10th Meeting of the Canadian Oxidative Stress Consortium
May 30th to June 1st, 2018
Katz Group Centre for Pharmacy and Health Research
University of Alberta
Edmonton, AB
Chair: Arno G. Siraki
Executive Organizing Committee (EOC): Diana Averill-Bates, William Willmore, Christopher Perry, Scott Ryan, Jim Uniacke, Richard Schulz
Local Organizing Committee (LOC): Dinesh Babu, Bev Berekoff, Ayman El-Kadi, Elaine Leslie, Andrew Morgan, Lynne-Marie Postovit, John Seubert
COSC Final Program 2018 As A PDF
The LOC and EOC for the COSC has put together an outstanding scientific program that brings together today’s leading Canadian researchers in the field of oxidative stress. The University of Alberta COSC 2018 Meeting has ten symposia, including seven Scientific Symposia and three Trainee Presentation Symposia organized from the submitted abstracts. Scientific Symposia are held at the Allard Family Lecture Theatre, Room 1080 Katz Group Centre for Pharmacy and Health Research. Registration, exhibits, poster sessions, lunch and coffee breaks will be at held at the Katz Atrium.
Final Program Information
Wednesday, May 30, 2018
All events held in Allard Family Lecture Theatre, Room 1080 Katz Group Centre for Pharmacy and Health Research
8:00 – 8:30 AM
Katz Atrium
Registration
8:40-9:00 AM
Opening Ceremonies and Welcome
Arno Siraki (COSC 2018 Meeting Chair), Neal Davies, Ali Declan
9:00-10:00 AM
Session I: Oxidative Stress and Cancer
Chairs: Diana Averill-Bates, Andrew Morgan
Gurmit Singh, McMaster University, Hamilton, Ontario
“Oxidative stress induced regulation of xCT via STAT3”
Volker Blank, McGill University, Montréal, Quebec
“Linking bZIP transcription factor function to stress signaling and cancer”
Bill Willmore, Carleton University, Ottawa, Ontario
“Nuclear factor (erythroid-derived 2)-like-1 (NFE2L1 or Nrf1): at the cross roads of stress responses”
10:00-10:15 AM
Coffee & Tea Break Refreshments will be served
10:15-11:15 PM
Session I: Oxidative Stress and Cancer (continued)
Chairs: Diana Averill-Bates, Andrew Morgan
Lynne-Marie Postovit, University of Alberta, Edmonton, Alberta
“Oxygen as a regulator of the epigenome”
Alain Nepveu, McGill University, Montréal, Quebec
“Reactive-oxygen species and repair of oxidative DNA damage in cancer cells”
Michael Weinfeld, University of Alberta/CCI, Edmonton, Alberta
“The role of polynucleotide kinase/phosphatase in the repair of oxidative DNA damage”
11:15-12:00 AM
Session II: Selected Trainee Presentations
Chair: David Josephy
Adrian Young, Memorial University, St. John’s, Newfoundland
“Partial loss of matrix thiol oxidoreductase glutaredoxin-2 (GRX2) protects against diet-induced obesity by altering the bioenergetics of muscle mitochondria”
Zaid Almaayah, University of Alberta, Edmonton, Alberta
“A novel doxorubicin-vitamin D conjugate suppresses the growth of MG63 cells through an oxidative stress-dependent mechanism”
Rowida Mohamed, Carleton University, Ottawa, Ontario
“The role of stressors on the regulation of Wnt expression by Porcupine and Wntless in human colorectal carcinoma cells”
Edouard Charlebois, McGill University, Montréal, Quebec
“Hepatocellular transferrin receptor 1 controls systemic iron homeostasis by limiting iron-dependent induction of hepcidin”
Ahmed Essa, University of Alberta, Edmonton, Alberta
“Preserving mitochondrial function and limiting NLRP3 inflammasome activation as novel cardioprotective effects of n3-PUFAs against ischemia-reperfusion injury”
12:00-2:00 PM
Lunch (Katz Atrium), Exhibits, Poster Session I
2:00-2:30 AM
Keynote Lecture 1:
Koichiro Tsuchiya, Department of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University, Japan
“Nitrite exerts its physiological effects through NO-dependent and -independent manner”
Chair: Arno Siraki
2:30-3:30 PM
Session III: Pulmonary and Cardiovascular Disease
Chairs: Alain Nevpeu, Lindsey Felix
Paige Lacy, University of Alberta, Edmonton, Alberta.
