David Overy
Adjunct Research Professor
| Degrees: | B.Sc. (Carleton), Ph.D. (Technical University of Denmark) |
| Phone: | 613-759-1857 |
| Email: | david.overy@agr.gc.ca |
| Office: | 4017 A/B, Neatby Building, Ottawa Research and Development Centre (Central Experimental Farm), Ottawa |
Current Research
Dr. Overy is a Research Scientist at Agriculture and AgriFood Canada and runs a multi-disciplinary research program in metabolomics, natural products discovery and high-throughput culturing of fungi for biotechnological applications. His research interests include integrating mass spectrometry based metabolomics with current –omics methodologies in a variety of disciplines, including natural products discovery and metabolite phenotyping of fungi, modeling host/pathogen metabolite interaction during crop disease, and applying gene editing tools to link fungal plant pathogen secondary metabolism with corresponding biosynthetic gene clusters. Dr. Overy’s lab also actively isolates a variety of fungi from different environments and formally describes new species of fungi using polyphasic taxonomic approaches (traditional microscopy, phylogenetics, and secondary metabolite profiling). Dr. Overy holds an adjunct professor status with the Department of Biology at Carleton University and he teaches courses in Mass Spectrometry Based Metabolomics both nationally and internationally as directed studies courses (undergraduates) and graduate level classes.
Selected Publications
Mack JN, Sproule A, Shields SW, Seifert KA, Smith M, Overy DP. 2024. Two novel Pleosporales species isolated from the bark of Acer saccharum. Fungal Systematics and Evolution, 13, 1-14. https://doi.org/10.3114/fuse.2024.13.01
Hicks C, Witte TE, Sproule A, Hermans A, Shields SW, Colquhoun R, Blackman C, Boddy CN, Subramaniam R, Overy DP. 2023. CRISPR-Cas9 gene editing and secondary metabolite screening confirm Fusarium graminearum C16 biosynthetic gene cluster products as decalin-containing diterpenoid pyrones. Journal of Fungi, 9, 695. https://doi.org/10.3390/jof9070695
Witte TE, Villenueve N, Shields SW, Sproule A, Eggertson Q, Kim NE, Boddy CN, Dettman JR, Overy DP. 2022. Untargeted metabolomics screening reveals unique secondary metabolite production from Alternaria section Alternaria. Frontiers in Molecular Biosciences, 9:1038299. https://doi.org/10.3389/fmolb.2022.1038299
Hicks C, Witte TE, Sproule A, Lee T, Shoukouhi P, Popovic Z, Menzies JG, Boddy CN, Liu M, Overy DP. 2021. Evolution of the ergot alkaloid biosynthetic gene cluster results in divergent mycotoxins profiles in Claviceps purpurea sclerotia. Toxins, 13(12), 861; https://doi.org/10.3390/toxins13120861
Witte TE, Harris LJ, Nguyen HDT, Hermans A, Johnston A, Sproule A, Dettman JR, Boddy CN, Overy DP. 2021. Apicidin biosynthesis is linked to accessory chromosomes in Fusarium poae isolates. BMC Genomics, 22:591. https://doi.org/10.1186/s 12864-021-07617-y