Check out the Maria’s Google Scholar page for the latest information about the DeRosa lab publications.

Patent Applications

APTAMERS AS A THERAPEUTIC TOOL TO PREVENT PROTEIN AGGREGATION IN NEURODEGENERATIVE DISEASE DEROSA, Maria Cynthia; HOLAHAN, Matthew Richard; MCCONNELL, Erin Marie; VENTURA, Katelyn Victoria; CALLAHAN, Joshua Parker; HUNT, Vernon Harold Daniel US Patent Application 62/575,813

Publication list 2009-2017

63) A. Ruscito, E. M. McConnell, A. Koudrina, R. Velu, C. Mattice, V. Hunt, M. McKeague*, and M. C. DeRosa* “In Vitro Selection and Characterization of DNA Aptamers to a Small Molecule Target” Current Protocols in Chemical Biology, 2017, 9, 1–36. in press

62) E. Mastronardi, C. Monreal, M. C. DeRosa* “Personalized medicine for crops? Opportunities for the application of molecular recognition in agriculture” J. Agri. Food. Chem 2017, DOI: 10.1021/acs.jafc.7b03295

Abstract Image

61) E. M. Hassan, W. Willmore, M. C. DeRosa* “In vitro selections of mammaglobin A and mammaglobin B aptamers for the recognition of circulating breast tumor cells” Sci. Rep 2017,doi:10.1038/s41598-017-13751-z

Figure 1

60) M. McKeague, R. Velu, A. De Girolamo, S. Valenzano, M. Pascale, M.K. Smith, M. C. DeRosa* “Comparison of In-Solution Biorecognition Properties of Aptamers against Ochratoxin A” Toxins 2017 8, 336-340.

59) E. M. Hassan, W.G. Willmore, M.C. DeRosa* “Aptamers: Promising Tools for the Detection of Circulating Tumor Cells” Nucl. Acid. Ther. 2016, 26, 335-347.

58) E.M. McConnell, R. Bolzon, M. C. DeRosa* “pHAST (pH-driven Aptamer Switch for Thrombin) catch-and-release of target protein” Bioconj. Chem., 2016, 27, 1493-1499.

Abstract Image

57) S. Valenzano*, A. De Girolamo*, M. C. De Rosa*, M. McKeague, R. Schena, M. Pascale “Screening and identification of DNA aptamers to tyramine using in vitro selection and high-throughput sequencing” ACS Comb. Sci. 2016, 18, 302-313. (Cover)

Journal Cover

56) A. Ruscito, M .C. DeRosa* “Small-Molecule Binding Aptamers: Selection Strategies, Characterization, and Applications” Front. Chem. 2016, 4, 14. (Invited, Special Issue)

55) A. Ruscito, M. Smith, D. Goudreau, M. C. DeRosa* “Current status and future prospects of aptamer-based mycotoxin detection” J. A. O. A. C. Int. 2016, 99, 865-877.

54) E. Mastronardi, P. K. Tsae, X. Zhang, A. Foster, Y. Sultan, M. C. DeRosa* “Preparation and Characterization of Aptamer-Polyelectrolyte Films and Microcapsules for Biosensing and Delivery Applications.” Methods 2016, 97, 75–87. (Invited, Special Issue).

53) F. Costantini, C. Sberna, G. Petrucci, M. Reverberi, F. Domenici, C. Fanelli, C. Manetti, G. de Cesare, M. C. DeRosa, A. Nascetti, D. Caputo, “Aptamer-based sandwich assay for on chip detection of Ochratoxin A by an array of amorphous silicon photosensors” Sens. Act. B: Chem. 2016, 230, 31-39.

52) M. McKeague, E. M. McConnell, J. Cruz-Toledo, E. Bernard, A. Foster, E. Mastronardi, X. Zhang, M. Beking, T. Francis, A. Giamberardino, A. Cabecinha, A. Ruscito, R. Aranda-Rodriguez, M. Dumontier*, M. C. DeRosa* “Analysis of In Vitro Aptamer Selection Parameters.” J. Mol. Evol. 2015, 81, 150-161. (Invited, Special Issue)

51) C. M. Monreal, M. C. DeRosa, S. C. Mallubhotla, P. S. Bindraban, C. Dimkpa “Nanotechnologies for increasing the crop use efficiency of fertilizer- micronutrients” Biol. Fert. Soils. 2015, 1-15.

