COSC 9th Meeting
June 1st -3rd, 2016
University of Guelph
Guelph, ON
COSC 2016 Poster
The LOC and Executive Committee for the COSC has put together an outstanding scientific program that brings together today’s leading Canadian researchers in the field of oxidative stress. The Guelph COSC 2016 Meeting has nine symposia. Included in the nine symposia are 2 Graduate Trainee Symposia/Competition organized from the submitted abstracts. Scientific Sessions are held at the Rozanski Building, Room 102. Registration, exhibits, poster sessions, lunch and coffee breaks will be at held at the Rozanski Concourse.
Meeting Program Speaker Abstracts
Poster Abstracts Poster Titles
Program Information
Wednesday, June 1, 2016
8:00 – 9:00 AM
Rozanksi Concourse
Registration – Coffee & tea will be served
8:50-9:00 AM
Opening Remarks
Jim Uniacke and Scott Ryan, COSC 2016 Meeting Co-Chairs
9:00-10:00 AM
Keynote Address
Sponsored by: CIHR – Institute of Genetics
Alicia Kowaltowski, University of Sao Paolo, Sao Paolo, Brazil
“Mitochondria, the Flexible”
10:00-10:30 AM
Coffee & Tea Break Refreshments will be served
10:30-12:30 PM
Symposium I: Metabolism
Chair: Chris Perry, York University, Toronto, ON
10:30 – 10:50 AM
Ryan Mailloux, Department of Biochemistry, Memorial University, St. John’s, NL
“Functions of redox buffering networks in controlling mitochondrial ROS production”
10:50-11:10 AM
Gilles Gouspillou,Départmentdes Sciences de l’Activité Physique, Université du Québec à Montréal, Montreal, QC
“Mechanismsandimplications of mitochondrial dysfunction in the skeletal muscle aging process”
11:10-11:30 AM
Dean Betts, Department of Physiology and Pharmacology, Western University, London, ON
“The roles of the stress adaptor protein p66Shc during early embryo development”
11:30-11:50 AM
Brennan Smith, Department of Medicine, McMaster University, Hamilton, ON
“Salicylate-based drugs: The mechanism of action revisited”
11:50 AM-12:10 PM
Daniel Lark, Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA
“Mechanisms linking mitochondrial hydrogen peroxide production to skeletal muscle insulin resistance in vivo”
12:10-12:30 PM
Nicholas Forsyth, Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, 
Staffordshire, United Kingdom
“Human mesenchymal stem cell isolation and culture; Are hypoxia mimetic agents’ suitable alternatives to engineered oxygen control measures?”
12:30-2:00 PM
Rozanksi Concourse
Lunch – Poster Session and Exhibits
2:00-3:20 PM
Symposium II: Graduate Student Symposium A
Chair: Ann English, Concordia University, Montreal, QC
2:00-2:20 PM
Plenary talk: Dr. Ann English, Department of Chemistry and Biochemistry, Concordia University, Montreal, QC
“Cytochrome C peroxidase (CCP1), a protein at the crossroads of the stress response and heme trafficking in yeast”
Student Talks
2:20-2:35 PM
Meghan Hughes, School of Kinesiology and Health Science, York University, Toronto, ON
“Early onset of muscle-specific alterations in mitochondrial bioenergetics in D2.B10DMDmdx/2J mouse model of Duchenne Muscular Dystrophy”
2:35-2:50 PM
Natalia Zamorano, Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC
“Epithelial DUOX2 regulates a specific subset of antiviral and proinflammatory cytokines during virus infection”
2:50-3:05 PM
Vanessa Lundsgaard-Nielsenz, Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON
“Reactive carbonyl species and the heat stress response during plant reproduction”
3:05-3:20 PM
Danielle Drake, Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON
“Reduced subcellular levels or breast cancer 1 protein (BRCA1) and increased DNA damage in embryonic tissue and fetal brain of untreated and ethanol-exposed BRCA1 knockout progeny”
3:20-3:50 PM
Coffee & Tea Break Refreshments will be served
3:50-5:50 PM
Symposium III: DNA Repair
Chair: Louise Winn, Queen’s University, Kingston, ON
3:50-4:10 PM
Brian Hasinoff, College of Pharmacy, University of Manitoba, Winnipeg, MB
“Finally, a non-cardiotoxic doxorubicin analog”
4:10-4:30 PM
Peter McPherson, Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON
“Oxoguanine glycosylase 1 (Ogg1) and methylmercury-induced DNA damage? Gimme a break!”