“Regulation of superoxide release from eosinophils”
Stan Kubow, McGill University, Montreal, Quebec
“Isoprostane isoforms and isofurans provide differential oxidative stress associations with cardiometabolic risk, environmental contaminant exposure and metabolic disruptions”
Ayman El-Kadi, University of Alberta, Edmonton, Alberta
“Redox mechanisms of cellular hypertrophy in cardiomyocytes”
3:30-3:40 PM
Break
3:40-4:20 PM
Session III: Pulmonary and Cardiovascular Disease (continued)
Chairs: Alain Nevpeu, Lindsey Felix
Po-Yin Cheung, University of Alberta, Edmonton, Alberta
“Oxidative stress in transition”
Jason Acker, University of Alberta, Edmonton, Alberta
“The role that hemoglobin oxidation plays in the storage injury of liquid stored and cryopreserved RBCs and the potential this has in affecting patient outcomes”
4:30-6:30 PM
Networking & Hospitality – Earl’s Kitchen + Bar (8629 112 St NW)
Thursday, May 31, 2018
All events held in Allard Family Lecture Theatre, Room 1080 Katz Group Centre for Pharmacy and Health Research
9:00-10:00 AM
Session IV: Aging and Mitochondria
Chairs: Lindsey Suh, Nathalie Grandvaux
Evangelos Michelakis, University of Alberta, Edmonton, Alberta
“Mitochondria as regulators of the epigenome under stress conditions”
Ryan Mailloux, Memorial University, St John’s, Newfoundland
“Defining the function of mitochondrial redox switches in the modulation of metabolism and ROS production”
John Seubert, University of Alberta, Edmonton, Alberta
“Novel epoxylipids and mitochondria in aged hearts”
10:00-10:15 AM
Break
10:15-11:05 PM
Keynote Lecture 2:
Dr. Marc Fariss, CSO ToxSynergy
“Protective role of mitochondrial vitamin E in toxic oxidative stress”
Chair:Arno Siraki
11:05-11:20 AM
Break
11:20-12:00 AM
Session IV: Aging and Mitochondria (continued)
Chairs: Lindsey Suh, Nathalie Grandvaux
Michel Lebel, Université Laval, Québec, Quebec
“The impact of vitamin C on a premature aging mouse model of Werner syndrome”
Daniel Figeys, University of Ottawa, Ottawa, Ontario
“The circadian clock and aging”
12:00-1:30 PM
Lunch (Katz Atrium), Exhibits, Poster Session II
1:30-2:20 PM
Keynote Lecture 3:
Dr. Christine Winterbourn: Centre for Free Radical Research, University of Otago, Christchurch, New Zealand
“Neutrophils, hypochlorous acid, and the battle against bacterial infection”
Chair:Arno Siraki
2:20-2:30 AM
Break
2:30-3:50 PM
Session V: Oxidative Stress and Toxicology dedicated to Peter J. O’Brien
Arno Siraki, University of Alberta, Edmonton, Alberta
“Peter J. O’Brien – impact and contribution to oxidative stress in toxicology”
David Josephy, University of Guelph, Guelph, Ontario.
“Aromatic amines, nitroaromatics, nitroanilines, and azo dyes: wandering through the science of toxicology: following Peter J. O’Brien”
Diana Averill-Bates, Université du Québec à Montréal, Montréal, Quebec
“Induction of peroxiredoxins by heat shock is mediated by reactive oxygen species”
Shirley X.Y. Wu, University of Toronto, Toronto, Ontario
“Turning bad oxidative stress to good one by free radical-manipulating nanotechnology for improving cancer therapies”
3:50-4:00 PM
Break
4:00-5:00 PM
Session VI: Selected Trainee Presentations
Chair: William Willmore
Andrew Morgan, University of Alberta, Edmonton, Alberta
“Phenol red in cell-culture media: it does more than indicate pH”
Nagakannan Pandian, University of Manitoba, Winnipeg, Manitoba
“A novel executioner role for cathepsin B in Ferroptotic cell death”
Navid Koleini, University of Manitoba, Winnipeg, Manitoba
“Non-mitogenic or mitogenic FGF2 protects cardiomyocytes from acute Doxorubicin-induced damage via protein kinase CK2 -independent or -dependent pathways, respectively”
Dinesh Babu, University of Alberta, Edmonton, Alberta
“Eosinophil peroxidase as an activator of isoniazid”
Jonathon Lee, University of Calgary, Calgary, Alberta
“Failures in fatty acid metabolism as an exponent of mitochondrial dysfunction in aging neurons”
Sherif Shoeib, University of Alberta, Edmonton, Alberta
“Resveratrol protects against angiotensin II-induced cellular hypertrophy through inhibition of CYP1B1/mid-chain hydroxyeicosatetraenoic acid mechanism”
7:00-11:00 PM
Banquet and Awards Coast Hotel
Friday, June 1, 2018
All events held in Allard Family Lecture Theatre, Room 1080 Katz Group Centre for Pharmacy and Health Research
9:00-10:00 AM
Session VII: Oxidative Stress in Neurology
Chairs: Eftekhar Eftekharpour, Dinesh Babu
Glen Baker, University of Alberta, Edmonton, Alberta.