50) G. Luka, A. Ahmadi, H. Najjaran, E. Alocilja, M. C. DeRosa, K. Wolthers, A. Malki, H. Aziz, A. Althani, M. Hoorfar “Microfluidics integrated biosensors: A leading technology towards lab-on-a-chip and sensing applications” Sensors 2015, 15, 30011-30031.

49) N. R. Frost, M. McKeague, D. Falcioni, M. C. DeRosa* “An in solution assay for interrogation of affinity and rational minimer design for small molecule-binding aptamers.” Analyst, 2015, 140, 6643-6651.

Graphical abstract: An in solution assay for interrogation of affinity and rational minimer design for small molecule-binding aptamers

48) M. McKeague, A. De Girolamo, S. Valenzano, M. Pascale, A. Ruscito, R. Velu, N. R Frost, K. Hill, M. Smith, E. M. McConnell, M. C. DeRosa* “Comprehensive Analytical Comparison of Strategies Used for Small Molecule Aptamer Evaluation.” Anal. Chem. 2015, 87, 8606-8612. (Chosen for ACS Editor’s Choice)

Abstract Image

47) R. Velu, N. Frost, M. C. DeRosa* “Linkage Inversion Assembled Nano-Aptasensors (LIANAs) for Turn-On Fluorescence Detection” Chem. Comm. 2015, 51, 14346-14349.

Graphical abstract: Linkage inversion assembled nano-aptasensors (LIANAs) for turn-on fluorescence detection

46) C. Mattice, M. C. DeRosa* “Status and Prospects of Aptamers as Drug Components” BioDrugs, 2015, 29, 151-165 (Invited review)

45) P. Tsae, M. C. DeRosa* “Outlook for Aptamers After Twenty Five Years” Curr. Top. Med. Chem. 2015, 15, 1153-1159. (Invited review).

44) R. Walsh, U. Ho, X.-L. Wang, M. C. DeRosa* “Selective Dopamine Detection Using Aptamer-Functionalized Glassy Carbon Electrodes” Can. J. Chem. 2015, 93, 572-577.

43) R. H. Griffin, E. M. McConnell, M. C. DeRosa*, N. G. Tarr* “MOS Testbed for the characterization of Targeted Alpha Therapy Pharmaceuticals.” IEEE Sensors Journal 2015, 15, 1690-1696. (cover)

42) E. B. Bernard, K. C. Nguyen, M. C. DeRosa, A. F. Tayabali, R. Aranda-Rodriguez “Development of a Bead-Based Aptamer/Antibody Detection System for C-Reactive Protein. Anal. Biochem. 2015, 472, 67-74.

41) E. M. McConnell, M. R. Holahan, M. C. DeRosa “Opportunities and Limitations for Aptamers in the Central Nervous System” Nucl. Acids Ther. 2014 24, 388-404. (Invited Review).

40) M. McKeague and M.C. DeRosa “Aptamers and SELEX: Tools for the Development of Transformative Molecular Recognition Technology” Aptamers and Synthetic Antibodies 2014 1, 12-16. (Invited review)

39) M. McKeague, V. Ranganathan, K. Hill, V. Bardozy, T. Mezaros, M. C. DeRosa “Selection and characterization of novel DNA aptamers for label-free fluorescence biosensing of ochratoxin A” Toxins 2014 6, 2435-2452.

38) A. Foster, M.C. DeRosa. “Development of a Biocompatible Layer-by-Layer Film System using Aptamer Technology for Smart Material Applications” Polymers 2014 6, 1631-1654.

37) E. Mastronardi, A. Foster, X. Zhang, M. C. DeRosa “Smart materials based on DNA aptamers: Taking aptasensing to the next level.” Sensors 2014 14, 3156-3171. (Invited Review)

36) F. Matus, C. Monreal, M. Lefebvre, S-S. Wu, R. Desjardins, M. C. DeRosa “Producing Isotopically Enriched Plant, Soil Solution and Rhizosphere Soil Materials Over a Few Hours” Comm. Soil Sci Plant Anal. 2014, 45, 865-880.

35) R. H. Griffin, O. Mozenson, M.A. Beking, M. C. DeRosa, G. Lopinski, N.G. Tarr “Quantitative radiolabeled biomolecule detection using a functionalized CMOS sensor” IEEE Trans. Nucl. Sci., 2014, 61, 1112-1117.

34) S. Smiley, M. C. DeRosa, B. Blais “Immobilization of DNA Aptamers on Polyester Cloth for Antigen Detection by Dot Blot Immunoenzymatic Assay (Aptablot)” J. Nucleic Acids 2013, 2013¸963542.

