Throughout the fall and winter terms, the Department of Chemistry is pleased to host a series of lectures delivered by guest speakers/visiting professors. Unless otherwise noted, fall lectures will take place on a Friday from 10:00 to 11:30 A.M. in the Tory building, Room 447.
Fall Term 2019 Department Seminar Schedule
Date: Monday September 16, 2019
Presenter: Professor Erin R. Johnson, Dalhousie University.
Richcraft Atrium, 6 pm
Date: Friday, September 27, 2019
Presenter: Dr Wing Fung, Vice President, Ortec Inc.
Lecture Title: Industrial Chemistry-Polymers
Abstract: Due to their broad range of properties both synthetic and natural polymers play essential and ubiquitous roles in everyday life. Examples will be given how to synthesis and use of polyacrylate, polyester and polyurethane in surgical glove coating, laser toner, permanent press and conductive coating on electronic devices.
Host: Edward Lai
Date: Friday, October 4, 2019
Presenter: Professor Prabodhika Mallikaratchy, City University of New York-Lehman College
Lecture Title: Integrating ligand-receptor interactions and in vitro evolution for streamlined discovery of artificial nucleic acid ligands against T-Cell receptor-CD3 Complex in human T-cells
Abstract: Empirical evidence generated over five decades has demonstrated that cells undergo structural changes at the molecular level in response to environmental cues. As membrane
receptor proteins are most attuned to such cues, they remain the most attractive therapeutic targets. In order to discover specific DNA ligands against cell-surface receptors, our group recently introduced a unique variant of SELEX, termed Ligand-guided Selection (LIGS). LIGS exploits the inherent evolutionary step of competition between weak and strong binders in a SELEX library. The iterative process in conventional SELEX is designed to outcompete low-affinity binders through a competitive process whereby high affinity binders move on through the selection process. By introducing a naturally occurring stronger, highly specific binder, for example, an antibody (Ab) interacting with its cognate epitope, LIGS out-competes specific aptamers from a partially enriched SELEX pool against cells expressing the same epitope. Here, we show that LIGS can be expanded to evolve functional nucleic acid (NA) ligands against the multi-component cell-surface receptor Tcell receptor-CD3ε complex expressed by cultured and primary cells using two monoclonal Abs, OKT3 and UCHT1, as competing ligands. Using bioinformatics analysis of the sequences obtained from Illumina sequencing, multiple aptamer candidates were identified. Collectively this presentation will show that by exploiting the inherent competition between weak and strong binders in a combinatorial library with existing ligand receptor interactions, multiple NA ligands against a multi-component receptor protein can be identified without changing the cell-surface landscape.
Host: Maria DeRosa
Date: Friday, October 18, 2019
Presenter: Dr. Zuzana Gajdosechova, NRC
Lecture Title: Mercury –the global pollutant
Host: Amy Rand
October 21-25 Fall Break
Date: Friday, November 8, 2019
Presenter: Professor Christine Caputo, University of New Hampshire
Lecture Title: Molecules + Materials: New Approaches to Solar Fuels Synthesis
Host: Sean Barry
Date: Friday, November 15, 2019
Presenter: Professor Ann English, Concordia University
Lecture Title: How mass spectrometry empowers the study of metalloprotein redox reactions in the test tube and cell
Host: Jeff Smith
Date: Friday, November 22, 2019
Presenter: Professor Chibuike Udenigwe, University of Ottawa
Lecture Title: Emerging health and biomaterial applications of food proteins
Host: Tyler Avis
Date: Friday, November 29, 2019
Presenter: Professor Jeremy Wulff, University of Victoria
Lecture Title: A Universal Polymer Crosslinker: the Back Story
Host: Jeff Manthorpe
Keep checking back to this site as other lectures and presentations will continue to be added as the winter term unfolds.