Leila Mostaço-Guidolin

Associate Professor

• PhD in Biomedical Engineering (University of Manitoba), MSc (University of São Paulo, Brazil), BSc (University of São Paulo, Brazil )
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Primary Field of Specialization

Biomedical Imaging, Biomaterials, and Tissue Engineering

Research Interests

My research focuses on understanding how biological tissues remodel in health, aging, and disease. By combining advanced optical imaging, image analysis, and biomaterials engineering, my team investigates how the extracellular matrix (ECM), the structural scaffold surrounding cells, changes during chronic diseases such as asthma, fibrosis, cancer, and cardiovascular disease. We develop and apply label-free imaging techniques, including multiphoton microscopy, second harmonic generation (SHG), and Raman microspectroscopy, to quantify tissue architecture and uncover structure-function relationships that may serve as new biomarkers or therapeutic targets.

Selected Publications

1. Mostaço-Guidolin LB, et al. Collagen morphology and texture analysis: from statistics to classification. Scientific Reports. 2013;3:2190.
2. Mostaço-Guidolin LB, Osei ET, Ullah J, et al. Defective fibrillar collagen organization by fibroblasts contributes to airway remodeling in asthma. American Journal of Respiratory and Critical Care Medicine. 2019;200(4):431–443.
3. Osei ET, Mostaço-Guidolin LB, et al. Epithelial–fibroblast communication and extracellular matrix remodeling in chronic airway disease. Frontiers in Physiology. 2020.

Up to date list can be found here: https://scholar.google.com/citations?user=3y7q_scAAAAJ&hl=en&authuser=1