Chet Holterman
Postdoctoral Fellow
| Phone: | 613-562-5800 x 8236 |
| Email: | cholterm@uottawa.ca |
| Office: | University of Ottawa Ottawa Hospital Research Institute |
| Website: | Browse |
Research: Dr. Holterman investigates the role of NADPH oxidase 5 (Nox5) in diabetic nephropathy. He focuses on identifying factors that directly initiate Nox5 activity and the downstream effects of this activity on podocyte injury. His research includes clinical aims such as therapies designed to inhibit Nox5 activity in nephropathy and reduce or inhibit the factors activating Nox5 expression. Interestingly it has been shown that Reactive Oxygen Species (ROS) generated by NADPH oxidase stabilize the hypoxia inducible factor (HIF) family of transcription factors and that HIF2a regulates protein translation in response to low oxygen in cancer cells. Dr. Holterman determines if ROS stabilization of HIF2a occurs in response to Nox5 and other Nox family member activity and whether this is sufficient to alter protein translation in response to diabetic stimuli.