4:30-4:50 PM
Adeel Safdar, Department of Pediatrics and Medicine, McMaster University, Hamilton, ON
“Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice”
4:50-5:10 PM
Rebecca Laposa, Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON
“Neurotoxicity initiated by nucleotide excision repair DNA lesions is rescued by 2′-deoxynucleosides”
5:10-5:30 PM
Alain Nepveu, Department of Oncology, McGill University, Montreal, QC
“CUX1 functions as anaccessory factor in the repair of oxidative DNA damage”
5:30-5:50 PM
Jeanne Mulder, Department of Biomedical and Molecular Sciences, Queen’s Unviersity, Kingston, ON
“The effect of deletion of 8-oxoguanine glycosykase on aflatoxin B1 tumorigenicity in mice”
6:30-8:30 PM
Science Complex Atrium
Opening Reception
Come and joing us for good food, networking, and socializing!
Thursday, June 2, 2016
8:00 – 9:00 AM
Rozanksi Concourse
Registration – Coffee & tea will be served
9:00-10:00 AM
Keynote Address
Christine Foyer, University of Leeds, Leeds, UK
“Glutathione: From the chloroplast to the nucleus”
10:00-10:30 AM
Coffee & Tea Break Refreshments will be served
10:30-12:30 PM
Symposium IV:Plants
Chair: Gale Bozzo, University of Guelph, Guelph, ON
10:30 – 10:50 AM
Barry Shelp, Department of Plant Agriculture, University of Guelph, Guelph, ON
“Stress and gamma-aminobutyrate metabolism in plants: An update”
10:50-11:10 AM
Allison McDonald, Department of Biology, Wilfrid Laurier University, Waterloo, ON
“The control of reactive oxygen species generation by terminal oxidases”
11:10-11:30 AM
William Zerges, Department of Biology, Concordia University, Montreal, QC
“Localized control of oxidized RNA”
11:30-11:50 AM
Chris Todd, Department of Biology, University of Saskatchewan, Saskatoon, SK
“Uriede metabolism in Arabidopsis in response to abiotic stress”
11:50 AM-12:10 PM
Jacqueline Bede, Department of Plant Science, McGill University, Montreal, QC
“Plant cellular redox responses to caterpillar herbivory: A tale of two cities”
12:10-12:30 PM
Greg Vanlerberghe, Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON
“Alternative oxidase respiration preserves both mitochondrial and chloroplast function during drought stress”
12:30-2:00 PM
Lunch – Poster Session and Exhibits
1:30 -2:00 PM
Exhibitor Workshop
Michael Kovach, Horiba Canada, Inc.
The workshop will coer the principle of operation of the ratiometric technique and its various applications in biology. Topics include the required hardware and sofrware, data acquistion, and analyses and the key advantages of using a fast-scanning excitation monochromator. At the end of the workshop, attendees will have a good grasp of Ratiometric Ion Imaging and may perhaps find applications of the technique in their own work.
2:00-3:05 PM
Symposium V: Graduate Student Symposium B
Chair: Gale Bozzo, University of Guelph, Guelph, ON
2:00-2:20 PM
Plenary talk: Dr. Gale Bozzo, Department of Plant Agriculture, University of Guelph, Guelph, ON
“Is oxidative stress metabolism associated with physiological injuries in pome fruit?”
