REFEREED PAPERS PUBLISHED OR ACCEPTED
1) Flueraru M, Chichirau A, Chepelev LL, Willmore WG, Durst T, Charron M, Barclay LRC and Wright JS. 2005. Cytotoxicity and cytoprotective activity in naphthalenediols depends on their tendency to form naphthoquinones. Free Radical Biology & Medicine (accepted).
2) Willmore WG and Storey KB. 2005. Purification and characterization of glutathione S-transferase from the slider turtle Trachemys scripta elegans. FEBS Journal 272: 3602-3614.
3) Farha MA and Willmore WG. 2005. Post-translational modification and protein stabilization of erythroid-specific 5-aminolevulinate synthase under hypoxia. Biochemistry and Cell Biology 83:(in press).
4) Chichirau A, Flueraru M, Chepelev LL, Wright JS, Willmore WG, Durst T, Hussain HH and Charron M. 2005. Mechanism of cytotoxicity of catechols and a naphthalenediol in PC-12AC cells: the connection between extracellular autoxidation and molecular electronic structure. Free Radical Biology & Medicine 38: 344-355.
5) Farha MA and Willmore WG. 2004. Hypoxic stabilization and proteolytic degradation of erythroid-specific 5-aminolevulinate synthase. International Congress Series 1275: 71-78.
6) Willmore WG, Cowan KJ and Storey KB. 2001. Effects of anoxia exposure and aerobic recovery on metabolic enzyme activities in the freshwater turtle Trachemys scripta elegans. Canadian Journal of Zoology 79: 1822-1828.
7) Willmore WG, English TE, and Storey KB. 2001. Mitochondrial gene responses to low oxygen stress in turtle organs. Copeia 2001: 628-637.
8) Horiguchi H, Kayama F, Oguma E, Willmore WG, Hradecky P and Bunn HF. 2000. Cadmium and platinum suppression of erythropoietin production in cell culture: clinical implications. Blood 96: 3743-3747.
9) Willmore WG, Huang LE, Gu J, Goldberg, MA and Bunn HF. 1999. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Journal of Biological Chemistry 274(13): 9038-9044.
10) Willmore WG and Storey KB. 1997. Glutathione systems and anoxia tolerance in turtles. American Journal of Physiology 273 (Regulatory, Integrative and Comparative Physiology 42): R219-R225.
11) Willmore WG and Storey KB. 1997. Antioxidant systems and anoxia tolerance in a freshwater turtle Trachemys scripta elegans. Molecular and Cellular Biochemistry 170: 177-185.
12) Willmore WG and Storey KB. 1996. Multicatalytic proteinase activity during anoxia and recovery in the slider turtle Trachemys scripta elegans. Biochemistry and Molecular Biology International 38(3): 445-451.
13) Hermes-Lima M, Willmore WG, and Storey KB. 1995. Quantification of lipid hydroperoxides in tissue extracts based on Fe (III) xylenol orange complex formation. Free Radical Biology & Medicine 19(3): 271-280.
BOOK CHAPTERS PUBLISHED
1) Willmore WG. 2004. Control of Transcription in Eukaryotic Cells. In: Functional Metabolism: Regulation and Adaptation. Kenneth B. Storey (ed). Wiley-Liss, Inc., Hoboken, NJ.
2) Willmore WG. 2004. Translational Controls and Protein Synthesis in Eukaryotic Cells. In: Functional Metabolism: Regulation and Adaptation. Kenneth B. Storey (ed). Wiley-Liss, Inc., Hoboken, NJ.
ABSTRACTS IN REFEREED CONFERENCE PROCEEDINGS
1) Farha MA and Willmore WG. Post-translational modification and protein stabilization of ALAS2 under hypoxia. Canadian Society of Biochemistry, Molecular & Cellular Biology (CSBMCB) 47th Annual Meeting, Mont Tremblant, Quebec, May 27-30, 2004. Biochemistry and Cell Biology 82(6): 755.
2) Willmore WG and Bunn HF. Protection from mixed function oxidation of pyruvate kinase activity by transition metals. 6th Annual Meeting of the Oxygen Society, New Orleans Marriott, New Orleans, Louisiana, November 18-22, 1999. Free Radicals In Biology and Medicine 27(S1): 34.
