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Publications

Published Research Articles

  1. Menard, J.A., Roberts, J.A., Clarke, J.H., Rudd, K.E.A., Rosales, C.A., Smith, J.C. (2026) LC-MS FADE: Leveraging Untargeted Lipidomics Data for Fatty Acid Profiling. 98(28):20789–20800. doi: 10.1021/acs.analchem.6c01325.
  2. Menard, J.A., Zinnecker, T., Godbout, E., Roberts, J.A., Arulanandam, R., Chen, A., Landry, A., Boddy, C.N., Reichl, U., Diallo, J.-S., Genzel, Y., Smith, J.C. (2026) Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection. 16:882. doi: 10.1038/s41598-025-33499-1.
  3. Rosales, C.A., Lepinsky, N.A., Ramadan, M., Manthorpe, J.M., Jonz, M.G., Smith, J.C. (2025) Enhanced LC-MS Detection of γ-Aminobutyric Acid via Trimethylation Enhancement Using Diazomethane. 36(12):2699–2706. doi: 10.1021/jasms.5c00294.
  4. Fulton, K.M., Mendoza-Barberà, E., Tomás, J.M., Twine, S.M., Smith, J.C., Merino, S. (2025) Polar flagellin glycan heterogeneity of Aeromonas hydrophila strain ATCC 7966T. 158:108300. doi: 10.1016/j.bioorg.2025.108300.
  5. Rosales, C.A., Lepinsky, N.A., Gebeyehu, W., Wasslen, K.V., Colquhoun, F., Warnes, B.B., Chihabi, J., Manthorpe, J.M., Smith, J.C. (2025) Improved LC-MS Detection of Opioids, Amphetamines, and Psychedelics Using TrEnDi. 36(3):514–523. doi: 10.1021/jasms.4c00382.
  6. Roberts, J.A., Radnoff, A.S., Bushueva, A., Menard, J.A., Wasslen, K.V., Harley, M., Manthorpe, J.M., Smith, J.C. (2024) Mobile Phase Contaminants Affect Neutral Lipid Analysis in LC-MS-Based Lipidomics Studies. 35(12):3095–3106. doi: 10.1021/jasms.4c00320.
  7. Shields, S.W.J., Canez, C.R., Rosales, C.A., Roberts, J.A., Bourgaize, H., Pallister, P.J., Manthorpe, J.M., Smith, J.C. (2024) Optimized 13C TrEnDi Enhances the Sensitivity of Plasmenyl Ether Glycerophospholipids and Demonstrates Compatibility with Other Derivatization Strategies. 35(5):972–981. doi: 10.1021/jasms.4c00015.
  8. Roberts, J.A., Godbout, E., Menard, J.A., Boddy, C.N., Diallo, J.-S., Smith, J.C. (2024) Comprehensive untargeted lipidomic profiling of third generation lentiviral vectors and packaging cells. 20(10):642–653. doi: 10.1039/d4mo00052h.
  9. Rosales, C.A., Sheedy, K.L., Wasslen, K.V., Manthorpe, J.M., Smith, J.C. (2024) Trimethylation Enhancement Using Diazomethane (TrEnDi) Enables Enhanced Detection of Glufosinate and 3-(Methylphosphinico)propionic Acid from Complex Canola Samples. 35(1):140–150. doi: 10.1021/jasms.3c00376.
  10. Roberts, J.A., Rosales, C.A., Wasslen, K.V., Radnoff, A.S., Godbout, E., Diallo, J.-S., Manthorpe, J.M., Smith, J.C. (2023) An In Silico Database for Automated Feature Identification of High-Resolution Tandem Mass Spectrometry 13C-Trimethylation Enhancement Using Diazomethane (13C TrEnDi)-Modified Lipid Data. 34(12):2722–2730. doi: 10.1021/jasms.3c00273.
  11. Rosales, C.A., Shields, S.W.J., Aulenback, C.L.J., Elezi, G., Wasslen, K.V., Pallister, P.J., Faull, K.F., Manthorpe, J.M., Smith, J.C. (2023) Improved Chromatography and MS-Based Detection of Glyphosate and Aminomethylphosphonic Acid Using iTrEnDi. 34(5):948–957. doi: 10.1021/jasms.3c00026.
  12. Country, M.W., Haase, K., Blank, K., Canez, C.R., Roberts, J.A., Campbell, B.F.N., Smith, J.C., Pelling, A.E., Jonz, M.G. (2022) Seasonal changes in membrane structure and excitability in retinal neurons of goldfish (Carassius auratus) under constant environmental conditions. 225(10):jeb244238. doi: 10.1242/jeb.244238.
