Publications from Independent Career:

29. Christian Rosales, Samuel Shields, Chelsey Aulenback, Elezi Gazmend, Karl Wasslen, Peter Pallister, Kym Faull, Jeffrey M. Manthorpe, Jeffrey C. Smith
“Improved chromatography and MS-based detection of glyphosate and aminomethylphosphonic acid using iTrEnDi”
Submitted, August 5, 2022

28. Volodymyr Semeniuchenko, Sepideh Sharif, Jonathan Day, Nalin Chandrasoma, William J. Pietro, Jeffrey M. Manthorpe, Wilfried M. Braje, Michael G. Organ
“(DiMeIHeptCl)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination”
Journal of Organic Chemistry, 2021, 86, 10343-10359 LINK

27. Mathieu A. Morin, Debasis Mallik, Wenyao Zhang, William Pietro, Jeffrey M. Manthorpe, Michael G. Organ
“Obtaining Kinetics from Continuous Processes: Sampling Multiple Time Point Concurrently With a Single Valve Rotation
Chemistry—Methods (Open Access), 2021, 1, 131 LINK

26. Monica A. Gill, Samuel W. J. Shields, Jeffrey M. Manthorpe
“Origin of Protonation Side Products in Pd-Catalyzed Decarboxylative Allylation Reactions: Evidence for In Situ Modification of Triphenylphosphine Ligand”
ChemRxiv, Feb 2021 LINK

25. Samuel W. J. Shields, Christian A. Rosales, Joshua A. Roberts, Peter Pallister, Karl V. Wasslen, Jeffrey M. Manthorpe, and Jeffrey C. Smith
“iTrEnDi: In Situ Trimethylation Enhancement Using Diazomethane: Improved and Expanded Glycerophospholipid and Sphingolipid Analyses via a Microscale Autonomous Derivatization Platform”
Analytical Chemistry, 2021, 93, 1084-1091. LINK

24. Elissia T. Franklin, Samuel W. J. Shields, Jeffrey M. Manthorpe, Jeffrey C. Smith, Yu Xia, and Scott A. McLuckey
“Coupling Headgroup and Alkene Specific Solution Modifications with Gas-Phase Ion/Ion Reactions for Sensitive Glycerophospholipid Identification and Characterization”
Journal of the American Society for Mass Spectrometry, 2020, 31, 938-945. LINK

23. Monica A. Gill and Jeffrey M. Manthorpe
“Development of Palladium-Catalyzed Decarboxylative Allylation of Electron-Deficient Sulfones and Identification of Unusual Side Products”
Journal of Organic Chemistry, 2019, 84, 6028-6039. LINK

22. Samuel W. J. Shields, Peter H. Buist, and Jeffrey M. Manthorpe*
“Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R,10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium-Sulfoxide Exchange”
SynOpen (Open Access), 2018, 2, 168-175. LINK

21. Stella K. Betancourt, Carlos R. Canez, Samuel W. J. Shields, Jeffrey M. Manthorpe, Jeffrey C. Smith, and Scott A. McLuckey*
Trimethylation Enhancement using 13C-Diazomethane (13C-TrEnDi): Gas-Phase Charge Inversion of Modified Phospholipid Cations for Enhanced Structural Characterization”
Analytical Chemistry 2017, 89, 9452-9458. LINK

20. Carlos R. Canez, Samuel W. J. Shields, Magdalena Bugno, Karl V. Wasseln, Hillary P. Weinert, William G. Willmore, Jeffrey M. Manthorpe*, and Jeffrey C. Smith*
“Trimethylation Enhancement using 13C-Diazomethane (13C-TrEnDi): Increased Sensitivity and Selectivity of Phosphatidylethanolamine, Phosphatidylcholine and Phosphatidylserine Lipids Derived from Complex Biological Samples”
Analytical Chemistry 2016, 88, 6996-7004. LINK

19. Noof A. Alenazi, Jeffrey M. Manthorpe, Edward P. C. Lai*
“Selectivity Enhancement in Molecularly Imprinted Polymers for Chemical Sensing of Bisphenol A”
Sensors (Open Access) 2016, 16, 1697 (12 pages). (Invited contribution to thematic issue on Molecular Imprinting for Transducers and Applications). LINK

18. Noof A. Alenazi, Jeffrey M. Manthorpe, and Edward P. C. Lai*
“Selective Extraction of BPA in Milk Analysis by Capillary Electrophoresis using a Chemically Modified Molecularly Imprinted Polymer”
Food Control 2015, 50, 778-783. LINK

17. Karl V. Wasslen, Carlos R. Canez, Hyunmin Lee, Jeffrey M. Manthorpe*, and Jeffrey C. Smith*
“Trimethylation Enhancement using Diazomethane (TrEnDi) II: Rapid In-Solution Concomitant Quaternization of Glycerophospholipid Amino Groups and Methylation of Phosphate Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge”
Analytical Chemistry 2014, 86, 9523-9532. LINK

