|Degrees:||Ph.D. (University of Buenos Aires, Argentinia), M.Sc. (University of Buenos Aires, Argentinia)|
|Phone:||1-514-384-1934 x 35410|
|Office:||Medicine/Surgery (Urology Division)|
Research: Dr. O’Flaherty’s research program focuses on male reproduction, particularly on the molecular mechanisms involved in the production and function of healthy spermatozoa and the role of reactive oxygen species (ROS) in sperm physiology and toxicology. Through mouse models and human spermatozoa, Dr. O’Flaherty aims to elucidate the role of the reactive oxygen species and antioxidant enzymes in regulating sperm function using genomic, proteomic and biochemical approaches. Dr. O’Flaherty was the first to identify the primary role of peroxiredoxin 6 in protecting the spermatozoa against oxidative stress and the participation of peroxiredoxins in regulating ROS during sperm capacitation. He is also dedicated to deciphering the molecular mechanisms that drive the spermatozoon to achieve fertilizing ability. Moreover, Dr. O’Flaherty’s laboratory is deciphering the molecular mechanisms regulating sperm activation and developing novel diagnostic and therapeutic strategies for infertile men.