  13. Forn-Cuní, G., Fulton, K.M., Smith, J.C., Twine, S.M., Mendoza-Barberà, E., Tomás, J.M., Merino, S. (2021) Polar Flagella Glycosylation in Aeromonas: Genomic Characterization and Involvement of a Specific Glycosyltransferase (Fgi-1) in Heterogeneous Flagella Glycosylation. 11:595697. doi: 10.3389/fmicb.2020.595697.
  14. Shields, S.W.J., Rosales, C.A., Roberts, J.A., Pallister, P.J., Wasslen, K.V., Manthorpe, J.M., Smith, J.C. (2021) iTrEnDi: In Situ Trimethylation Enhancement Using Diazomethane: Improved and Expanded Glycerophospholipid and Sphingolipid Analyses via a Microscale Autonomous Derivatization Platform. 93(2):1084–1091. doi: 10.1021/acs.analchem.0c04088.
  15. Franklin, E.T., Shields, S.W.J., Manthorpe, J.M., Smith, J.C., Xia, Y., McLuckey, S.A. (2020) Coupling Headgroup and Alkene Specific Solution Modifications with Gas-Phase Ion/Ion Reactions for Sensitive Glycerophospholipid Identification and Characterization. 31(4):938–945. doi: 10.1021/jasms.0c00001.
  16. Jonz, M., Country, M., Blank, K. (2020) Action Potential Activity and Membrane Structure in Neurons of the Goldfish Retina Undergo Seasonal Changes. 118:457a.
  17. Black, C., D’Souza, T., Smith, J.C., Hearns, N.G.R. (2019) Identification of post-blast explosive residues using direct-analysis-in-real-time and mass spectrometry (DART-MS). 16:100185. doi: 10.1016/j.forc.2019.100185.
  18. Fulton, K.M., Li, J., Tomas, J.M., Smith, J.C., Twine, S.M. (2018) Characterizing bacterial glycoproteins with LC-MS. 15(3):203–216. doi: 10.1080/14789450.2018.1435276.
  19. Betancourt, S., Canez, C., Shields, S., Manthorpe, J., Smith, J.C., McLuckey, S.  (2017) Trimethylation Enhancement Using 13C Diazomethane (13C-TrEnDi):  Gas-Phase Charge Inversion of Modified Phospholipid Cations for Enhanced Structural Characterization. 89(17):9452–9458. doi: 10.1021/acs.analchem.7b02271
  20. Tessier, S.N., Luu, B.E., Smith, J.C., Storey, K.B. (2017) The role of global histone post-translational modifications during mammalian hibernation. 75: 28-36.  doi: 10.1016/j.cryobiol.2017.02.008
  21. Fulton, K.M., Smith, J.C., Twine, S.M.  (2016) Clinical Applications of Bacterial Glycoproteins.  Expert Review of Proteomics.  13(4):345-53. doi: 10.1586/14789450.2016.1166054.
  22. Canez, C.R., Shields, S.W.J., Bugno, M., Wasslen, K.V., Willmore, W.G., Manthorpe, J.M., Smith, J.C. (2016) Trimethylation enhancement using 13C-diazomethane (13C-TrEnDi): Increased sensitivity and selectivity of phosphatidylethanolamine, phosphatidylcholine and phosphatidylserine lipids derived from complex biological samples. Analytical Chemistry. Jul 19;88(14):6996-7004. doi: 10.1021/acs.analchem.5b04524.
  23. Dornan, M.H., Krishnan, R., Macklin, A.M., Selman, M., El Sayes, N., Hee Son, H., Davis, C., Chen, A., Keillor, K., Le, P., Moi, C., Ou, P., Pardin, C., Canez, C.R., Le Boeuf, F., Bell, J.C., Smith, J.C.,* Diallo, J-S.,* Boddy, C.N.* (2016) First-in-class small molecule potentiators of cancer virotherapy. Nature Scientific Reports.  May 26;6:26786. doi: 10.1038/srep26786. PMID: 27226390. (* – co-corresponding authorship).
  24. Farmer, K., Smith, C., Hayley, S., Smith, J.C. (2015) Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease.  International journal of molecular sciences. Aug 12;16(8): 18865-18877. PMID: 26274953.
