Past Event! Note: this event has already taken place.
Enterotypes, Autism, Aliens and the Elderly: The microbiome composition is a common thread
May 4, 2017 at 3:00 PM
| Location: | 3220 Richcraft Hall |
| Audience: | Anyone |
| Key Contact: | Paul Villeneuve |
| Contact Email: | Paul.villeneuve@carleton.ca |
Candidate: Dr. Greg Gloor
Professor, Department of Biochemistry
Schulich School of Medicine and Dentistry, The University of Western Ontario
Enterotypes, Autism, Aliens and the Elderly: The microbiome composition is a common thread
The reasons for poor reproducibility of microbiome studies are many and varied, but one key reason is the mismatch between the underlying data and the assumptions made by the common analytic tools. I will use examples drawn from the microbiome literature to demonstrate the nature of the problems and the data analysis pathologies that arise. I will next give a short introduction showing how and why data collected by high throughput sequencing are compositional data, and highlight the rationale behind analysis tools that follow a compositional data analysis approach. The methods will be demonstrated on a very large cohort examining the gut microbiome over the healthy human lifespan. I will finish with my vision for the future of the analysis of these and other sparse, high dimensional datasets.