|Degrees:||Ph.D. (Leicester, UK)|
|Phone:||613 520-2600 x 8774|
|Office:||5303 Health Sciences Building|
Areas of Specialization / Field Affiliations
- Depression, genetics and genomics.
Eligible to supervise at the undergraduate and graduate level.
John Stead’s previous research covers various areas of genetics and genomics, including genetic analysis of susceptibility to diabetes, genetic and genomic studies of depression in humans, and studying animal models of stress-related disease.
Current projects include:
Genetic analysis of susceptibility to depression and problem gambling
Complex diseases such as depression and pathological gambling are due to the interaction of multiple genetic and environmental factors, each of which contributes a relatively small amount to the overall susceptibility to disease. I am interested in analyzing genetic variation in human disease-associated populations, to identify associations of specific genetic variants with disease. Specifically, we are investigating the genetic basis of personality variables that contribute to susceptibility to both major depression and problem gambling.
Genetic analysis of personality traits that influence individual creativity
Some people are more creative than others, and this is probably due to a combination of that individual’s environment and education, as well as contributions from their genes. We are currently exploring personality traits that associate with differences in individual creativity, and identifying genetic polymorphisms that may underlie those differences.
Using genomics tools to identify neural circuits dysregulated in animal models of anorexia nervosa
Anorexia nervosa is a severe, chronic eating disorder characterized by food restriction, excessive exercise and rapid weight loss. We are using animal models to simulate mild symptoms that are common with humans suffering from this disease, in order to understand the neural circuitry that contributes to disease, and explore potential treatments that can reduce the negative symptoms associated with anorexia.
Click here to access publications.