3) Willmore WG, Gorr TA and Bunn HF. Effects of ROS on hypoxia- and cobalt-induced HIF-1 binding and erythropoietin expression in Hep3B. 6th Annual Meeting of the Oxygen Society, New Orleans Marriott, New Orleans, Louisiana, November 18-22, 1999. Free Radicals In Biology and Medicine 27(S1): 164.
4) Willmore WG and Bunn HF. Role of mitochondria in oxygen sensing. 6th Annual Meeting of the Oxygen Society, New Orleans Marriott, New Orleans, Louisiana, November 18-22, 1999. Free Radicals In Biology and Medicine 27(S1): 190.
ABSTRACTS IN NON-REFEREED CONFERENCE PROCEEDINGS
1) Bielecki A, Husak S and Willmore WG. The role of hypoxia in amyloid precursor protein (APP) expression and Alzheimer’s disease. Second Northern Lights Summer Conference, Canadian Federation of Biological Sciences 48th Annual Meeting, University of Guelph, Guelph, Ontario, June 21-25, 2005.
2) Niles J and Willmore WG. A cost effective alternative to real-time PCR for DNA quantification and analysis of gene expression. Second Northern Lights Summer Conference, Canadian Federation of Biological Sciences 48th Annual Meeting, University of Guelph, Guelph, Ontario, June 21-25, 2005.
3) Farha MA and Willmore WG. Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteosomal inhibition. Second Northern Lights Summer Conference, Canadian Federation of Biological Sciences 48th Annual Meeting, University of Guelph, Guelph, Ontario, June 21-25, 2005.
4) Flueraru M, Chichirau A, Wright JS and Willmore WG. Testing naphthalenediols for toxicity and protective effects in adrenal cells. Ottawa-Carleton Chemistry Institute Day, University of Ottawa, Ottawa, Ontario, June 3, 2005.
5) Bielecki A, Husak S and Willmore WG. The role of hypoxia in amyloid precursor protein (APP) expression and Alzheimer’s disease. BioNorth, 11th Annual Ottawa Life Sciences International Conference & Exhibition, Ottawa Congress Center, Ottawa, Ontario, November 29-December 1, 2004.
6) Niles J, Kavanagh C and Willmore WG. A cost effective alternative to real-time PCR for DNA quantification and analysis of gene expression. BioNorth, 11th Annual Ottawa Life Sciences International Conference & Exhibition, Ottawa Congress Center, Ottawa, Ontario, November 29-December 1, 2004.
7) Farha MA and Willmore WG. Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteosomal inhibition. BioNorth, 11th Annual Ottawa Life Sciences International Conference & Exhibition, Ottawa Congress Center, Ottawa, Ontario, November 29-December 1, 2004.
8) Farha MA and Willmore WG. Post-translational modification and protein stabilization of ALAS2 under hypoxia. The 4th International Conference of the Canadian Proteomics Initiative, International Civil Aviation Organization Building, Montreal, Quebec, May 14-16, 2004.
9) Farha MA and Willmore WG. Lack of hydroxylation stabilizes ALAS2 under hypoxia. BioNorth 2003, 10th Annual Ottawa Life Sciences International Conference & Exhibition, Ottawa Congress Center, Ottawa, Ontario, November 17-19, 2003.
10) Flueraru M, Chichirau A, Wright JS and Willmore WG. Novel synthetic antioxidants as anti-aging compounds. 6th Annual Chemistry and Biochemistry Graduate Research Conference, Concordia University, Montreal, Quebec, November 14-15, 2003.
11) Chichirau A, Flueraru M, Azad MT, Wright JS and Willmore WG. Antioxidant or prooxidant? Cell toxicity of novel catechols. 6th Annual Chemistry and Biochemistry Graduate Research Conference, Concordia University, Montreal, Quebec, November 14-15, 2003.
12) McDonnell L, Andersson S, Sundberg B, Willmore WG, Glick B and Regan S. Are ethylene levels tightly regulated in vascular tissues? Functional analysis of a plant-encoded ACC deaminase. Tree Biotechnology, Umea, Sweden, 2003.
