Sue Twine
Adjunct Research Professor
| Degrees: | B.Sc. Biochemistry (University of Southampton, UK), Ph.D. Biochemistry (University of Southampton, UK), MBA (Heriot Watt University, UK) |
| Phone: | 613-668-5814 |
| Email: | susan.twine@nrc-cnrc.gc.ca |
| Office: | 100 Sussex Drive, room 2033 |
| LinkedIn: | Connect |
Current Research
Sue currently leads Mass Spectrometry and NMR research facilities within the National Research Council’s Human Health Therapeutics Research Centre, which broadly support the development of vaccines and protein based biologics. Her research focuses upon the application of mass spectrometry and allied approaches to improve understanding of the interaction of bacterial pathogens with human hosts. This includes deciphering bacterial post translational modifications and their role in host colonization (bacterial glycobiology), and the study of the host immune response to disease (immunoproteomics).
Sue is also involved in the development of student and postdoctoral training programs across the National Research Council. Prospective undergraduate and graduate students are welcome to contact Sue to learn more about opportunities within her research group.
Selected Publications
Complete publication list here: https://www.ncbi.nlm.nih.gov/pubmed/?term=twine_s
Fulton KM, Baltat I, Twine SM. Immunoproteomics Methods and Techniques. Methods Mol Biol. 2019;2024:25-58. doi: 10.1007/978-1-4939-9597-4_2. PubMed PMID:31364041.
Chen R, Fauteux F, Foote S, Stupak J, Tremblay TL, Gurnani K, Fulton KM, Weeratna RD, Twine SM, Li J. Chemical Derivatization Strategy for Extending the Identification of MHC Class I Immunopeptides. Anal Chem. 2018 Oct 2;90(19):11409-11416. doi: 10.1021/acs.analchem.8b02420. Epub 2018 Sep 19. PubMed PMID: 30192525.
Fulton KM, Li J, Tomas JM, Smith JC, Twine SM. Characterizing bacterial glycoproteins with LC-MS. Expert Rev Proteomics. 2018 Mar;15(3):203-216. doi:10.1080/14789450.2018.1435276. Epub 2018 Feb 9. Review. PubMed PMID: 29400572.
Fulton KM, Mendoza-Barberá E, Twine SM, Tomás JM, Merino S. Polar Glycosylated and Lateral Non-Glycosylated Flagella from Aeromonas hydrophila Strain AH-1 (Serotype O11). Int J Mol Sci. 2015 Nov 27;16(12):28255-69. doi:10.3390/ijms161226097. PubMed PMID: 26633358; PubMed Central PMCID: PMC4691044.
Ménard R, Schoenhofen IC, Tao L, Aubry A, Bouchard P, Reid CW, Lachance P, Twine SM, Fulton KM, Cui Q, Hogues H, Purisima EO, Sulea T, Logan SM. Small-molecule inhibitors of the pseudaminic acid biosynthetic pathway: targeting motility as a key bacterial virulence factor. Antimicrob Agents Chemother. 2014 Dec;58(12):7430-40. doi: 10.1128/AAC.03858-14. Epub 2014 Sep 29. PubMed PMID:25267679; PubMed Central PMCID: PMC4249573.
Lindgren M, Tancred L, Golovliov I, Conlan W, Twine SM, Sjöstedt A. Identification of mechanisms for attenuation of the FSC043 mutant of Francisella tularensis SCHU S4. Infect Immun. 2014 Sep;82(9):3622-35. doi:10.1128/IAI.01406-13. Epub 2014 Jun 16. PubMed PMID: 24935978; PubMed Central PMCID: PMC4187832.
Strong PC, Fulton KM, Aubry A, Foote S, Twine SM, Logan SM. Identification and characterization of glycoproteins on the spore surface of Clostridium difficile. J Bacteriol. 2014 Jul;196(14):2627-37. doi: 10.1128/JB.01469-14. Epub 2014 May 9. PubMed PMID: 24816601; PubMed Central PMCID: PMC4097583.
Wilhelms M, Fulton KM, Twine SM, Tomás JM, Merino S. Differential glycosylation of polar and lateral flagellins in Aeromonas hydrophila AH-3. J Biol Chem. 2012 Aug 10;287(33):27851-62. doi: 10.1074/jbc.M112.376525. Epub 2012 Jun 25. PubMed PMID: 22733809; PubMed Central PMCID: PMC3431630
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