Dr. Martin Holcik

• In-person event
• 4440Q, Carleton Technology and Training Centre, Carleton University
• 1125 Colonel By Drive, Ottawa, ON, K1S 5B6

• Contact
• Ashkan Golshani, ashkan.golshani@carleton.ca

Selective translation: tipping the scales of cancer

Dr. Martin Holcik, Apoptosis Research Center and the Molecular Biomedicine Program of the Children’s Hospital of Eastern Ontario Research Institute, and Department of Pediatrics at the University of Ottawa

Friday, February 14^th – 3:30PM – CTTC 4440Q

Faculty Host: Ashkan Golshani

Cancer • Apoptosis • Regulation of Protein Synthesis

Dr. Holcik is interested in the investigation of the regulation of protein synthesis, with specific emphasis on selective mRNA translation during pathophysiological cellular states such as cellular stress, apoptosis and cancer. Regulation of gene expression occurs at multiple levels, including translation. Control at the level of protein synthesis (and/or translation-coupled mRNA stability) allows cells to respond rapidly to changes in physiological conditions. Indeed, the repression or activation of translation occurs almost instantaneously, unlike regulation at other levels (such as transcription, mRNA processing, or protein modification and turnover) which entail a considerable time lag, and is therefore uniquely suited to provide the cell with plasticity to respond to adverse conditions.