Professor and Department Head
|Phone:||(519) 253-4232 x 3526 or 3594|
|Office:||Department of Chemistry and Biochemistry|
University of Windsor
Research: The Mutus lab investigates 1) the development of analytical methods to measure levels of NO(NOx) and H2S; 2) discovering specific amino acids within the proteins that are susceptible to S-nitrosylation and S-sulfhydration; and 3) the identification of specific S-nitrosylated- and S-sufhydrated-proteins that are pivotal control points in a given pathology. An example protein is the cell membrane-resident enzyme neutral sphingomyelinase (NSMase). When normal cells are exposed to stress (such as chemotherapeutic drugs), NSMase is stabilized and activated making more of a compound (creamide) causes the cells to self destruct (apoptosis). The Mutus lab has recently discovered that cancer cells, when stressed, inactivate NSMase by S-nitrosylating it thereby avoiding the self destruct signal and surviving the stress. Currently, his lab is utilizing analytical/proteomic approaches to identify NSMase’s -S-N=O-susceptible regions with a view of preventing the inactivation of NSMase in cancer cells, thereby rendering them more susceptible to killing by chemotherapeutics.