Associate Professor, Graduate Advisor, Co-Director Tissue Engineering and Applied Materials (TEAM) Hub
|Phone:||613-520-2600 x 4462|
Primary field of Specialization:
Immunology, Infectious Disease and Immunometabolism
My research uses a combination of immunological and biochemical approaches, tissue engineering and optical imaging to identify novel regulators of macrophage responses to viruses and bacteria across diverse tissue microenvironments. Our aim is to better understand these interactions to develop new therapeutics that target macrophage function to fine tune inflammatory processes, clear infection and restore healing and tissue homeostasis (e.g., chronic wounds and solid tumours).
Current projects include:
PROJECT 1: Evaluating the role of mitochondrial reprogramming in antimicrobial immune responses.
PROJECT 2: Understanding how interactions between microbial communities and tissue macrophages contribute to delayed wound healing.
PROJECT 3: Targeting tumour associated macrophages with oncolytic viruses to restore anti-tumour immune responses.
PROJECT 4: Investigating how interactions between macrophages and fibroblasts in the lung contribute to the development of fibrosis and disease.
Label-free two-photon imaging of mitochondrial activity in murine macrophages stimulated with bacterial and viral ligands. Allen CH, Ahmed D, Raiche-Tanner O, Chauhan V, Mostaço-Guidolin L, Cassol E, Murugkar S. Sci Rep. 2021 Jul 7;11(1):14081. doi: 10.1038/s41598-021-93043-9.
Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation. Versey Z, da Cruz Nizer WS, Russell E, Zigic S, DeZeeuw KG, Marek JE, Overhage J, Cassol E. Front Immunol. 2021 Apr 9;12:648554. doi: 10.3389/fimmu.2021.648554. eCollection 2021.
HIF-1α Regulation of Cytokine Production following TLR3 Engagement in Murine Bone Marrow-Derived Macrophages Is Dependent on Viral Nucleic Acid Length and Glucose Availability. Ahmed D, Humphrey A, Roy D, Sheridan ME, Versey Z, Jaworski A, Edwards A, Donner J, Abizaid A, Willmore W, Kumar A, Golshani A, Cassol E.
Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages. Ahmed D, Roy D, Jaworski A, Edwards A, Abizaid A, Kumar A, Golshani A, Cassol E. Sci Rep. 2019 Dec 11;9(1):18801. doi: 10.1038/s41598-019-55295-4.