33) X. Zhang, D. Chabot, Y. Sultan, C. Monreal, M. C. De Rosa “Target-molecule-triggered rupture of aptamer-encapsulated polyelectrolyte microcapsules.” ACS Appl. Mater. Interfaces 2013, 5, 5500-5507.

32) A. Giamberardino, M. Labib, E. Hassan, J. A. Tetro, S. Springthorpe, S. A. Sattar, M. V. Berezovski and M. C. DeRosa “Ultrasensitive Norovirus Detection using DNA Aptasensor Technology.” PLoS One, 2013, 8, e79087.

31) M. McKeague, A. Foster, Y. Miguel, A. Giamberardino, C. Verdin, J.Y.S. Chan, M.C. DeRosa “Development of nucleic acid probes for direct and selective homocysteine detection in human serum” RSC Advances 2013, 3i, 24415-24422.

30) J. Albert, S. Lepinay, C. Caucheteur, M. C. DeRosa “High resolution grating-assisted surface Plasmon resonance fiber optic biosensor” Methods 2013, 63, 239-254.

29) M. McKeague and M. C. DeRosa, “Challenges and Opportunities for Small Molecule Aptamer Development,” J. Nucleic Acids, 2012, 2012,748913. (invited review).

28) Bernard, E. D., Beking, M. A., Rajamanickam, K., Tsai, E. C. and M. C. DeRosa “Target binding improves relaxivity in aptamer-gadolinium conjugates.” J. Biol. Inorg. Chem 2012, 17, 1159-1175.

27) J. Cruz-Toledo,M. McKeague, X. Zhang, A. Giamberardino, E. McConnell, T. Francis, M. C. DeRosa, and M. Dumontier “Aptamer base: a collaborative knowledge base to describe aptamers and SELEX experiments” Database 2012, bas006.

26) B. Xi, I. P. Liu, G. L. Xu, M. M. Choudhuri, M. C. DeRosa, R. J. Crutchley, T. Ren “Modulation of Electronic Couplings within Ru2–Polyyne Frameworks” J. Am. Chem. Soc. 2011, 133, 15094–15104.

25) Y. Shevchenko, T. J. Francis, D. A. Blair, R. Walsh, M. C. DeRosa, J. Albert “In situ biosensing with a surface plasmon resonance fiber grating aptasensor” Anal. Chem. 2011, 83, 7027-7034.

24) M. R. Holahan*, D. Madularu, E. M. McConnell, R. Walsh, M. C. DeRosa* “Intra-accumbens injection of a dopamine aptamer abates MK-801-induced cognitive dysfunction in a model of schizophrenia” PLoS ONE 2011, 6, e22239.

23) Y. Sultan and M. C. DeRosa* “Target Binding influences permeability in aptamer-polyelectrolyte microcapsules” Small 2011, 7, 1219-1226.

22) A. De Girolamo*, M. McKeague, J.D. Miller, M.C. DeRosa, A. Visconti* “Determination of ochratoxin A in wheat after clean-up through a DNA aptamer-based solid phase extraction column” Food Chem. 2011, 127, 1378–1384.

21) M. McKeague, C. R. Bradley, A. DeGirolamo, A. Visconti, J. David Miller, M. C. DeRosa* “Screening and Initial Binding Assessment of Fumonisin B1 Aptamers” Int. J. Mol. Sci. 2010, 11, 4864-4881. (invited)

20) X.-M. Luo, M. McKeague, S. Pitre, M. Dumontier, J. Green, A. Golshani, M. C. DeRosa*, F. Dehne* “Computational Approaches Towards the Design of Pools for the In Vitro Selection Of Complex Aptamers” RNA 2010, 16, 2252-2262. Highlighted by the Faculty of 1000

19) M. C. DeRosa *, C. Monreal, M. Schnitzer, R. Walsh, Y. Sultan “Prospects for Nanotechnology in Fertilizers” Nature Nano. 2010, 5, 91. Highlighted by the Chemical and Engineering News

18) J. A. Lee, M.C. DeRosa* “A pH-driven DNA switch based on the A+•G mispair” Chem. Commun. 2010, 46, 418 – 420.

17) R. Walsh, M. C. DeRosa* “Retention of Function in the DNA homolog of the RNA aptamer” Biochem. Biophys. Res. Commun. 2009, 388, 732-735.

16) Y. Sultan, R. Walsh, C. Monreal, M.C. DeRosa* “Preparation of Functional Aptamer Films by Layer-by-Layer Self-Assembly” Biomacromolecules 2009, 10, 1149-1154.