16. Samuel W. J. Shields and Jeffrey M. Manthorpe*
“Efficient, Scalable, and Economical Preparation of tris(Deuterium)- and 13C-Labelled N-Methyl-N-Nitroso-p-Toluenesulfonamide (Diazald®) and their Conversion to Labelled Diazomethane”
Journal of Labelled Compounds and Radiopharmaceuticals 2014, 57, 674-679. LINK

15. Noof A. Alenazi, Edward P. C. Lai, and Jeffrey M. Manthorpe*
“Enhanced Selectivity of a Molecularly Imprinted Polymer toward the Target Molecule via Esterification of Non-Specific Binding Sites with Diazomethane”
Journal of Molecular Recognition 2014, 27, 755-762. LINK

14. Karl V. Wasslen, Le Hoa Tan, Jeffrey M. Manthorpe*, and Jeffrey C. Smith*
“Trimethylation Enhancement using Diazomethane (TrEnDi): Rapid On-Column Quaternization of Peptide Amino Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge”
Analytical Chemistry 2014, 86, 3291-3299. LINK

13. Jeffrey M. Manthorpe*, Han Il Kong, John W. Palko, and Monica A. Gill
“Reduction of Sulfur–Carbon Bonds and of Other Heteroatoms Bonded to Tetrahedral Carbon”
Comprehensive Organic Synthesis, 2nd Edition; Molander, G. A., Knochel, P., Eds; Elsevier: Oxford, 2014; Vol. 8, pp 1031-1085. LINK

12. John W. Palko, Peter H. Buist, and Jeffrey M. Manthorpe*
“A Flexible and Modular Stereoselective Synthesis of (9R,10S)-Dihydrosterculic Acid”
Tetrahedron: Asymmetry 2013, 24, 165-168. LINK

11. Han Il Kong, Monica A. Gill, Amy H. Hrdina, Jennifer E. Crichton, and Jeffrey M. Manthorpe*
“Reactivity of α-Trifluoromethanesulfonyl Esters, Amides and Ketones: Decarboxylative Allylation, Methylation, and Enol Formation”
Journal of Fluorine Chemistry, 2013, 153, 151-168. LINK

10. Monica A. Gill and Jeffrey M. Manthorpe*
“Mild, Rapid, and Inexpensive Microwave-Assisted Synthesis of Allylic and Propargylic Esters”
Synthetic Communications 2013, 43, 1460-1468. LINK

9. Han Il Kong, Jennifer E. Crichton, and Jeffrey M. Manthorpe*
“Stereoselective Synthesis of Ambiphilic Alkenes via Regioselective Methylation of α-Trifluoromethansulfonyl Carbonyl Compounds with Trimethylsilyldiazomethane”
Tetrahedron Letters 2011, 52, 3714-3717. LINK

Publications from Postdoctoral, Graduate and Undergraduate Studies:

8. Alex M. Szpilman, Damiano M. Cereghetti, Jeffrey M. Manthorpe, Nicholas R. Wurtz, and Erick M. Carreira
“Synthesis and Biophysical Studies on 35-Deoxy Amphotericin B Methyl Ester”
Chemistry, A European Journal 2009, 15, 7117-7128. LINK

7. Alex M. Szpilman, Jeffrey M. Manthorpe, and Erick M. Carreira
“Synthesis and Biological Studies of 35-Deoxy Amphotericin B Methyl Ester”
Angewandte Chemie International Edition 2008, 474339-4342. LINK

6. Alex M. Szpilman, Damiano M. Cereghetti, Nicholas R. Wurtz, Jeffrey M. Manthorpe, and Erick M. Carreira
“Synthesis of 35-Deoxy Amphotericin B Methyl Ester: A Strategy for Molecular Editing”
Angewandte Chemie International Edition 2008, 47, 4335-4338. LINK

5. Azélie Arpin, Jeffrey M. Manthorpe, and James L. Gleason
“A Practical Chiral Bicyclic Thioglycolate Lactam Auxiliary for Stereoselective Quaternary Carbon Formation”
Organic Letters 2006, 8, 1359-1362. LINK

4. Jeffrey M. Manthorpe, Alex M. Szpilman, and Erick M. Carreira
“A Scalable Synthesis of a Mycosamine Donor. Overcoming Difficult Reactivity in Allose Systems”
Synthesis 2005, 3380-3388. LINK

3. Jeffrey M. Manthorpe and James L. Gleason
“Asymmetric Synthesis of Quaternary Carbon Centers. Alkylation of α,α-Disubstituted Enolates Generated by Reduction of Bicyclic Thioglycolate Lactams”
Angewandte Chemie International Edition 2002, 41, 2338-2341. LINK

2. Gordon L. Lange, Craig C. Humber, and Jeffrey M. Manthorpe
“[2+2] Photoadditions with Chiral 2,5-Cyclohexadienone Synthons”
Tetrahedron: Asymmetry 2002, 13, 1355-1362. LINK

1. Jeffrey M. Manthorpe and James L. Gleason
“Stereoselective Generation of E- and Z- Disubstituted Amide Enolates.  Reductive Enolate Formation from Bicyclic Thioglycolate Lactams”
Journal of the American Chemical Society 2001, 123, 2091-2092. LINK