“Effects of the MAO-inhibiting antidepressant and carbonyl scavenger phenelzine on oxidative stress”
Willem Wildering, University of Calgary, Calgary, Alberta.
“Lipid peroxidation/lipotoxicity as the ‘perfect storm’ of the neurobiology of aging”
Ed Krol, University of Saskatchewan, Saskatoon, Saskatchewan
“Nordihydroguaiaretic acid oxidation and its influence on misfolding of alpha-synuclein”
10:00-10:15 AM
Break
10:15-11:15 AM
Session VII: Oxidative Stress in Neurology (continued)
Chairs: Eftekhar Eftekharpour, Dinesh Babu
Eftekhar Eftekharpour, University of Manitoba, Winnipeg, Manitoba.
“The contribution of thioredoxin system to autophagy-apoptosis: interplay in oxidative stress in neural cells”
Nathalie Grandvaux, Université de Montréal, Montréal, Quebec.
“Regulation of the interferon-mediated antiviral defense by redox modifications of signaling proteins”
Thomas Simmen, University of Alberta, Edmonton, Alberta
“ER-mitochondria contacts adapt to metabolic changes in cancer and neurodegeneration”
11:15-11:25 AM
Break
11:25-12:05 PM
Session VIII: Oxidative Stress, Health and Disease
Chairs: Zaid Almaayah, Edouard Charlebois
Siegfried Hekimi, Department of Biology, McGill University, Montréal, Quebec
“Making ubiquinone bioavailable”
Elaine Leslie, University of Alberta, Edmonton, Alberta
“Human cellular export pathways for arsenic”
12:05-1:20 PM
Lunch, Exhibits, Poster Take Down, COSC Executive Meeting
1:20-2:20 PM
Session VIII: Oxidative Stress, Health and Disease (continued)
Chairs: Zaid Almaayah, Edouard Charlebois
Kostas Pantopoulos, McGill University, Montreal, Quebec
“Hepcidin-mediated hypoferremia in inflammation requires Bmp6/Hjv/Smad signaling and physiological hepatic iron content”
James Friel, University of Manitoba, Winnipeg, Manitoba
“Feeding practice influences gut microbiome composition in preterm infants and the association with oxidative stress: A prospective cohort study”
Dajana Vuckovic, Concordia University, Montréal, Quebec
“Improving accuracy of thiol measurements: Comparison of N-ethyl maleimide and N-(1-phenylethyl) maleimide derivatization in combination with liquid chromatography – mass spectrometry analysis”
2:20-2:30 AM
Break
2:30-3:30 PM
Session VIII: Oxidative Stress, Health and Disease (continued)
Chairs: Amir Tabatabaei, Sherif Shoeib
Thomas Back, University of Calgary, Calgary, Alberta
“Small-molecule organoselenium mimetics of the biological antioxidant glutathione peroxidase”
Stephane Bourque, University of Alberta, Edmonton, Alberta
“Fetal iron deficiency causes sex and organ-specific patterns of mitochondrial dysfunction and oxidative stress”
Ann English, Concordia University, Montréal, Quebec
“Direct monitoring of changes in heme loading of an antioxidant heme protein in live cells induced by hydrogen peroxide”
3:30-3:40 PM
Closing Remarks
Arno Siraki, COSC 2018 Meeting Chair