If you are interested in working with me during your 4th-year project, please contact me at email@example.com. Please include the following information for all prospective group members:
- A resume or CV showing both academic and industry experience;
- An academic transcript (electronic);
- A brief statement of interest detailing which project(s) you are interested in working on, and what you hope to gain from this experience (e.g. research experience, collaboration with industry or other departments, developing a particular skill, etc.). Please keep it to a maximum of 1 page.
- What extracurricular activities are you involved with and why?
Do not forget to visit the SYSC4907/4917 course website for all information related to the course, including a list of currently available projects.
*If you have your own idea for a project and would like me to supervise you and your group, please send me an email to schedule a meeting to discuss it.
1 – Building a low-cost 3D-bioprinter [Tissue Engineering]
Description: Who would think that one day we would be printing biological tissues in the same way we transfer ink to paper? Although this sentence oversimplifies a complex process, 3D-bioprinting is one of the most promising technologies of the 21st century. 3D models and related organ-on-a-chip technologies represent powerful new tools in biomedical research, and 3D-bioprinting has been a major driver of innovation in medicine. In this project, students will face the challenge of building, testing and optimizing a low-cost 3D bioprinter. Creativity will be fundamental to achieving success.
To learn more about the topic I recommend you visit the following pages:
2 – Biomedical Imaging Visualization Toolbox [Image Processing / Software]
Description: The reconstruction of 3D structures is very important for different applications, including biomedical areas. Seeing the arrangement of cells and tissue fibres is crucial to understanding what is happening in diseases, how the body is responding to therapies, etc. In this project, students are expected to develop an automated toolbox for 3D reconstructions of microscopy* images. The toolbox is expected to have a user-friendly interface and allow the integration of image analysis modules to acquire information about the reconstructed shapes (e.g. fibers, cells). If interested, students can aim to develop a fully functional plugin for Fiji/ImageJ.
*some test images will be provided to the group.
3- Simulating organs and tissues: low-cost stretch chamber [Tissue Engineering]
Description: In tissue engineering, one of the biggest challenges is to be able to simulate the conditions cells find in our bodies. Biochemical and mechanical cues are important elements in organs and tissues, which cause the cells to behave in certain ways (e.g. heal injuries, migrate from one site to another, etc). For example, the lungs inflate and deflate as breathe. How can we simulate this movement, tissue stretching and contraction in the lab? In this project, students will develop a low-cost stretch chamber able to deform 3D bioprinted tissues and record biomechanical information from the sample (e.g. deformation coefficient) and allow the user to control parameters such as frequency of deformation and intensity. If the group manages to complete a functional prototype, I will provide you with real 3D bioprinted samples (containing cells!) to test your device. To see an example of this system, please watch this video. This project can also be adapted/integrated into the development of a system able to track the mechanical properties of the bioprinted samples. Here is one example of a commercial system.