Sabatino, David

Dr. Sabatino’s lab focuses on research that spans the areas of nucleic acid, peptide and protein chemical biology. Our research aims to develop synthetically modified biomolecules for applications related to human health, nanotechnology and the material sciences. Specific research applications include:

• RNA Biotechnology. The Sabatino lab has pioneered the design and development of a new class of synthetic branch and hyperbranch (dendrimer-type) RNA. These novel RNA structures template the assembly of discrete, higher-order RNA nanostructures for screening and silencing oncogene expression in cancer cell lines resulting in potent anti-cancer effects. The Sabatino lab continues to innovate novel nucleic acid (supra)molecular structures for enhancing their therapeutic applications.
• Peptide and Protein Chemical Biology. The application of cell-targeting and penetrating peptides in nucleic acid (and drug) delivery is an active area of research in the Sabatino group. These high-precision delivery systems aim to advance new drug delivery formulations into clinical practice. Moreover, the Sabatino lab also applies machine learning tools to design and develop novel peptide binding ligands of important immunological receptors for applications in cancer immunotherapy and vaccine development.

For more info visit, the Sabatino Lab