13) Wright JS, Flueraru M, Chichirau A, Chepelev L, Willmore WG, Miller JD, Poulter MO, DeButte M, Pappas B, Durst T, Babic G, Hussain HH, Barclay LRC and Ingold KU. Novel synthetic antioxidants as age-retarding compounds: Design strategy, synthesis and testing in chemical systems and cell cultures. 39th IUPAC Congress and 86th Conference of the Canadian Society for Chemistry, Ottawa University, Ottawa, Ontario, August 10-15, 2003.
14) Willmore WG, Zhu H, Huang S, Robbins J and Bunn HF. Regulation of oxygen-dependent transcription by iron-mediated mixed function oxidase inactivation of HIF-1 DNA binding. American Society for Biochemistry and Molecular Biology & the American Society for Pharmacology and Experimental Therapeutics Joint Meeting, Hynes Convention Center, Sheraton Boston Hotel, Boston, Massachusetts, June 4-8, 2000.
15) Willmore WG. Regulation of oxygen-dependent transcription by iron-mediated mixed function oxidase in activation of HIF-1 DNA binding. Hematology/Genetics Division Seminar Series, Carrie Hall Conference Room, Brigham and Women’s Hospital, Boston, Massachusetts, May 18, 2000.
16) Willmore WG, Zhu H, Huang S, Robbins J and Bunn HF. Iron-dependent mixed function oxidase inactivation of hypoxia inducible factor-1 DNA binding. “PAS Proteins: Sensors of Environmental and Developmental Signals”, National Institute of Environmental Health Sciences, Rodbell Auditorium, Research Triangle Park, North Carolina, April 16-18, 2000.
17) Willmore WG and Bunn HF. Role of mitochondria in oxygen sensing. “Oxygen Sensing: Molecule to Man” XIV International Symposium on Arterial Chemoreception, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, June 24-28, 1999.
18) Willmore WG and Bunn HF. Role of mitochondria in oxygen sensing. Hematology Poster Session, Hematology Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts, May 19, 1999.
19) Willmore WG, Goldberg MA and Bunn HF. Effect of carbon monoxide on oxygen sensing: HIF-1 binding and erythropoeitin gene expression. International Conference on Oxygen Binding and Oxygen Activating/Sensing Heme Proteins, Pacific Grove, California, September 27-October 2, 1998.
20) Willmore WG, Cowan KJ and Storey KB. Changes in metabolic flux potential during anoxia and recovery in the anoxia tolerant turtle Trachemys scripta elegans. Canadian Federation of Biological Societies 39th Annual Meeting, London, Ontario, June 19-22, 1996.
21) Hermes-Lima M, Willmore WG and Storey KB. Lipid peroxidation determination in animal tissue extracts based on Fe (III)-xylenol orange complex formation. Federation of Societies of Experimental Biology 10th Annual Meeting, Serra Negra, Brazil, August 23-26, 1995.
INVITED PRESENTATIONS
1) Adaptive responses to low oxygen. Third International Conference of Comparative Physiology & Biochemistry in Africa: Animals and Environments, Ithala Game Reserve, KwaZulu-Natal, South Africa, August 7-13, 2004
2) The oxygen paradox: life at oxygen extremes. Carleton University Spring Conference, Opinicon Lodge, Chaffey’s Lock, May 1, 2004.
3) Adaptive response to oxygen stress: nonspecific and specific modification of protein structure and function by oxygen. The 42nd Annual Meeting of the Canadian Society of Zoologists (CSZ). Comparative Physiology and Biochemistry. Metabolic Plasticity in Animal Adaptations. Wilfrid Laurier University, Kitchener/Waterloo. May 10, 2003.
4) Adaptive response to oxygen stress: nonspecific and specific modification of protein structure and function by oxygen. Ottawa Carleton Chemistry Institute. Ottawa. May 6, 2003.
5) Protein regulation by oxygen: a tale of two extremes. Department of Biology, Queen’s University. Kingston. February 11, 2003.
6) Oxygen: a two-edged sword. Oxygen control of Hypoxia-Inducible Factor-1 (HIF-1) structure and function. Department of Biology. University of Ottawa. Ottawa. November 21, 2002.
7) Oxygen: a two-edged sword. Oxygen regulation of protein structure/function and gene expression. Department of Biochemistry, Microbiology, and Immunology, University of Ottawa. Ottawa. October 24, 2002.
8) Oxygen: a double-edged sword. Oxygen effects on protein structure and function. National Wildlife Research Council. Ottawa. April 17, 2002.