Student Talks
2:20-2:35 PM
Sébastien Dumont, Département des Sciences Biologiques
S-glutathionylation of two Cys residues in Arabidopsis thaliana cytosolic triosephosphate isomerase”
2:35-2:50 PM
Jonathon Lee, Department of Biological Sciences, University of Calgary, Calgary, AB
“Metabolic alterations in aging neurons: evidence linking plasma membrane lipid peroxidation and mitochondrial dysfunction”
2:50-3:05 PM
KrithikaMuthukumaran, Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON
“Amelioration of neurodegenerative disease related symptoms and pathology by Ubisol – Q10
3:05-3:35 PM
Coffee & Tea Break Refreshments will be served
3:35-5:15 PM
Symposium VI: Cancer
Sponsored by CIHR Institute of Cancer Reaserch
Chair: Gummit Singh, McMaster University, Hamilton, ON
3:35-3:55 PM
Gurmit Singh, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON
“The Oncodynamic Role of Oxidative Stress”
3:55-4:15 PM
Lynne-Marie Postovit, Department of Oncology, University of Alberta, Edmonton, AB
“Oxygen as a regulator of tumor cell plasticity”
4:15-4:35 PM
Lina Dagnino, Department of Physiology and Pharmacology, Western University, London, ON
“Modulation of reactive oxygen species production by integrin-like kinase”
4:35-4:55 PM
Paul Spagnuolo, School of Pharmacy, University of Waterloo, Kitchener, ON
“Inhibition of fatty acid oxidation selectively eliminates acute myeloid leukemia cells and leukemia stem cells through ROS-mediated apoptosis”
4:55-5:15 PM
Diana Averill-Bates, Département des Sciences Biologiques, Université du Québec à Montréal, Montréal, QC
“Inhibition of autophagy sensitizes cells to hydrogen peroxide-induced apoptosis: Protective effect of thermotolerance acquired at 40 oC”
6:00 PM – 12:00 AM
Creelman Hall
6:00 – 7:00 PM
Reception & Jazz Band
Hors d’oeuvres will be served
7:00 PM – 12:00 AM
Banquet & Awards Presentations
Dinner will be served at 7:00 PM
Bring your dancing shoes to dance the night away!
Friday, June 3, 2016
8:00 – 9:00 AM
Rozanksi Concourse
Information Desk – Coffee & tea will be served
9:00-10:20 AM
Symposium VII: Neuroscience
Chair: Robert Cumming, Western University, London, ON
9:00 – 9:20 AM
Robert Cumming, Department of Biology, Western University, London, ON
“Aerobic glycolysis: food for thought or Achilles heel for Alzheimer’s disease”
9:20-9:40 AM
Leslie Buck, Department of Cell and Systems Biology, University of Toronto, Toronto, ON
“Scavenging reactive oxygen species initiates GABAA receptor-mediated electrical suppression in anoxia-tolerant turtle neurons”
9:40-10:00 AM
Willem Wildering, Department of Biological Sciences, University of Calgary, Calgary, AB
“Lipid per oxidation, free fatty acids and neuronal aging”
10:00-10:20 AM
Peter Wells, Faculty of Pharmacy, University of Toronto, Toronto, ON
“Oxidative DNA damage and repair in embryopathies and neurodevelopmental deficits”
10:20-10:50 AM
Coffee & Tea Break Refreshments will be served
10:50-12:10 PM
Symposium VIII: Diabetes and Kidney disease
Chair: Chris Kennedy, University of Ottawa, Ottawa, ON
10:50-11:10 AM
Chris Kennedy, Department of Medicine, Ottawa Hospital Research Institute, Ottawa, ON
“The role of Nox family members in diabetic kidney disease”
11:10-11:30 AM
Gabriel Gyulay, Department of Medicine and Nephrology, McMaster University, Hamilton, ON
“Absence of TDAG51 confers protection against vascular calcification”
11:30-11:50 AM
Melanie Wills, Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON
“The ShcD Protein Sensitizes the Epidermal Growth Factor Receptor (EGFR) to Oxidative Stress”
11:50 AM-12:10 PM
Chet Holterman, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, ON
“Toll-like receptors and NADPH Oxidase 5 activity; Oxidative stress takes a toll on renal function”
12:50-1:10 PM
Lunch
1:10-2:30 PM
Symposium IX: Transcriptional Control and Immunology
Chair: Natalie Grandvaux, Université de Montreal, Montreal, QC
1:10-1:30 PM
Volker Blank, Department of Medicine, Lady Davis Institute, McGill University, Montreal, QC
“Regulation of NFE2L3 (NRF3) transcription factor degradation by FBW7 and GSK3”
1:30-1:50 PM
William Willmore, Department of Biochemistry, Carleton University, Ottawa, ON
“NRF1: The lesser-known player in the antioxidant response”
1:50-2:10 PM
Jean-Claude Lavoie, CHU Sainte-Justine, Nutrition, Université de Montréal, Montréal, QC
“Is DNA methylation dependent on the redox potential value of glutathione?”
2:10-2:30 PM
Arno Siraki, Department of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB
“Anti-MPO produced from MPO-based protein free radicals. Implications for drug-induced agraulocytosis& lupus”
2:30 PM
Closing Remarks