019-03-23T17:34:56+00:00\",\"dateModified\":\"2019-03-23T17:57:18+00:00\",\"author\":{\"@id\":\"https:\/\/carleton.ca\/springconference\/#\/schema\/person\/fd68d25b3da628edd27b77d832085515\"},\"description\":\"In Parkinson\u2019s disease, a key neuropathological hallmark is the aggregation of misfolded alpha-synuclein proteins that can lead to toxic outcomes. In the\",\"breadcrumb\":{\"@id\":\"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/carleton.ca\/springconference\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"News\",\"item\":\"https:\/\/carleton.ca\/springconference\/category\/news\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"For the good of treating Parkinson’s Disease: Learn about novel treatments\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/carleton.ca\/springconference\/#website\",\"url\":\"https:\/\/carleton.ca\/springconference\/\",\"name\":\"Spring Conference\",\"description\":\"Carleton University\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/carleton.ca\/springconference\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/carleton.ca\/springconference\/#\/schema\/person\/fd68d25b3da628edd27b77d832085515\",\"name\":\"marthaattridgebufton\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/carleton.ca\/springconference\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/11f516c7f325c6e07ac1debd25d09184?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/11f516c7f325c6e07ac1debd25d09184?s=96&d=mm&r=g\",\"caption\":\"marthaattridgebufton\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"For the good of treating Parkinson's Disease: Learn about novel treatments - Spring Conference","description":"In Parkinson\u2019s disease, a key neuropathological hallmark is the aggregation of misfolded alpha-synuclein proteins that can lead to toxic outcomes. In the","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/","twitter_misc":{"Written by":"marthaattridgebufton","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/","url":"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/","name":"For the good of treating Parkinson's Disease: Learn about novel treatments - Spring Conference","isPartOf":{"@id":"https:\/\/carleton.ca\/springconference\/#website"},"datePublished":"2019-03-23T17:34:56+00:00","dateModified":"2019-03-23T17:57:18+00:00","author":{"@id":"https:\/\/carleton.ca\/springconference\/#\/schema\/person\/fd68d25b3da628edd27b77d832085515"},"description":"In Parkinson\u2019s disease, a key neuropathological hallmark is the aggregation of misfolded alpha-synuclein proteins that can lead to toxic outcomes. In the","breadcrumb":{"@id":"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/carleton.ca\/springconference\/"},{"@type":"ListItem","position":2,"name":"News","item":"https:\/\/carleton.ca\/springconference\/category\/news\/"},{"@type":"ListItem","position":3,"name":"For the good of treating Parkinson’s Disease: Learn about novel treatments"}]},{"@type":"WebSite","@id":"https:\/\/carleton.ca\/springconference\/#website","url":"https:\/\/carleton.ca\/springconference\/","name":"Spring Conference","description":"Carleton University","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/carleton.ca\/springconference\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/carleton.ca\/springconference\/#\/schema\/person\/fd68d25b3da628edd27b77d832085515","name":"marthaattridgebufton","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/carleton.ca\/springconference\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/11f516c7f325c6e07ac1debd25d09184?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/11f516c7f325c6e07ac1debd25d09184?s=96&d=mm&r=g","caption":"marthaattridgebufton"}}]}},"acf":{"Post Thumbnail Icon":"","Post Thumbnail":{"ID":1218,"id":1218,"title":"Matthew Holohan and Maria Derosa","filename":"Holohan-and-Derosa-2.png","filesize":240896,"url":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2.png","link":"https:\/\/carleton.ca\/springconference\/2019\/novel-treatments-for-the-good-of-treating-parkinsons-disease\/holohan-and-derosa-2\/","alt":"","author":"7","description":"","caption":"","name":"holohan-and-derosa-2","status":"inherit","uploaded_to":1217,"date":"2019-03-23 17:34:25","modified":"2019-03-23 17:34:39","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/carleton.ca\/springconference\/wp\/wp-includes\/images\/media\/default.png","width":310,"height":278,"sizes":{"thumbnail":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2-160x143.png","thumbnail-width":160,"thumbnail-height":143,"medium":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2-240x215.png","medium-width":240,"medium-height":215,"medium_large":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2.png","medium_large-width":310,"medium_large-height":278,"large":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2.png","large-width":310,"large-height":278,"gallery-thumb":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2-300x230.png","gallery-thumb-width":300,"gallery-thumb-height":230,"1536x1536":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2.png","1536x1536-width":310,"1536x1536-height":278,"2048x2048":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2.png","2048x2048-width":310,"2048x2048-height":278,"banner":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2.png","banner-width":310,"banner-height":278,"people":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2-200x200.png","people-width":200,"people-height":200,"post-thumb":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2-300x230.png","post-thumb-width":300,"post-thumb-height":230,"rotator-image":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2.png","rotator-image-width":310,"rotator-image-height":278,"video-thumb":"https:\/\/carleton.ca\/springconference\/wp-content\/uploads\/Holohan-and-Derosa-2.png","video-thumb-width":310,"video-thumb-height":278}}},"_links":{"self":[{"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/posts\/1217"}],"collection":[{"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/comments?post=1217"}],"version-history":[{"count":2,"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/posts\/1217\/revisions"}],"predecessor-version":[{"id":1226,"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/posts\/1217\/revisions\/1226"}],"wp:attachment":[{"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/media?parent=1217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/categories?post=1217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/carleton.ca\/springconference\/wp-json\/wp\/v2\/tags?post=1217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}