Photo of Alex Wong

Alex Wong

Associate Professor

Degrees:B.A., M.A. (Carleton), Ph.D. (Cornell)
Phone:613-520-2600 x 3002
Email:alex_wong@carleton.ca
Office:245 Nesbitt Building
Website:Visit my lab website

Research

My research focuses on the genetics of adaptation. I am particularly interested in investigating the consequences of genetic interactions (epistasis) for rates and patterns of molecular evolution, and in understanding the potentially non-adaptive consequences of natural selection. The lab uses a variety of approaches to address these questions, including microbial experimental evolution, next-generation sequencing, and inference of historical evolutionary processes from comparative genomic and molecular population genetic data.

I am currently seeking students at all levels (undergraduate, Honour’s, Msc, and PhD) to join the lab. Projects may include lab-based studies of genetic interactions during pathogen adaptation, as well as computational.

Selected Publications

Wong A. 2017. Epistatic interactions of antimicrobial resistance mutations. Frontiers in Microbiology 8: 246.

Schoenrock A, Burnside D, Moteshareie H, Pitre S, Green JR, Golshani A, Dehne F, Wong A. 2017. Evolution of protein-protein interaction networks in yeast. PLoS One 12: e0171920.

McMahon T, Blais B, Wong A, Carrillo C. 2017. Multiplexed Single Intact Cell Droplet Digital PCR (MuSIC ddPCR) Method for Specific detection of enterohemorrhagic E. coli (EHEC) in food enrichment cultures. Frontiers in Microbiology 8:332.

 Huus KE, Joseph J, Zhang L, Wong A, Aaron SD, Mah T-F, Sad S. 2016. Clinical isolates of Pseudomonas aeruginosa from chronically infected cystic fibrosis patients fail to activate the inflammasome during both stable infection and pulmonary exacerbation. J Immunol 196: 3097-108.

Kapopolou A, Mathew L, Wong A, Trono D, Jensen JD. 2016. The evolution of gene expression and binding specificity of the largest transcription factor family in primates. Evolution 70: 167-80.

Wong A and Seguin K. 2015. Effects of genotype on rates of substitution during experimental evolution. Evolution 69: 1772-85.

Melnyk A, Wong A, Kassen R. 2015. The fitness costs of antibiotic resistance mutations. Evolutionary Applications 8: 273-283.

Wong A. 2014. Covariance between testes size and substitution rates in primates. Molecular Biology and Evolution 31: 1432-1436.

Bank C, Hietpas RT, Wong A, Bolon DN, Jensen JD. 2014. A Bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments. Genetics 196: 841-852.

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