|Office:||Department of Medical Genetics|
University of British Columbia
Dr. Taubert’s lab is interested in the regulation of stress responses, including oxidative stress and conditions that induce oxidative stress. In particular, we study how transcriptional regulators adapt genome transcription in response to various types of stress. These metabolic and stress response pathways are of great biomedical relevance. For example, transcriptional activation of stress response programs helps cancers to grow in hostile microenvironments featuring oxidative stress, starvation, and hypoxia; vice versa, these pathways represent promising pharmacological targets to attack the cancer. We use the nematode worm C. elegans, the mouse, and cell culture models, including models of human disease (diabetes, neurodegenerative disorders).