  25. Smith, C., Farmer, K., Lee, H., Hollohan, M., Smith, J.C. (2015) Altered hippocampal lipid profile following acute postnatal exposure to di(2-ethylhexyl) phthalate in rats. International journal of environmental research and public health.  Oct 27;12(10): 13542-13559.  PMID: 26516880.
  26. Bell, R., Smith, J.C., Storey, K.B. (2014) Purification and properties of glyceraldehyde-3-phosphate dehydrogenase from the skeletal muscle of the hibernating ground squirrel, Ictidomys tridecemlineatus.  Oct 28;2:e634. doi: 10.7717/peerj.634. eCollection 2014. PMID: 25374779.
  27. Wasslen, K.V., Canez, C.R., Lee, H., Manthorpe, J.M., Smith, J.C. (2014) Trimethylation Enhancement using Diazomethane (TrEnDi) II: Rapid In-Solution Concomitant Quaternization of Glycerophospholipid Amino Groups and Methylation of Phosphate Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge. Analytical Chemistry. Oct 7;86(19): 9523-9532. DOI: 10.1021/ac501588y. PMID: 25208053.
  28. Wasslen, K.V., Tan, L.H., Manthorpe, J.M., Smith, J.C. (2014) Trimethylation Enhancement using Diazomethane (TrEnDi): Rapid On-Column Quaternization of Peptide Amino Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge. Analytical Chemistry.  Apr 1;86(7):3291-9. doi:10.1021/ac403349c. PMID: 24555738.
  29. Chao, S., Green, J.R., Smith, J.C. (2014) Evaluation of a GPGPU-based de novo peptide sequencing algorithm. Journal of Medical and Biological Engineering. Jan 1; 34(5): 461-468. doi:10.5405/jmbe.1713.
  30. Wasslen, K., Wood, S., Manthorpe, J., Smith, J.C. (2013) Trimethylation enhancement using diazomethane (TrEnDi): Rapid on-column methylation of peptides and proteins to permit quantitative analysis using tandem mass spectrometry.  Rapid Communications in Mass Spectrometry.  27(22):2576.   Extended abstract from the 7th International Symposium on Enabling Technologies at the Metro Toronto Convention Centre, Toronto, ON on April 30th, 2013.
  31. Smith, B.K., Perry, C.G.R., Herbst, E.A., Ritchie, I.R., Beaudoin, M-S., Smith, J.C., Neufer, P.D., Wright, D.C., Holloway, G.P. (2013)  Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol.  Journal of Physiology. 591(Pt 23):6089-6101.  PMID: 24081154
  32. Frahm, G.E., Eastwood, G., Cameron, B.E., Smith, J.C., Johnston, M.J.W. (2013) Generation of fatty acids from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/cardiolipin liposomes that stabilize recombinant human serum albumin. Journal of Liposome Research.  23(2):101-109. PMID: 23294393.
  33. Smith, B.K., Perry, C.G.R., Koves, T.R., Wright, D.C., Smith, J.C., Neufer, P.D., Muoio, D.M., Holloway, G.P. (2012) Identification of a novel malonyl-CoA IC50 for CPT-1: implications for predicting in vivo fatty acid oxidation rates. Biochemical Journal. 448(1):13-20.  PMID: 22928974
  34. Lummiss, J.A.M., Beach, N.J., Smith, J.C., Fogg, D.E. (2012) Targeting an Achilles Heel in Olefin Metathesis: A Strategy for High-Yield Synthesis of Second-Generation Grubbs Methylidene Catalysts. Catalysis Science & Technology. 2:1630-1632.
  35. Marquez, B.K., Koziol, A.G., Huebsch, M.P., Smith, J.C., Altosaar, I. (2012) Commercially produced rice and maize starches contain non-host proteins, as shown by mass spectrometry. Cereal Chemistry. 89(5):262-264.
  36. Jodayree, S., Smith, J.C., Tsopmo, A. (2012) Use of cell wall polysaccharide degrading enzymes to enhance protein extraction efficiency and antioxidative properties of oat bran protein hydrolysates. Food Research International. 46(1): 69–75.
  37. Koziol, A.G., Marquez, B.K., Huebsch, M.P., Smith, J.C., Altosaar, I. (2011) The starch granule associated proteomes of commercially purified starch reference materials from rice and maize. The Journal of Proteomics. 75(3):993-1003. PMID: 22062158
  38. Sinclair, D., Rollin, E., Smith, J.C., (54 authors), Yen, Y.R. (2011) Prospects for Barium Tagging in Gaseous Xenon. Journal of Physics: Conference Series.  309(1):1-8.

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