Publication:Life Science Weekly
Date:Tuesday April 23rd, 2013
Page:4168
Summary
This disorder involves multiple physiological defects that result from high blood glucose content and eventually lead to
the onset of insulin resistance.” The news reporters obtained a quote from the research from Carleton University, “The
combina…
Text
2013 APR 23 (NewsRx) — By a News Reporter-Staff News Editor at Life Science Weekly — Researchers detail new
data in Peptide Proteins. According to news reporting originating in Ottawa, Canada, by NewsRx journalists, research
stated, “An important disease among human metabolic disorders is type 2 diabetes mellitus. This disorder involves multiple
physiological defects that result from high blood glucose content and eventually lead to the onset of insulin resistance.”
The news reporters obtained a quote from the research from Carleton University, “The combination of insulin resistance,
increased glucose production, and decreased insulin secretion creates a diabetic metabolic environment that leads to a
lifetime of management. Appropriate models are critical for the success of research. As such, a unique model providing
insight into the mechanisms of reversible insulin resistance is mammalian hibernation. Hibernators, such as ground squirrels
and bats, are excellent examples of animals exhibiting reversible insulin resistance, for which a rapid increase in body
weight is required prior to entry into dormancy. Hibernator studies have shown differential regulation of specific molecular
pathways involved in reversible resistance to insulin. The present review focuses on this growing area of research and
the molecular mechanisms that regulate glucose homeostasis, and explores the roles of the Akt signaling pathway during
hibernation. Here, we propose a link between hibernation, a well-documented response to periods of environmental stress,
and reversible insulin resistance, potentially facilitated by key alterations in the Akt signaling network, PPAR-gamma/PGC-1
alpha regulation, and non-coding RNA expression. Coincidentally, many of the same pathways are frequently found to be
dysregulated during insulin resistance in human type 2 diabetes.”
According to the news reporters, the research concluded: “Hence, the molecular networks that may regulate reversible
insulin resistance in hibernating mammals represent a novel approach by providing insight into medical treatment of insulin
resistance in humans.”
For more information on this research see: Biochemical adaptations of mammalian hibernation: exploring squirrels as a
perspective model for naturally induced reversible insulin resistance. Brazilian Journal of Medical and Biological Research,
2013;46(1):1-13. Brazilian Journal of Medical and Biological Research can be contacted at: Assoc Bras Divulg Cientifica,
Faculdade Medicina, Sala 21, 14049 Ribeirao Preto, Sao Paulo, 00, Brazil.
Our news correspondents report that additional information may be obtained by contacting C.W. Wu, Carleton University,
Inst Biochem, Dept. of Biol, Ottawa, ON K1S 5B6, Canada.
Keywords for this news article include: Ottawa, Canada, Ontario, Chemistry, Proinsulin, Biochemical, Peptide Hormones,
Peptide Proteins, North and Central America
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